{"id":"symptomatic-drugs","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL1863515","moleculeType":"Enzyme"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Symptomatic treatment addresses the clinical manifestations and discomfort associated with a disease or condition, improving patient quality of life and functional status. These drugs do not modify disease progression or cure the underlying condition, but rather manage specific symptoms such as pain, tremor, spasticity, or other neurological manifestations. This approach is commonly used in neurology when disease-modifying therapies are unavailable or as adjunctive treatment.","oneSentence":"Symptomatic drugs provide relief from disease symptoms without targeting the underlying pathological mechanism.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:10:26.489Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Symptomatic management of neurological disorders"}]},"trialDetails":[{"nctId":"NCT07113691","phase":"PHASE1","title":"Iadademstat + SBRT With Atezo in ES-SCLC","status":"RECRUITING","sponsor":"Yale University","startDate":"2026-01-20","conditions":"Extensive Stage Small Cell Lung Cancer (ES-SCLC)","enrollment":15},{"nctId":"NCT06560476","phase":"","title":"OPtilume™ BPH Catheter SystEm for Treatment of Men eXperiencing Symptomatic BPH","status":"RECRUITING","sponsor":"Urotronic Inc.","startDate":"2024-03-30","conditions":"Benign Prostatic Hyperplasia","enrollment":500},{"nctId":"NCT06679140","phase":"PHASE3","title":"A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease","status":"RECRUITING","sponsor":"Pfizer","startDate":"2024-12-08","conditions":"COVID-19 SARS-CoV-2 Infection","enrollment":2330},{"nctId":"NCT07174947","phase":"PHASE2","title":"SSRI Antidepressant Fluoxetine Improving Immunotherapy Efficacy in Advanced Hepatobiliary Malignancy Patients With Depression and Anxiety","status":"RECRUITING","sponsor":"First Affiliated Hospital of Wenzhou Medical University","startDate":"2025-10-01","conditions":"Hepatobiliary Malignancy, Fluoxetine, Anxiety Disorders","enrollment":240},{"nctId":"NCT07491601","phase":"NA","title":"PRESS -PAR: Early Detection and PREvention of Symptomatic postSurgical hypoPARathyroidism After Thyroid Surgery\"","status":"RECRUITING","sponsor":"Nicolas Schlegel","startDate":"2025-01-08","conditions":"Postoperative Hypoparathyroidism, Postsurgical Hypoparathyroidism, Hypoparathyroidism Post-surgical","enrollment":336},{"nctId":"NCT07491107","phase":"","title":"Brazilian Prospective Registry of the Inspiron EVO Drug-Eluting Stent in Complex Coronary Lesions","status":"NOT_YET_RECRUITING","sponsor":"Scitech Produtos Medicos SA","startDate":"2026-04-30","conditions":"Coronary Artery Disease (CAD), Stenosis Coronary, Small Vessel Ischemic Disease","enrollment":2000},{"nctId":"NCT04818645","phase":"NA","title":"Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Rochester","startDate":"2023-01-31","conditions":"Atrial Fibrillation, Heart Failure","enrollment":477},{"nctId":"NCT04668170","phase":"","title":"Predictive Immune Biomarkers of COVID-19 Pathogenesis to Influence Therapeutic Management","status":"COMPLETED","sponsor":"University Hospital, Toulouse","startDate":"2020-05-05","conditions":"COVID-19","enrollment":304},{"nctId":"NCT07023341","phase":"PHASE3","title":"A Study to Learn More About How Well Aficamten Works in Japanese Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Bayer","startDate":"2025-06-30","conditions":"Obstructive Hypertrophic Cardiomyopathy","enrollment":36},{"nctId":"NCT06451120","phase":"PHASE2","title":"Platelet Rich Plasma Injections In Young And Old Human Subjects","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2024-06-01","conditions":"Osteoarthritis, Articular Cartilage, Musculoskeletal Disorders","enrollment":60},{"nctId":"NCT07310927","phase":"PHASE2, PHASE3","title":"Alginate vs Sucralfate for GERD Symptomatic Relief","status":"RECRUITING","sponsor":"CMH