{"id":"supportive-and-immunosuppressive-therapy","safety":{"commonSideEffects":[{"rate":"null","effect":"Infections"},{"rate":"null","effect":"Nausea"},{"rate":"null","effect":"Vomiting"},{"rate":"null","effect":"Diarrhea"},{"rate":"null","effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL1628401","moleculeType":"Small molecule","molecularWeight":"657.81"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This type of therapy typically involves a combination of immunosuppressive medications, such as corticosteroids and calcineurin inhibitors, which work to reduce the activity of the immune system and prevent it from attacking the transplanted organ. Supportive care may include medications to manage symptoms such as pain, nausea, and fatigue, as well as treatments to prevent infections and other complications.","oneSentence":"Supportive and immunosuppressive therapy involves the use of medications to suppress the immune system and prevent rejection in organ transplant patients, while also providing supportive care to manage symptoms and improve quality of life.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:36:53.839Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of organ rejection in transplant patients"}]},"trialDetails":[{"nctId":"NCT04990323","phase":"PHASE1, PHASE2","title":"US Study of ECT-001-CB in Pediatric and Young Adult Patients With High-Risk Myeloid Malignancies","status":"COMPLETED","sponsor":"ExCellThera inc.","startDate":"2021-12-01","conditions":"High Risk Myeloid Malignancies, Cord Blood Transplant","enrollment":13},{"nctId":"NCT06795893","phase":"","title":"The Anifrolumab PRIM Program","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2025-11-07","conditions":"Systemic Lupus Erythematosus","enrollment":240},{"nctId":"NCT03835312","phase":"NA","title":"Sequential Transplantation of UCBSCs and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency T1DM","status":"RECRUITING","sponsor":"Children's Hospital of Fudan University","startDate":"2019-02-20","conditions":"Diabetes Mellitus, Type 1, Immunologic Deficiency Syndromes","enrollment":50},{"nctId":"NCT06859424","phase":"PHASE2","title":"A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation","status":"RECRUITING","sponsor":"Center for International Blood and Marrow Transplant Research","startDate":"2025-07-25","conditions":"AML (Acute Myelogenous Leukemia), Acute Lymphoid Leukemia (ALL), Acute Leukemia (Category)","enrollment":358},{"nctId":"NCT06659029","phase":"","title":"Prospective Registry Investigating Maternal and Infant Outcomes in Anifrolumab Users","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2025-07-01","conditions":"Systemic Lupus Erythematosus","enrollment":442},{"nctId":"NCT06594068","phase":"PHASE4","title":"Prospective Registry Investigating Maternal, Infant, and Lactation Outcomes in Anifrolumab Users","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2026-01-16","conditions":"Systemic Lupus Erythematosus","enrollment":16},{"nctId":"NCT00716066","phase":"PHASE2","title":"Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fred Hutchinson Cancer Center","startDate":"2008-06","conditions":"Autoimmune Disease, Neurologic Autoimmune Disease, Autologous Transplant Autoimmune","enrollment":53},{"nctId":"NCT07431775","phase":"","title":"Saphnelo Use in Females of Child-bearing Potential","status":"NOT_YET_RECRUITING","sponsor":"AstraZeneca","startDate":"2026-10-01","conditions":"Systemic Lupus Erythematosus","enrollment":26000000},{"nctId":"NCT07430449","phase":"NA","title":"The Effect of Education Given According to Roy's Adaptation Model","status":"COMPLETED","sponsor":"Trakya University","startDate":"2024-11-01","conditions":"Chronic Kidney Disease, Immunosuppressive Therapy","enrollment":78},{"nctId":"NCT04761770","phase":"PHASE2","title":"Study of a Geriatric Assessment to Plan a Treatment Approach for Older People With Various Blood