{"id":"suplatast","rwe":[],"tags":[{"label":"suplatast","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anti-Allergic Agents","category":"pharmacology"},{"label":"Histamine Agents","category":"pharmacology"},{"label":"Histamine Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["suplatast tosylate","suplatast","suplatast tosilate"],"offLabel":[],"synonyms":["suplatast tosylate","suplatast","suplatast tosilate"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"suplatast","explanation":"Imagine your body's immune system is like a fire alarm that goes off when it senses something is wrong. Mast cells are like the alarm sensors that release chemical signals to alert the rest of the body. Suplatast tosilate helps to turn down the volume on these alarm signals, reducing the symptoms of asthma and allergic rhinitis.","oneSentence":"Suplatast tosilate works by inhibiting the release of chemical mediators from mast cells.","technicalDetail":"Suplatast tosilate is a selective inhibitor of the cysteinyl leukotriene receptor 1 (CysLT1R), which plays a key role in the pathophysiology of asthma and allergic rhinitis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2545","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=SUPLATAST","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SUPLATAST","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:45:39.972862","biosimilars":[],"competitors":[],"genericName":"suplatast","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT05983471","phase":"PHASE2","title":"Efficacy and Safety of ME-015 (Suplatast Tosilate) in Cough Related to Idiopathic Pulmonary Fibrosis (COSMIC-IPF)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Melius Pharma AB","startDate":"2024-04-01","conditions":["Idiopathic Pulmonary Fibrosis","Cough","IPF","Fibrotic Lung Disease","Chronic Cough","Coughing"],"enrollment":40,"completionDate":"2025-09"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"4T0HO29O56","CHEBI":"CHEBI:32172","INN_ID":"6709","UMLSCUI":"C0527067","ChEMBL_ID":"CHEMBL1180156","KEGG_DRUG":"D01423","PUBCHEM_CID":"71774","SECONDARY_CAS_RN":"94055-76-2","MESH_SUPPLEMENTAL_RECORD_UI":"C073028"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"SUPLATAST","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Suplatast tosilate is a small molecule intervention being studied for its efficacy and safety in treating conditions such as Idiopathic Pulmonary Fibrosis and Chronic Cough. It is being investigated in a randomized, double-blind, placebo-controlled trial as part of the COSMIC-IPF study.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}