{"id":"swab-area-with-chloraprep","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or erythema"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Transient burning sensation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ChloraPrep combines chlorhexidine gluconate (a broad-spectrum antimicrobial agent) with isopropyl alcohol to provide rapid and sustained skin antisepsis. Chlorhexidine disrupts bacterial cell membranes and denatures proteins, while the alcohol component provides rapid microbicidal activity. This combination is used to reduce the risk of surgical site infections and other skin-related infections by eliminating pathogenic microorganisms at the application site.","oneSentence":"ChloraPrep is a topical antiseptic that kills microorganisms on the skin surface through the antimicrobial action of chlorhexidine gluconate and isopropyl alcohol.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:10:28.871Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Skin antisepsis prior to surgical procedures"},{"name":"Skin preparation for injection sites and medical procedures"}]},"trialDetails":[{"nctId":"NCT00799812","phase":"PHASE3","title":"Test for Pre Operative Skin Preparations","status":"COMPLETED","sponsor":"C. R. Bard","startDate":"2007-11-13","conditions":"Topical Antisepsis","enrollment":335},{"nctId":"NCT01321125","phase":"PHASE3","title":"Chlorhexidine Against Sodium Hypochlorite as Skin Antiseptics","status":"COMPLETED","sponsor":"Universidad de Guanajuato","startDate":"2011-04","conditions":"Infectious Diseases","enrollment":30},{"nctId":"NCT01184196","phase":"PHASE4","title":"ChloraPrep Versus Betadine for Elective Knee Replacement Surgery","status":"TERMINATED","sponsor":"Central DuPage Hospital","startDate":"2009-11","conditions":"Arthroplasty, Knee Replacement, Replacement, Total Knee, Total Knee Replacement","enrollment":55}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Chlorhexadine Gluconate"],"phase":"marketed","status":"active","brandName":"Swab area with ChloraPrep","genericName":"Swab area with ChloraPrep","companyName":"Central DuPage Hospital","companyId":"central-dupage-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ChloraPrep is a small molecule used for topical antisepsis, specifically in conditions such as arthroplasty and total knee replacement surgery. It is typically applied by swabbing the area with a solution containing chlorhexidine gluconate and isopropyl alcohol.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}