{"id":"supportive-care-prednisone","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Immunosuppression/increased infection risk"},{"rate":null,"effect":"Osteoporosis"},{"rate":null,"effect":"Mood disturbances"}]},"_chembl":{"chemblId":"CHEMBL15720","moleculeType":"Small molecule","molecularWeight":"358.43"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Prednisone is a corticosteroid that binds to glucocorticoid receptors, reducing production of pro-inflammatory cytokines and suppressing T-cell and B-cell function. Supportive care encompasses symptomatic management, organ support, and general clinical interventions tailored to the patient's condition. Together, this combination addresses both the underlying inflammatory/immune pathology and clinical symptoms.","oneSentence":"Prednisone suppresses immune and inflammatory responses through glucocorticoid receptor activation, while supportive care provides symptomatic relief and organ support.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:36:48.716Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory or immune-mediated conditions requiring corticosteroid therapy (specific indication not publicly detailed)"}]},"trialDetails":[{"nctId":"NCT03819296","phase":"PHASE1","title":"Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2021-02-21","conditions":"Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8, Clinical Stage IA Cutaneous Melanoma AJCC v8","enrollment":800},{"nctId":"NCT03943901","phase":"PHASE2","title":"Split-Dose R-CHOP for Older Adults With DLBCL","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Wisconsin, Madison","startDate":"2021-02-17","conditions":"Diffuse Large B Cell Lymphoma, DLBCL, Cancer","enrollment":27},{"nctId":"NCT04151082","phase":"PHASE1, PHASE2","title":"High Dose Steroid Therapy (Prednisone or Methylprednisolone) for the Improvement of Symptoms of Late Radiation-Associated Lower Cranial Neuropathy in Oropharyngeal Cancer Survivors","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2019-10-16","conditions":"Cranial Nerve Disorder, Head and Neck Carcinoma, Oropharyngeal Carcinoma","enrollment":35},{"nctId":"NCT07049172","phase":"NA","title":"Rituximab and Targeted Nursing for Pediatric Nephrotic Syndrome","status":"COMPLETED","sponsor":"Wuhan Children's Hospital","startDate":"2021-01-01","conditions":"Nephrotic Syndrome in Children","enrollment":91},{"nctId":"NCT07064278","phase":"NA","title":"Combined Diagnostic Approach for Refractory Mycoplasma Pneumonia in Children","status":"COMPLETED","sponsor":"Children's Hospital of Hebei Province","startDate":"2022-12-01","conditions":"Refractory Mycoplasma Pneumoniae Pneumonia","enrollment":260},{"nctId":"NCT02043678","phase":"PHASE3","title":"Radium-223 Dichloride and Abiraterone Acetate Compared to Placebo and Abiraterone Acetate for Men With Cancer of the Prostate When Medical or Surgical Castration Does Not Work and When the Cancer Has Spread to the Bone, Has Not Been Treated With Chemotherapy and is Causing no or Only Mild Symptoms","status":"COMPLETED","sponsor":"Bayer","startDate":"2014-03-30","conditions":"Prostatic Neoplasms","enrollment":806},{"nctId":"NCT06405100","phase":"PHASE3","title":"Efficacy and Safety of Tacrolimus in Combination With Ripertamab in the Initial Treatment of Patients With MCD","status":"NOT_YET_RECRUITING","sponsor":"Air Force Military Medical University, China","startDate":"2024-05","conditions":"Minimal Change Disease","enrollment":81},{"nctId":"NCT02561273","phase":"PHASE1, PHASE2","title":"Combination Chemotherapy & Lenalidomide in Newly Diagnosed Stage II-IV Peripheral T-cell Non-Hodgkin's Lymphoma","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2015-09-28","conditions":"Anaplastic Large Cell Lymphoma, ALK-Negative, Anaplastic Large Cell Lymphoma, ALK-Positive, Hepatosplenic T-Cell Lymphoma","enrollment":54},{"nctId":"NCT05855395","phase":"NA","title":"The Standard of Care Combined With Glucocorticoid in Elderly People With Mild or Moderate COVID-19","status":"UNKNOWN","sponsor":"Huashan Hospital","startDate":"2023-05-26","conditions":"COVID-19","enrollment":5815},{"nctId":"NCT02188719","phase":"PHASE1","title":"Donor-Alloantigen-Reactive Regulatory T Cell (darTregs) in Liver Transplantation","status":"TERMINATED","sponsor":"National Institute of Allergy and Infectious Diseases 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Immunodeficiency Virus (HIV)","status":"COMPLETED","sponsor":"PETHEMA Foundation","startDate":"2006-10","conditions":"HIV Infections, Diffuse Large B Cell Lymphoma","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Control group"],"phase":"phase_3","status":"active","brandName":"Supportive care+Prednisone","genericName":"Supportive care+Prednisone","companyName":"Air Force Military Medical University, China","companyId":"air-force-military-medical-university-china","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prednisone is a small molecule used in supportive care, as indicated by its use in various clinical trials for conditions such as Diffuse Large B Cell Lymphoma and HIV Infections. It is often used in combination with other treatments, including R-CHOP and Highly active antiretroviral therapy, for conditions such as Head and Neck Carcinoma and Oropharyngeal Carcinoma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}