{"id":"surgery-with-naproxen-and-esomeprazole","safety":{"commonSideEffects":[{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Gastrointestinal bleeding (reduced with PPI co-therapy)"}]},"_chembl":{"chemblId":"CHEMBL5314366","moleculeType":"Small molecule","molecularWeight":"769.20"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing pain and inflammation following surgical procedures. Esomeprazole is a proton pump inhibitor that blocks H+/K+-ATPase in gastric parietal cells, reducing gastric acid secretion to mitigate NSAID-induced gastrointestinal injury and ulceration risk.","oneSentence":"Naproxen reduces post-surgical pain and inflammation via COX inhibition, while esomeprazole protects the gastrointestinal tract by suppressing gastric acid production.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:10:19.810Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Post-surgical pain and inflammation with gastroprotection"}]},"trialDetails":[{"nctId":"NCT02494856","phase":"PHASE4","title":"Comparison of the Clinical Efficacy of Naproxen, Associated or Not With Esomeprazol, in Lower Third Molar Removal","status":"COMPLETED","sponsor":"Giovana Maria Weckwerth","startDate":"2014-10","conditions":"Pain, Other Surgical Procedures, Impacted Third Molar Tooth","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lower third molar surgery with Naproxen and Esomeprazole"],"phase":"marketed","status":"active","brandName":"Surgery with Naproxen and Esomeprazole","genericName":"Surgery with Naproxen and Esomeprazole","companyName":"Giovana Maria Weckwerth","companyId":"giovana-maria-weckwerth","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Naproxen reduces post-surgical pain and inflammation via COX inhibition, while esomeprazole protects the gastrointestinal tract by suppressing gastric acid production. Used for Post-surgical pain and inflammation with gastroprotection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}