Lahore Medical College and Institute of Dentistry","startDate":"2025-04-01","conditions":"GERD","enrollment":140},{"nctId":"NCT06471257","phase":"PHASE3","title":"A Study to Investigate Efficacy and Safety of PT027 Compared With PT007 in Symptomatic Chinese Adults With Asthma","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2024-06-17","conditions":"Asthma","enrollment":790},{"nctId":"NCT07092514","phase":"PHASE2","title":"Lenvatinib 24 mg/Day Versus 10 mg/Day to Treat Symptomatic or Progressive Radioactive Iodine Resistant (RAIR) Differentiated Thyroid Cancer (DTC)","status":"RECRUITING","sponsor":"Washington University School of Medicine","startDate":"2025-10-14","conditions":"Thyroid Cancer, Cancer of the Thyroid","enrollment":34},{"nctId":"NCT07475663","phase":"PHASE3","title":"Counterpain PXM Versus Diclofenac Versus Piroxicam","status":"COMPLETED","sponsor":"Taisho Pharmaceutical Indonesia","startDate":"2025-11-04","conditions":"Ankle Sprain, Back Pain, Osteoarthritis (OA) of the Knee","enrollment":180},{"nctId":"NCT04838769","phase":"NA","title":"REZŪM vs. Dual Drug Therapy for Symptomatic Benign Prostatic Hyperplasia in Sexually Active Men","status":"ACTIVE_NOT_RECRUITING","sponsor":"Boston Scientific Corporation","startDate":"2021-09-15","conditions":"Benign Prostatic Hyperplasia (BPH)","enrollment":154},{"nctId":"NCT06621524","phase":"","title":"EucaLimus Post-Market Registry","status":"ACTIVE_NOT_RECRUITING","sponsor":"OrbusNeich","startDate":"2025-03-14","conditions":"Coronary Arterioscleroses","enrollment":251},{"nctId":"NCT06832631","phase":"","title":"VITUS Post-Market Registry","status":"RECRUITING","sponsor":"OrbusNeich","startDate":"2025-05-22","conditions":"Peripheral Arterial Disease, Peripheral Arterial Occlusive Disease","enrollment":284},{"nctId":"NCT07381634","phase":"PHASE2","title":"The Safety and Efficacy of Ondansetron in Reducing Immune Checkpoint Inhibitor-Related Toxicities","status":"NOT_YET_RECRUITING","sponsor":"First Affiliated Hospital of Wenzhou Medical University","startDate":"2026-03-20","conditions":"Hepatocellular Carcinoma (HCC), IrAE","enrollment":134},{"nctId":"NCT06769217","phase":"PHASE4","title":"Clinical Investigation for Everolimus Drug Eluting Stent","status":"COMPLETED","sponsor":"Frisch Medical Device Private Limited","startDate":"2023-01-01","conditions":"Coronary Arterial Disease (CAD)","enrollment":888},{"nctId":"NCT07461558","phase":"NA","title":"Watchful Waiting Versus Immediate Repair for Occult Contralateral Inguinal Hernias.","status":"RECRUITING","sponsor":"Northwestern University","startDate":"2026-04","conditions":"Inguinal Hernia Bilateral, Inguinal Hernia Unilateral","enrollment":380},{"nctId":"NCT06671938","phase":"PHASE2","title":"Safety, Tolerability, and Pharmacokinetics of Exidavnemab in Patients With Parkinson's Disease and Patients With Multiple System Atrophy","status":"ACTIVE_NOT_RECRUITING","sponsor":"BioArctic AB","startDate":"2024-10-24","conditions":"Parkinson Disease, Multiple System Atrophy","enrollment":38},{"nctId":"NCT07444580","phase":"PHASE1","title":"PrP-targeting siRNA Safety & Mechanism Study","status":"NOT_YET_RECRUITING","sponsor":"Broad Institute of MIT and Harvard","startDate":"2026-04","conditions":"Prion Disease","enrollment":30},{"nctId":"NCT05254314","phase":"PHASE2","title":"Glucagon-Like Peptide-1 Receptor Agonist in the Treatment of Adult, Obesity-related, Symptomatic Asthma (GATA-3)","status":"RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2022-10-11","conditions":"Asthma","enrollment":100},{"nctId":"NCT05946993","phase":"NA","title":"Linking In With Advice and Supports for Men Impacted by Metastatic Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"University College Cork","startDate":"2023-05-08","conditions":"Survivorship, Prostate Cancer, Kidney Cancer","enrollment":72},{"nctId":"NCT07013474","phase":"PHASE3","title":"A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised","status":"RECRUITING","sponsor":"Pfizer","startDate":"2025-07-14","conditions":"COVID-19 