Disorders","status":"ACTIVE_NOT_RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2021-02-15","conditions":"Myelodysplastic Syndrome, Myeloproliferative Neoplasms, Chronic Myelomonocytic Leukemia","enrollment":33},{"nctId":"NCT07089420","phase":"","title":"ALPCO/Calprotectin CLIA Assay: Expected Values of Calprotectin in Healthy Subjects","status":"RECRUITING","sponsor":"American Laboratory Products Company","startDate":"2025-07-07","conditions":"IBD (Inflammatory Bowel Disease), IBS - Irritable Bowel Syndrome, Crohn Disease (CD)","enrollment":120},{"nctId":"NCT06072482","phase":"PHASE4","title":"A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis","status":"RECRUITING","sponsor":"Amgen","startDate":"2024-02-07","conditions":"Antineutrophil Cytoplasmic Antibody-associated Vasculitis","enrollment":300},{"nctId":"NCT07364123","phase":"NA","title":"Kidney Transplant Immunosuppressive Therapy Adherence Trial (KITE)","status":"NOT_YET_RECRUITING","sponsor":"University of Gaziantep","startDate":"2026-01-05","conditions":"Kidney Transplantation, Medication Non-Adherence, Immunosuppressive Therapy","enrollment":60},{"nctId":"NCT07102849","phase":"","title":"Molecular and Clinical Analysis of Bone Marrow Failure: A Secondary Research Study","status":"ENROLLING_BY_INVITATION","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"2025-09-09","conditions":"Bone Marrow Failure Disorders, VEXAS Syndrome, Hemoglobinurea, Paroxysmal","enrollment":1400},{"nctId":"NCT05860400","phase":"","title":"Efficacy and Safety of Comprehensive Treatment in Patients With IR-CAD: a Self-controlled Cohort Study","status":"RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2023-05-17","conditions":"Coronary Artery Disease, Coronary Artery Stenosis, Coronary Artery Restenosis","enrollment":39},{"nctId":"NCT06845410","phase":"","title":"Clinical Features, Current Treatment and Clinical Outcomes in Patients With INR-CAD: a Cohort Study","status":"RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2025-04-01","conditions":"Coronary Artery Disease, Coronary Artery Disease Progression, Coronary Artery Stenosis","enrollment":120},{"nctId":"NCT01909245","phase":"PHASE2","title":"Islet Cell Transplant for Type 1 Diabetes","status":"ACTIVE_NOT_RECRUITING","sponsor":"City of Hope Medical Center","startDate":"2013-10-16","conditions":"Type 1 Diabetes Mellitus","enrollment":10},{"nctId":"NCT06673134","phase":"","title":"Prospective Cohort Establishment and Clinical Observation of Children With Crohn's Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"Tongji Hospital","startDate":"2023-12-01","conditions":"Crohn Disease","enrollment":100},{"nctId":"NCT07098897","phase":"PHASE3","title":"To Evaluate the Effect and Safety of Telitacicept and Standard Treatment for 6months in IgA Nephropathy","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Affiliated Hospital of Xuzhou Medical University","startDate":"2024-08-01","conditions":"IgA Nephropathy (IgAN)","enrollment":150},{"nctId":"NCT06825572","phase":"PHASE1","title":"MSC-EVs in Acute/ Acute-on-Chronic Liver Failure After Liver Transplantation","status":"NOT_YET_RECRUITING","sponsor":"Third Affiliated Hospital, Sun Yat-Sen University","startDate":"2025-04-01","conditions":"Liver Failure, Mesenchymal Stem Cell, Extracellular Vesicles","enrollment":30},{"nctId":"NCT03577431","phase":"PHASE1, PHASE2","title":"Liver Transplantation With Tregs at MGH","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2019-03-29","conditions":"Liver Transplant","enrollment":9},{"nctId":"NCT06613880","phase":"PHASE2","title":"Standard Immunosuppressive Therapy Combined With Romiplostim N01 as First-line Treatment for Severe Aplastic Anemia","status":"RECRUITING","sponsor":"Institute of Hematology & Blood Diseases Hospital, China","startDate":"2024-10-24","conditions":"Aplastic Anemia, TPO Receptor Agonists","enrollment":48},{"nctId":"NCT06637683","phase":"NA","title":"Efficacy