{"id":"sulphadoxine-pyrimethamine-amodiaquine-placebo-azithromycin","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Sulphadoxine-pyrimethamine works by inhibiting the growth of the malaria parasite, while amodiaquine interferes with the parasite's ability to synthesize DNA and RNA, ultimately leading to the death of the parasite. The combination of these two drugs is used to treat malaria.","oneSentence":"Sulphadoxine-pyrimethamine is a combination of a sulfonamide antibiotic and a dihydrofolate reductase inhibitor, while amodiaquine is an antimalarial drug that works by interfering with the parasite's ability to synthesize DNA and RNA.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:36:53.237Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of uncomplicated malaria"},{"name":"Treatment of severe malaria"}]},"trialDetails":[{"nctId":"NCT02211729","phase":"PHASE3","title":"A Trial of Seasonal Malaria Chemoprevention Plus Azithromycin in African Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2014-05","conditions":"Malaria, Respiratory Infections","enrollment":22090}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Sulphadoxine-pyrimethamine + amodiaquine + placebo azithromycin","genericName":"Sulphadoxine-pyrimethamine + amodiaquine + placebo azithromycin","companyName":"London School of Hygiene and Tropical Medicine","companyId":"london-school-of-hygiene-and-tropical-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sulphadoxine-pyrimethamine is a combination of a sulfonamide antibiotic and a dihydrofolate reductase inhibitor, while amodiaquine is an antimalarial drug that works by interfering with the parasite's ability to synthesize DNA and RNA. Used for Treatment of uncomplicated malaria, Treatment of severe malaria.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}