{"id":"supersaturated-calcium-phosphate","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL2107567","moleculeType":"Small molecule","molecularWeight":"136.06"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This product delivers calcium and phosphate in a supersaturated state, which promotes the deposition of mineral onto tooth surfaces and into demineralized lesions. By restoring mineral content, it helps reverse early enamel erosion and caries damage, and supports the structural integrity of dental tissues. The supersaturation state enhances bioavailability compared to conventional calcium phosphate formulations.","oneSentence":"Supersaturated calcium phosphate releases bioavailable calcium and phosphate ions to remineralize and repair dental enamel and dentin.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:10:09.036Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dental enamel remineralization"},{"name":"Caries prevention and reversal of early caries lesions"},{"name":"Dentin hypersensitivity management"}]},"trialDetails":[{"nctId":"NCT02539342","phase":"PHASE3","title":"Caphosol Study: Prevention of Oral Mucositis in Children, Adolescents and Young Adults Receiving Chemotherapy","status":"TERMINATED","sponsor":"Medical College of Wisconsin","startDate":"2016-10","conditions":"Oral Mucositis","enrollment":1},{"nctId":"NCT02807337","phase":"PHASE2","title":"Supersaturated Calcium Phosphate Oral Rinse (Caphosol®) For the Prevention of Oral Mucositis in Children Undergoing Chemotherapeutic Treatments","status":"COMPLETED","sponsor":"Tampere University Hospital","startDate":"2016-08-01","conditions":"Cancer","enrollment":47},{"nctId":"NCT03932292","phase":"NA","title":"Ectoin® Mouth Wash (EML03) in the Prevention and Treatment of Radiation-induced Oral Mucositis","status":"COMPLETED","sponsor":"Bitop AG","startDate":"2018-12-18","conditions":"Oral Mucositis Due to Radiation","enrollment":52},{"nctId":"NCT01305200","phase":"PHASE3","title":"Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant","status":"COMPLETED","sponsor":"Children's Oncology Group","startDate":"2011-03","conditions":"Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission, Childhood Chronic Myelogenous Leukemia","enrollment":226},{"nctId":"NCT02107300","phase":"NA","title":"NeutraSal Treatment for Xerostomia in OSAS Patients Using CPAP Therapy","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2013-11","conditions":"Xerostomia","enrollment":32},{"nctId":"NCT01265810","phase":"PHASE3","title":"Caphosol in Oral Mucositis Due to Targeted Therapy","status":"COMPLETED","sponsor":"Impaqtt Foundation","startDate":"2011-11","conditions":"Oral Complaints, Renal Cell Carcinoma, Hepatocellular Carcinoma","enrollment":64},{"nctId":"NCT02662374","phase":"PHASE4","title":"Oral Hygiene Regimen in Patients on HCT","status":"UNKNOWN","sponsor":"Riyadh Colleges of Dentistry and Pharmacy","startDate":"2015-09","conditions":"Oral Mucositis","enrollment":45},{"nctId":"NCT01758562","phase":"NA","title":"Caphosol® Versus State-of-the-art Mouthcare in Patients With Allogeneic Stem Cell Transplantation: a Randomized Controlled Study About the Efficacy of the Mouth Rinse Caphosol®","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2013-01","conditions":"Allogeneic Stem Cell Transplantation","enrollment":72},{"nctId":"NCT00901732","phase":"PHASE1, PHASE2","title":"Caphosol for the Reduction of Mucositis in Patients Receiving Radiation Therapy for Head and Neck Cancer","status":"UNKNOWN","sponsor":"Jazz Pharmaceuticals","startDate":"2009-05","conditions":"Oral Mucositis","enrollment":100}],"_emaApprovals":[],"_faersSignals":[{"count":34,"reaction":"CYTOKINE RELEASE SYNDROME"},{"count":11,"reaction":"INFUSION RELATED REACTION"},{"count":8,"reaction":"NEUROTOXICITY"},{"count":1,"reaction":"BLOOD BILIRUBIN INCREASED"},{"count":1,"reaction":"CLOSTRIDIUM DIFFICILE COLITIS"},{"count":1,"reaction":"DERMATITIS"},{"count":1,"reaction":"DIARRHOEA"},{"count":1,"reaction":"DIFFUSE LARGE B-CELL LYMPHOMA"},{"count":1,"reaction":"ESCHERICHIA BACTERAEMIA"},{"count":1,"reaction":"FEBRILE NEUTROPENIA"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Moistir (Kingswood laboratories Inc., Indianapolis IN USA)"],"phase":"marketed","status":"active","brandName":"Supersaturated Calcium Phosphate","genericName":"Supersaturated Calcium Phosphate","companyName":"Riyadh Colleges of Dentistry and Pharmacy","companyId":"riyadh-colleges-of-dentistry-and-pharmacy","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Supersaturated calcium phosphate releases bioavailable calcium and phosphate ions to remineralize and repair dental enamel and dentin. Used for Dental enamel remineralization, Caries prevention and reversal of early caries lesions, Dentin hypersensitivity management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}