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The combination is particularly effective against Plasmodium species and Toxoplasma gondii.","oneSentence":"Sulphadoxine-pyrimethamine inhibits dihydrofolate reductase and dihydropteroate synthase in parasites, blocking folate synthesis and DNA replication.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:38:14.395Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria (Plasmodium falciparum and other Plasmodium species)"},{"name":"Toxoplasmosis prophylaxis and treatment"},{"name":"Pneumocystis jirovecii pneumonia prophylaxis"}]},"trialDetails":[{"nctId":"NCT04235816","phase":"PHASE3","title":"Improving Care Through Azithromycin Research for Infants in Africa","status":"ACTIVE_NOT_RECRUITING","sponsor":"Barcelona Institute for Global Health","startDate":"2021-03-15","conditions":"Child Mortality","enrollment":20560},{"nctId":"NCT05949190","phase":"NA","title":"Improving Cognition and Gestational Duration With Targeted 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