Infection","enrollment":300},{"nctId":"NCT07181590","phase":"NA","title":"BaLloon-based PFA Ablation poST Approval Outcomes for PAF and PersAF","status":"RECRUITING","sponsor":"Abbott Medical Devices","startDate":"2025-12-11","conditions":"Paroxysmal AF, Atrial Arrhythmia, Atrial Fibrillation","enrollment":300},{"nctId":"NCT06634654","phase":"NA","title":"An Artificial Intelligence-based Approach in Total Knee Arthroplasty: From Inflammatory Responses to Personalized Medicine","status":"RECRUITING","sponsor":"Fondazione Policlinico Universitario Campus Bio-Medico","startDate":"2024-10-14","conditions":"Knee Osteoarthritis","enrollment":197},{"nctId":"NCT07423390","phase":"PHASE3","title":"Study on the Efficacy and Safety of Mecobalamin in Preventing Taxane-related Peripheral Neuropathy","status":"RECRUITING","sponsor":"Qinghai Red Cross Hospital","startDate":"2026-02-24","conditions":"Peripheral Neuropathy Due to Chemotherapy, Peripheral Neuropathy, Chemotherapy-induced","enrollment":326},{"nctId":"NCT06735534","phase":"NA","title":"Repeat Ablation of Persistent Atrial Fibrillation, Including Mitral Isthmus Catheter Ablation, With the FARAPULSE Pulsed Field Ablation System","status":"RECRUITING","sponsor":"Boston Scientific Corporation","startDate":"2025-06-03","conditions":"Persistent Atrial Fibrillation","enrollment":407},{"nctId":"NCT06170606","phase":"NA","title":"POLARx Post Approval Study (POLARx PAS)","status":"RECRUITING","sponsor":"Boston Scientific Corporation","startDate":"2024-06-28","conditions":"Paroxysmal Atrial Fibrillation","enrollment":200},{"nctId":"NCT05109364","phase":"PHASE2","title":"Terazosin and Parkinson's Disease Extension Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cedars-Sinai Medical Center","startDate":"2022-09-23","conditions":"Symptomatic Parkinson Disease, REM Sleep Behavior Disorder, Pre-motor Parkinson's Disease","enrollment":15},{"nctId":"NCT05291247","phase":"","title":"Shockwave IVL + DES","status":"COMPLETED","sponsor":"Marc Bosiers, MD","startDate":"2022-07-22","conditions":"Peripheral Arterial Disease, Superficial Femoral Artery Stenosis, Calcifications Vascular","enrollment":50},{"nctId":"NCT05387031","phase":"","title":"Efficacy of Ustekinumab Therapy in Patients With Symptomatic Stricturing Crohn's Disease","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2024-08-01","conditions":"Crohn Disease, Stricture; Bowel, Intestinal Stricture","enrollment":239},{"nctId":"NCT03774732","phase":"PHASE3","title":"PD-1 Inhibitor and Chemotherapy With Concurrent Irradiation at Varied Tumour Sites in Advanced Non-small Cell Lung Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"UNICANCER","startDate":"2018-01-24","conditions":"Non Small Cell Lung Cancer, Non Small Cell Lung Cancer Metastatic, Non-Small Cell Carcinoma of Lung, TNM Stage 4","enrollment":327},{"nctId":"NCT07424690","phase":"NA","title":"Catheter Ablation vs Conservative Care in Elderly Patients With Atrial Fibrillation","status":"NOT_YET_RECRUITING","sponsor":"Karolinska University Hospital","startDate":"2026-05-20","conditions":"Atrial Fibrillation (AF), Atrial Fibrillation Ablation, Elderly","enrollment":282},{"nctId":"NCT05041907","phase":"PHASE2","title":"Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)","status":"RECRUITING","sponsor":"University of Oxford","startDate":"2021-09-30","conditions":"COVID-19","enrollment":3800},{"nctId":"NCT05279079","phase":"","title":"Markers in Acute Pancreatitis-1","status":"COMPLETED","sponsor":"University of Liverpool","startDate":"2023-01-25","conditions":"Acute Pancreatitis Drug-Induced","enrollment":175},{"nctId":"NCT07408427","phase":"","title":"Precision Pharmacogenetics and Genotype Class Based Prediction of Mavacamten Response in Obstructive Hypertrophic Cardiomyopathy","status":"NOT_YET_RECRUITING","sponsor":"University