of LiveSpo COLON as a Supportive Treatment for Inflammatory Bowel Disease (IBD)","status":"COMPLETED","sponsor":"Anabio R&D","startDate":"2019-11-15","conditions":"Inflammatory Bowel Diseases","enrollment":60},{"nctId":"NCT03418779","phase":"PHASE2, PHASE3","title":"Treatment Effects of Chinese Medicine (Yi-Qi-Qing-Jie Herbal Compound) Combined With Immunosuppression Therapies in IgA Nephropathy Patients With High-risk of ESRD","status":"ACTIVE_NOT_RECRUITING","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2019-07-04","conditions":"IgA Nephropathy at High Risk of Developing ESRD","enrollment":60},{"nctId":"NCT04521790","phase":"","title":"Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management","status":"RECRUITING","sponsor":"Scientific Institute San Raffaele","startDate":"2018-01-30","conditions":"Myocarditis, Ventricular Arrythmia, Inflammatory Cardiomyopathy","enrollment":1000},{"nctId":"NCT06591260","phase":"","title":"Role of Endomyocardial Biopsy and Aetiology-based Treatment in Pediatric Patients with Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management (MYOPED)","status":"RECRUITING","sponsor":"Scientific Institute San Raffaele","startDate":"2013-01-01","conditions":"Myocarditis, Ventricular Arrhythmia, Inflammatory Cardiomyopathy","enrollment":20},{"nctId":"NCT04288271","phase":"NA","title":"Teen Adherence in KidnEy Transplant Improving Tracking To Optimize Outcomes - Stage 3","status":"COMPLETED","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2022-02-04","conditions":"Medication Adherence, Kidney Transplantation","enrollment":96},{"nctId":"NCT05881668","phase":"PHASE1","title":"MSC-EV in Acute-on-Chronic Liver Failure After Liver Transplantation","status":"WITHDRAWN","sponsor":"Third Affiliated Hospital, Sun Yat-Sen University","startDate":"2023-09-30","conditions":"Liver Failure, Acute on Chronic","enrollment":""},{"nctId":"NCT06065852","phase":"","title":"National Registry of Rare Kidney Diseases","status":"RECRUITING","sponsor":"UK Kidney Association","startDate":"2009-11-06","conditions":"Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis, AHL Amyloidosis","enrollment":35000},{"nctId":"NCT01264315","phase":"PHASE2","title":"Safety And Efficacy Of Lenalidomide As Maintenance Therapy In Patients With Newly Diagnosed Multiple Myeloma Following A Tandem Autologous-Allogeneic Transplant","status":"COMPLETED","sponsor":"Fondazione EMN Italy Onlus","startDate":"2008-09","conditions":"Multiple Myeloma","enrollment":53},{"nctId":"NCT05277285","phase":"PHASE2","title":"STS Administration on Coronavirus Disease (COVID-19) Patients in Critical Care","status":"UNKNOWN","sponsor":"Hellenic Institute for the Study of Sepsis","startDate":"2022-04-01","conditions":"COVID-19, Virus Diseases, Corona Virus Infection","enrollment":30},{"nctId":"NCT01516593","phase":"PHASE2","title":"Short Term Intensified Chemo-immunotherapy in HIV-positive Patients With Burkitt Lymphoma","status":"COMPLETED","sponsor":"Andres J. M. Ferreri","startDate":"2011-11","conditions":"HIV, Burkitt's Lymphoma","enrollment":19},{"nctId":"NCT05367986","phase":"NA","title":"Electro-acupuncture at Zusanli, Qihai, and Guanyuan Acupoints Regulate Immune Function in Patients With Sepsis","status":"COMPLETED","sponsor":"Guangdong Provincial Hospital of Traditional Chinese Medicine","startDate":"2019-07-01","conditions":"Sepsis, Immune Dysfunction","enrollment":78},{"nctId":"NCT04715412","phase":"NA","title":"Clinical Pharmacy Guided Patient Counselling and Adherence Support on Renal Transplant Recipients","status":"COMPLETED","sponsor":"Future University in Egypt","startDate":"2020-03-10","conditions":"Transplant;Failure,Kidney","enrollment":60},{"nctId":"NCT04438603","phase":"","title":"The Applicaiton of Immune Repertoire in the Diagnosis and Disease Monitoring of IgA Nephropathy","status":"UNKNOWN","sponsor":"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","startDate":"2020-10-01","conditions":"IgA