{"id":"synera-tm","safety":{"commonSideEffects":[{"rate":null,"effect":"Erythema at application site"},{"rate":null,"effect":"Edema at application site"},{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Blanching"}]},"_chembl":{"chemblId":"CHEMBL3940508","moleculeType":"Small molecule","molecularWeight":"567.84"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Synera uses heat-activated technology to enhance the penetration of lidocaine and tetracaine through the skin. The patch generates heat when activated, which increases blood flow and drug permeability, allowing the local anesthetics to reach deeper tissue layers and provide faster onset of anesthesia compared to non-heated patches.","oneSentence":"Synera is a topical anesthetic patch that combines lidocaine and tetracaine to provide rapid local anesthesia through transdermal delivery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:10:28.338Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia for superficial venous access and dermatological procedures"}]},"trialDetails":[{"nctId":"NCT00564785","phase":"PHASE4","title":"Synera™ for Epidural Needle Insertion","status":"COMPLETED","sponsor":"IWK Health Centre","startDate":"2007-02","conditions":"Pain Associated With Epidural Needle Insertion","enrollment":33}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":40,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Synera(TM)","genericName":"Synera(TM)","companyName":"IWK Health Centre","companyId":"iwk-health-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Synera is a topical anesthetic patch that combines lidocaine and tetracaine to provide rapid local anesthesia through transdermal delivery. Used for Topical anesthesia for superficial venous access and dermatological procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}