of Manchester","startDate":"2026-06","conditions":"Hypertrophic Cardiomyopathy (HCM)","enrollment":140},{"nctId":"NCT07409259","phase":"EARLY_PHASE1","title":"PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver Failure","status":"ACTIVE_NOT_RECRUITING","sponsor":"Third Affiliated Hospital, Sun Yat-Sen University","startDate":"2026-01-01","conditions":"Acute-on-Chronic Liver Failure (ACLF)","enrollment":20},{"nctId":"NCT06489548","phase":"PHASE2","title":"Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease","status":"RECRUITING","sponsor":"Brigham and Women's Hospital","startDate":"2025-09-16","conditions":"Dementia, Alzheimers Disease, Mild Cognitive Impairment Due to Alzheimer's Disease","enrollment":16},{"nctId":"NCT07407803","phase":"PHASE3","title":"Evaluation of TQ-B3234 Capsules in Patients With Symptomatic, Non-Surgical Type 1 Neurofibromatosis-Associated Plexiform Neurofibromas","status":"NOT_YET_RECRUITING","sponsor":"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","startDate":"2026-02","conditions":"Plexiform Neurofibroma","enrollment":177},{"nctId":"NCT06678490","phase":"","title":"Support C Post-Market Registry","status":"ACTIVE_NOT_RECRUITING","sponsor":"OrbusNeich","startDate":"2025-07-09","conditions":"Coronary Arteriosclerosis","enrollment":282},{"nctId":"NCT05180695","phase":"PHASE1, PHASE2","title":"HDM201 and Pazopanib in Patients With P53 Wild-type Advanced/Metastatic Soft Tissue Sarcomas","status":"ACTIVE_NOT_RECRUITING","sponsor":"Centre Leon Berard","startDate":"2022-04-15","conditions":"Advanced Soft-tissue Sarcoma, Metastatic Soft-tissue Sarcoma","enrollment":47},{"nctId":"NCT06709339","phase":"PHASE4","title":"Study to Investigate the Efficacy, Safety and Durability of Faricimab in Caucasian Patients With Polypoidal Choroidal Vasculopathy (MONDEGO)","status":"RECRUITING","sponsor":"Association for Innovation and Biomedical Research on Light and Image","startDate":"2025-08-06","conditions":"Polypoidal Choroidal Vasculopathy","enrollment":120},{"nctId":"NCT04580134","phase":"PHASE4","title":"CLOZAPINE Response in Biotype-1","status":"RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2022-03-01","conditions":"Schizophrenia, Schizoaffective Disorder, Bipolar 1 Disorder","enrollment":524},{"nctId":"NCT03409588","phase":"PHASE2","title":"Treatment of Exercise-Induced Pulmonary Vascular Dysfunction After Pulmonary Thromboendarterectomy or Balloon Pulmonary Angioplasty","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2018-06-13","conditions":"Chronic Thromboembolic Disease (CTED), Exercise Intolerance Post PEA Surgery","enrollment":10},{"nctId":"NCT06871904","phase":"PHASE1, PHASE2","title":"Fibrosis-Modulating Effects of Metformin and Pirfenidone in Oral Submucous Fibrosis","status":"COMPLETED","sponsor":"Ziauddin University","startDate":"2025-04-07","conditions":"Oral Submucous Fibrosis","enrollment":45},{"nctId":"NCT07181369","phase":"PHASE1","title":"A Phase 1 Study of GTX-B001 in Healthy Subjects and Patients With Chronic Inducible Urticaria","status":"RECRUITING","sponsor":"Granular Therapeutics Limited","startDate":"2025-10-06","conditions":"Healthy Subjects, Cold Urticaria, Symptomatic Dermographism","enrollment":72},{"nctId":"NCT05401630","phase":"NA","title":"Mental Stress Reactivity in Women With CMD","status":"RECRUITING","sponsor":"Emory University","startDate":"2022-07-19","conditions":"Post-menopause","enrollment":150},{"nctId":"NCT05832762","phase":"NA","title":"Evaluation of Acute Endovascular Treatment in Symptomatic Isolated Cervical Internal Carotid Artery Occlusion (ETICA)","status":"RECRUITING","sponsor":"University Hospital, Montpellier","startDate":"2024-08-19","conditions":"Acute Ischemic Stroke","enrollment":200},{"nctId":"NCT06366087","phase":"PHASE1","title":"Sublingual Atropine Bioequivalence by Route of Administration (SABER)","status":"COMPLETED","sponsor":"Biomedical Advanced Research and Development