{"id":"switch-nph-to-glargin","brandName":"switch NPH to glargin","genericName":"switch NPH to glargin","companyId":"les-laboratoires-des-m-dicaments-st-riles","companyName":"Les Laboratoires des Médicaments Stériles","phase":"marketed","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Glargine, a small molecule insulin, has been studied as a potential replacement for NPH insulin in the treatment of Diabetes Mellitus. A clinical trial (NCT06999551) compared the efficacy and safety of glargine to NPH insulin in diabetic patients.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Insulin glargine is a recombinant human insulin analog modified to have a prolonged duration of action (up to 24 hours). It binds to the insulin receptor on target cells, facilitating glucose transport into muscle and adipose tissue while inhibiting gluconeogenesis and glycogenolysis in the liver. This switch from NPH (neutral protamine Hagedorn) insulin represents a transition from an intermediate-acting to a long-acting basal insulin formulation.","oneSentence":"Insulin glargine is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake and storage in peripheral tissues and suppressing hepatic glucose production.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Hypoglycemia"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Lipodystrophy"}]},"trials":[],"indications":{"approved":[{"name":"Type 1 diabetes mellitus"},{"name":"Type 2 diabetes mellitus"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}