Nephropathy","enrollment":180},{"nctId":"NCT00303719","phase":"PHASE2","title":"Allogeneic Bone Marrow Transplantation Using Less Intensive Therapy","status":"TERMINATED","sponsor":"Masonic Cancer Center, University of Minnesota","startDate":"2002-03-26","conditions":"Kidney Cancer, Leukemia, Lymphoma","enrollment":342},{"nctId":"NCT00787722","phase":"PHASE1, PHASE2","title":"Hematopoietic Stem Cell Transplant in Devic's Disease","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2009-10-10","conditions":"Devic's Disease","enrollment":13},{"nctId":"NCT00104858","phase":"PHASE2","title":"Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma","status":"COMPLETED","sponsor":"Fred Hutchinson Cancer Center","startDate":"2004-12","conditions":"Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, Recurrent Small Lymphocytic Lymphoma","enrollment":66},{"nctId":"NCT02123836","phase":"PHASE1","title":"Natural Killer Cells in Acute Leukaemia and Myelodysplastic Syndrome","status":"UNKNOWN","sponsor":"National University Hospital, Singapore","startDate":"2014-04","conditions":"Acute Leukaemia, Myelodysplastic Syndrome","enrollment":20},{"nctId":"NCT03468972","phase":"PHASE4","title":"Effect of Immunosuppression in IgA Nephropathy","status":"UNKNOWN","sponsor":"Yonsei University","startDate":"2019-03","conditions":"Biopsy-proven IgA Nephropathy","enrollment":174},{"nctId":"NCT03567161","phase":"NA","title":"Ultrasonic Surgical Aspirator to Treat Deep Infrabony Defects","status":"COMPLETED","sponsor":"University of Milan","startDate":"2017-02-01","conditions":"Periodontitis","enrollment":11},{"nctId":"NCT03314909","phase":"NA","title":"Initial Hemopurification Strategy for Acute Paraquat Poisoning in Adults","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2018-10-01","conditions":"Poisoning","enrollment":360},{"nctId":"NCT03125772","phase":"NA","title":"Trial on Safety & Performance of TAXUS Element vs. XIENCE Prime Stent in Treatment of Coronary Lesion in Diabetics","status":"COMPLETED","sponsor":"Fortis Escorts Heart Institute","startDate":"2011-06","conditions":"Type 2 Diabetes, Coronary Heart Disease","enrollment":1830},{"nctId":"NCT02401932","phase":"","title":"Retrospective Analysis for Patients With Hemophagocytosis in Bone Marrow","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2014-01","conditions":"Hemophagocytosis","enrollment":300},{"nctId":"NCT00093678","phase":"NA","title":"Celecoxib in Managing Pain, Weight Loss, and Weakness in Patients With Advanced Cancer","status":"WITHDRAWN","sponsor":"Eastern Cooperative Oncology Group","startDate":"","conditions":"Cachexia, Lymphoma, Melanoma (Skin)","enrollment":""},{"nctId":"NCT00554502","phase":"PHASE3","title":"Supportive Versus Immunosuppressive Therapy for the Treatment Of Progressive IgA Nephropathy","status":"COMPLETED","sponsor":"RWTH Aachen University","startDate":"2008-02","conditions":"IgA Nephropathy","enrollment":148},{"nctId":"NCT01739803","phase":"NA","title":"Behavioral Contract Adherence Intervention","status":"COMPLETED","sponsor":"University of Tennessee","startDate":"2010-01","conditions":"Renal Transplantation","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":387,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"supportive and immunosuppressive therapy","genericName":"supportive and immunosuppressive therapy","companyName":"RWTH Aachen University","companyId":"rwth-aachen-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Supportive therapy is used to treat various conditions, including Multiple Myeloma, Renal Transplantation, Systemic Lupus Erythematosus, Sepsis, and Immune Dysfunction, as indicated by ClinicalTrials.gov. Immunomodulatory small molecules, such as Lenalidomide, are used in supportive therapy, as classified by ChEMBL, to modulate the immune system and treat these conditions.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}