Authority","startDate":"2024-04-15","conditions":"Atropine Bioequivalence","enrollment":46},{"nctId":"NCT07368933","phase":"NA","title":"Advanced NanoTherapies Dual-API DCB to Treat De-Novo and ISR Lesions in Patients With Symptomatic Coronary Artery Disease","status":"RECRUITING","sponsor":"Advanced NanoTherapies","startDate":"2025-12-15","conditions":"Angina (Stable), CAD - Coronary Artery Disease, Unstable Angina","enrollment":30},{"nctId":"NCT07358767","phase":"NA","title":"Impact of Malaria Mass Drug Administration on Malaria Prevalence in Under 15 Children and Pregnant Women","status":"COMPLETED","sponsor":"Noguchi Memorial Institute for Medical Research","startDate":"2021-07-01","conditions":"Malaria","enrollment":3300},{"nctId":"NCT07349979","phase":"NA","title":"PCI With Guideline-Directed Medical Therapy for HFpEF Patients With Ischemic Cardiomyopathy","status":"NOT_YET_RECRUITING","sponsor":"Nanjing First Hospital, Nanjing Medical University","startDate":"2026-01-30","conditions":"Heart Failure With Reduced Ejection Fraction, Coronary Artery Disease","enrollment":654},{"nctId":"NCT07157007","phase":"PHASE2","title":"Early-stage Trial to Determine a Safe and Effective Dose for Ratutrelvir in Patients With Mild to Moderate COVID-19","status":"RECRUITING","sponsor":"Traws Pharma, Inc.","startDate":"2025-09-16","conditions":"COVID - 19","enrollment":90},{"nctId":"NCT06144632","phase":"NA","title":"A Study of the THERMOCOOL SMARTTOUCH Surround Flow (SF) Catheter With the TRUPULSE Generator for Treatment of Drug Refractory Symptomatic PAF","status":"COMPLETED","sponsor":"Biosense Webster, Inc.","startDate":"2023-12-07","conditions":"Drug Refractory Paroxysmal Atrial Fibrillation","enrollment":237},{"nctId":"NCT06676072","phase":"NA","title":"A Study of the TactiFlex SE Catheter and Volt PFA Generator in Subjects With PAF:","status":"ACTIVE_NOT_RECRUITING","sponsor":"Abbott Medical Devices","startDate":"2024-11-22","conditions":"Atrial Fibrillation (AF), Atrial Arrhythmia, Paroxysmal AF","enrollment":188},{"nctId":"NCT07126951","phase":"NA","title":"Pilot Study: Clinical Trial of Ultrasound Guiding Pharmacopuncture Therapy for Acute Low Back Pain","status":"NOT_YET_RECRUITING","sponsor":"Jaseng Medical Foundation","startDate":"2026-03-30","conditions":"Low Back Pain (LBP)","enrollment":40},{"nctId":"NCT02616302","phase":"PHASE2","title":"A Study to Check the Safety of Dexlansoprazole and Learn if it Can Treat Symptomatic Nonerosive Gastroesophageal Reflux Disease in Children 2 to 11 Years Old","status":"RECRUITING","sponsor":"Takeda","startDate":"2023-02-20","conditions":"Gastroesophageal Reflux Disease (GERD)","enrollment":70},{"nctId":"NCT07332936","phase":"NA","title":"Tobradex as Intracanal Medicament","status":"COMPLETED","sponsor":"Umm Al-Qura University","startDate":"2023-07-01","conditions":"Symptomatic Irreversible Pulpitis, Postoperative Endodontic Pain Following Emergency Root Canal Treatment","enrollment":43},{"nctId":"NCT04408430","phase":"NA","title":"The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).","status":"RECRUITING","sponsor":"Mayra Guerrero","startDate":"2021-03-08","conditions":"Mitral Annular Calcification, Mitral Stenosis, Mitral Regurgitation","enrollment":210},{"nctId":"NCT07321899","phase":"NA","title":"Transcatheter Tricuspid Valve Replacement With the Medtronic Intrepid™ Transcatheter Tricuspid Valve Replacement (TTVR) System in Severe Tricuspid Regurgitation","status":"NOT_YET_RECRUITING","sponsor":"Medtronic Cardiovascular","startDate":"2026-06","conditions":"Severe Tricuspid Regurgitation","enrollment":1186},{"nctId":"NCT05687877","phase":"","title":"Evusheld Japan PMS_Japan Post-Marketing Surveillance (PMS)","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2023-01-06","conditions":"SARS-CoV-2 Infection","enrollment":366},{"nctId":"NCT04449406","phase":"","title":"Early Detection of Pancreatic Adenocarcinoma (PDAC) Using a Panel of