{"id":"synera-patch-for-12hrs-day","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or erythema at application site"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Temporary blanching or edema"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The patch combines two local anesthetics—lidocaine and tetracaine—that penetrate the skin and reversibly inhibit sodium influx in nerve cell membranes, preventing depolarization and blocking pain signal transmission. The 12-hour daily application provides localized numbing suitable for minor procedures or pain relief without systemic absorption.","oneSentence":"Synera patch delivers lidocaine and tetracaine through the skin to provide topical anesthesia by blocking sodium channels in nerve fibers.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:38:21.692Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia for minor procedures (e.g., venipuncture, dermatological procedures)"},{"name":"Localized pain relief"}]},"trialDetails":[{"nctId":"NCT01525043","phase":"PHASE4","title":"Study to Evaluate the Efficacy of the Synera Patch Compared to Naproxen Sodium for Epicondylitis of the Elbow","status":"COMPLETED","sponsor":"International Clinical Research Institute","startDate":"2012-02","conditions":"Epicondylitis of the Elbow","enrollment":78}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Synera patch for 12hrs/day","genericName":"Synera patch for 12hrs/day","companyName":"International Clinical Research Institute","companyId":"international-clinical-research-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"The Synera patch is a small molecule used to treat epicondylitis of the elbow. It is applied for 12 hours a day, with its efficacy compared to naproxen sodium in clinical trials.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}