Biomarkers","status":"RECRUITING","sponsor":"Queen Mary University of London","startDate":"2020-01-01","conditions":"Pancreatic Ductal Adenocarcinoma","enrollment":3500},{"nctId":"NCT05552963","phase":"NA","title":"A Study of Multi-electrode Circular Irreversible Electroporation (IRE) Catheter and Multi-Channel IRE Generator in Paroxysmal Atrial Fibrillation (AF)","status":"COMPLETED","sponsor":"Biosense Webster, Inc.","startDate":"2022-12-07","conditions":"Refractory Paroxysmal Atrial Fibrillation","enrollment":142},{"nctId":"NCT07311772","phase":"PHASE3","title":"Prevention and Treatment of Radiation-Induced Oral Mucositis in NPC With Houyanqing Oral Liquid","status":"RECRUITING","sponsor":"Sun Yat-sen University","startDate":"2025-12-15","conditions":"Nasopharyngeal Cancinoma (NPC), Radiation-induced Oral Mucositis","enrollment":244},{"nctId":"NCT07307118","phase":"NA","title":"Functional Hip Strength Improvement in Knee Osteoarthritis Following Single-Dose PRP and a 6-Week Home Exercise Program","status":"COMPLETED","sponsor":"Firat University","startDate":"2025-07-08","conditions":"Knee Osteoarthritis (OA)","enrollment":27},{"nctId":"NCT05978180","phase":"NA","title":"Safety of Use and Efficacy of Pandora for Patients Suffering From Gonarthrosis (PANDORA2)","status":"COMPLETED","sponsor":"Labrha","startDate":"2023-10-18","conditions":"Knee Osteoarthritis","enrollment":252},{"nctId":"NCT07296354","phase":"PHASE4","title":"Evaluation of an ATP-Containing Parenteral Vitamin B Complex in Patients With Symptomatic Diabetic Polyneuropathy","status":"NOT_YET_RECRUITING","sponsor":"Egyptian International Pharmaceutical Industries Co","startDate":"2026-01-10","conditions":"Neuropathic Pain","enrollment":200},{"nctId":"NCT05299658","phase":"PHASE2","title":"An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS","status":"ACTIVE_NOT_RECRUITING","sponsor":"Clene Nanomedicine","startDate":"2021-11-13","conditions":"Amyotrophic Lateral Sclerosis","enrollment":40},{"nctId":"NCT05637710","phase":"PHASE3","title":"Parallel, Double-dummy, Superiority Study Levocetirizine/Pseudoephedrine x Zina for Allergic Rhinitis in Brazil","status":"WITHDRAWN","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2026-03","conditions":"Allergic Rhinitis","enrollment":""},{"nctId":"NCT05309668","phase":"PHASE1, PHASE2","title":"Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN","status":"ACTIVE_NOT_RECRUITING","sponsor":"AstraZeneca","startDate":"2022-01-21","conditions":"Neurofibromatosis Type 1","enrollment":36},{"nctId":"NCT07271056","phase":"NA","title":"Sublingual Misoprostol Versus No Cervical Priming Before Hysteroscopic Resection of Symptomatic Uterine Niches","status":"COMPLETED","sponsor":"Benha University","startDate":"2025-02-11","conditions":"Scar Niche, Abnormal Uterine Bleeding, Cesarean Section Complications","enrollment":56},{"nctId":"NCT05883462","phase":"EARLY_PHASE1","title":"Paclitaxel-Coated Nasal Balloon for the Treatment of Recurrent Chronic Rhinosinusitis With or Without Nasal Polyps (FIH)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Airiver Medical, Inc.","startDate":"2023-06-07","conditions":"Chronic Rhinosinusitis","enrollment":45},{"nctId":"NCT07273864","phase":"NA","title":"Effect of Median Nerve Electrical Stimulation Combined With Auricular Acupuncture on Consciousness Disturbance in Patients With Craniocerebral Injury","status":"COMPLETED","sponsor":"Li Hai","startDate":"2022-02-10","conditions":"Traumatic Brain Injury, Cerebral Hemorrhage","enrollment":60},{"nctId":"NCT05865600","phase":"NA","title":"Perfusion Estimation For Optimal Treatment Strategy in Chronic Coronary Syndrome","status":"RECRUITING","sponsor":"Gødstrup Hospital","startDate":"2023-05-23","conditions":"Chronic Coronary Syndrome, Myocardial Ischemia, Stable Angina","enrollment":570},{"nctId":"NCT06272981","phase":"NA","title":"A Study of the THERMOCOOL SMARTTOUCH Surround Flow (SF) Catheter With the TRUPULSE Generator for Treatment of Drug Refractory Symptomatic PAFOUS","status":"COMPLETED","sponsor":"Biosense Webster, Inc.","startDate":"2024-02-28","conditions":"Atrial Fibrillation","enrollment":135},{"nctId":"NCT07272148","phase":"","title":"The Pilot of the Turku Outpatient Clinic for Functional and Fatigue Disorders","status":"ACTIVE_NOT_RECRUITING","sponsor":"Turku University Hospital","startDate":"2023-08-01","conditions":"Persistent Physical Symptoms (PPS), Functional Disorder, Fatigue Syndrome, Chronic","enrollment":125},{"nctId":"NCT02035293","phase":"NA","title":"Frequency of Diagnostic Symptomatic Pulmonary Embolism's in Patients Hospitalized for Clinical Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)","status":"COMPLETED","sponsor":"University Hospital, Brest","startDate":"2014-01-08","conditions":"Chronic Obstructive Pulmonary Disease, Patients Hospitalized for a COPD Exacerbation","enrollment":750},{"nctId":"NCT06505798","phase":"NA","title":"Cryoballoon/Radiofrequency/Pulsed Field Ablation of Atrial Fibrillation Versus Medical Treatment for Heart","status":"RECRUITING","sponsor":"University College, London","startDate":"2024-11-21","conditions":"Atrial Fibrillation (AF)","enrollment":1200},{"nctId":"NCT06857045","phase":"NA","title":"Comparison Three vs Six Months of Dual Anti-platelet Therapy After Sirolimus-eluting Stent Implantation","status":"WITHDRAWN","sponsor":"Sino Medical Sciences Technology Inc.","startDate":"2024-07-09","conditions":"Intracranial Arteriosclerosis, Intracranial Artery Stenosis, Drug-Eluting Stents","enrollment":""},{"nctId":"NCT03576690","phase":"","title":"R3470-3471-3479 (REGN-EB3) Expanded Access Protocol (EAP) for Treatment of Ebola Virus Disease","status":"AVAILABLE","sponsor":"Regeneron Pharmaceuticals","startDate":"","conditions":"Ebola Virus Disease","enrollment":""},{"nctId":"NCT07091682","phase":"NA","title":"Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold System in the Treatment of Subjects With Long de Novo Lesions","status":"RECRUITING","sponsor":"Biotronik AG","startDate":"2025-02-18","conditions":"Coronary Artery Disease, Atherosclerosis of Coronary Artery, Myocardial Ischemia","enrollment":100},{"nctId":"NCT07242846","phase":"PHASE4","title":"EFFECT OF INTRAARTICULAR TRIAMCINOLONE HEXACETONIDE AND BETAMETHASONE ON INTRAOCULAR PRESSURE","status":"COMPLETED","sponsor":"Nigde Omer Halisdemir University","startDate":"2025-10-02","conditions":"Knee Osteoarthritis (Knee OA), Intraocular Pressure","enrollment":80},{"nctId":"NCT04679740","phase":"","title":"Resorbable Magnesium Scaffolds Registry","status":"RECRUITING","sponsor":"Biotronik AG","startDate":"2020-11-18","conditions":"Coronary Artery Disease","enrollment":1106},{"nctId":"NCT06298383","phase":"NA","title":"The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain","status":"RECRUITING","sponsor":"Cairo University","startDate":"2025-06-15","conditions":"Symptomatic Irreversible Pulpitis","enrollment":120},{"nctId":"NCT07233564","phase":"NA","title":"Comparison of Pain Between Supraperiosteal Injection of Dexamethasone Versus Placebo on Postoperative Pain in Teeth With Symptomatic Irreversible Pulpitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"College of Physicians and Surgeons Pakistan","startDate":"2025-07-15","conditions":"Irreversible Pulpitis","enrollment":44},{"nctId":"NCT05690841","phase":"PHASE3","title":"FocaL Mass Drug Administration for Vivax Malaria Elimination","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2024-10-14","conditions":"Plasmodium Vivax Malaria, Malaria","enrollment":7530},{"nctId":"NCT06079320","phase":"PHASE2, PHASE3","title":"A Study to Learn About the Study Medicine Sisunatovir in Adults With Respiratory Syncytial Virus (RSV) Infection","status":"TERMINATED","sponsor":"Pfizer","startDate":"2023-12-08","conditions":"Respiratory Syncytial Virus Infection","enrollment":16},{"nctId":"NCT06324201","phase":"","title":"The Long-term Safety and Effectiveness Evaluation of the QDOT MICRO System Use in Conjunction With VISITAG SURPOINT Module for the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation.","status":"RECRUITING","sponsor":"Heart Rhythm Clinical and Research Solutions, LLC","startDate":"2024-02-27","conditions":"Paroxysmal Atrial Fibrillation","enrollment":250},{"nctId":"NCT05081388","phase":"PHASE1, PHASE2","title":"COVID-19 Study to Evaluate Safety, Tolerability, and Efficacy of REGN14256+Imdevimab for the Treatment of COVID-19 Adult and Adolescent Patients Without Risk Factors for Progression to Severe Disease","status":"TERMINATED","sponsor":"Regeneron Pharmaceuticals","startDate":"2021-11-08","conditions":"SARS-CoV-2","enrollment":25},{"nctId":"NCT05818150","phase":"NA","title":"GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA (MOTION)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Merit Medical Systems, Inc.","startDate":"2024-01-16","conditions":"Knee Osteoarthritis","enrollment":264},{"nctId":"NCT04543188","phase":"PHASE1","title":"A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement","status":"TERMINATED","sponsor":"Pfizer","startDate":"2021-01-08","conditions":"Malignant Melanoma, Carcinoma, Non-Small-Cell Lung, Brain Neoplasms, Primary","enrollment":65},{"nctId":"NCT05932615","phase":"NA","title":"ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation","status":"ENROLLING_BY_INVITATION","sponsor":"Abbott Medical Devices","startDate":"2024-03-15","conditions":"Aortic Valve Stenosis, Heart Valve Diseases, Aortic Valve Disease","enrollment":1500},{"nctId":"NCT06566170","phase":"","title":"A Real-World Comparative Study of Donanemab (LY3002813) Plus Usual Care Versus Usual Care Alone in US Participants With Early Symptomatic Alzheimer's Disease","status":"RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2024-10-07","conditions":"Alzheimer Disease","enrollment":6250},{"nctId":"NCT07214181","phase":"","title":"Topical Amitriptyline 1% Gel for the Treatment of Burning Mouth Syndrome","status":"COMPLETED","sponsor":"Universidad de Murcia","startDate":"2024-01-02","conditions":"Burning Mouth Syndrome, Stomatodynia","enrollment":30},{"nctId":"NCT04111627","phase":"PHASE2","title":"Exercise Plus Duloxetine for Knee Osteoarthritis","status":"COMPLETED","sponsor":"University of Maryland, Baltimore","startDate":"2021-10-07","conditions":"Knee Osteoarthritis, Depression","enrollment":43},{"nctId":"NCT04635111","phase":"","title":"A Long-term Study Evaluating Hepatotoxicity Associated With TURALIO™ (Pexidartinib) Treatment","status":"RECRUITING","sponsor":"Daiichi Sankyo","startDate":"2021-01-07","conditions":"Hepatotoxicity, Tenosynovial Giant Cell Tumor","enrollment":30},{"nctId":"NCT05521542","phase":"NA","title":"Advanced NanoTherapies Dual-API DCB to Treat De-Novo Lesions in Patients With Symptomatic Coronary Artery Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"Advanced NanoTherapies","startDate":"2023-01-30","conditions":"Coronary Artery Disease","enrollment":28},{"nctId":"NCT07202832","phase":"NA","title":"Urine Alkalinization for UTI in Women: RCT","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-10-15","conditions":"UTI - Urinary Tract Infection","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":327,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Symptomatic drugs","genericName":"Symptomatic drugs","companyName":"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta","companyId":"fondazione-i-r-c-c-s-istituto-neurologico-carlo-besta","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Riociguat, a hydrolytic enzyme inhibitor, is used to treat symptomatic conditions such as pulmonary hypertension associated with idiopathic interstitial pneumonias and benign prostatic hyperplasia. It works by inhibiting the enzyme methotrexate hydrolytic enzyme, which is involved in folate metabolism.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}