{"id":"sulfobromophthalein","rwe":[{"pmid":"34980776","year":"2022","title":"Directional Drug Transport through Membrane-Supported Monolayers of Human Liver-Derived Cell Lines.","finding":"","journal":"Biological & pharmaceutical bulletin","studyType":"Clinical Study"},{"pmid":"32964147","year":"2020","title":"Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells.","finding":"","journal":"Biochemistry and biophysics reports","studyType":"Clinical Study"},{"pmid":"29498478","year":"2018","title":"Interaction of Sulfonylureas with Liver Uptake Transporters OATP1B1 and OATP1B3.","finding":"","journal":"Basic & clinical pharmacology & toxicology","studyType":"Clinical Study"},{"pmid":"28552774","year":"2017","title":"Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides.","finding":"","journal":"Toxicology letters","studyType":"Clinical Study"},{"pmid":"27075600","year":"2016","title":"PARTICIPATION OF Y89 AND Y97 IN THE CONJUGATING ACTIVITY OF Drosophila melanogaster GLUTATHIONE S-TRANSFERASE D3 (DmGSTD3).","finding":"","journal":"Archives of insect biochemistry and physiology","studyType":"Clinical Study"}],"tags":[{"label":"sulfobromophthalein","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Hematopoietic prostaglandin D synthase","category":"target"},{"label":"HPGDS","category":"gene"},{"label":"V04CE02","category":"atc"},{"label":"Active","category":"status"},{"label":"Diagnostic aid","category":"indication"},{"label":"Coloring Agents","category":"pharmacology"},{"label":"Indicators and Reagents","category":"pharmacology"}],"phase":"unknown","safety":{"contraindications":["Acute nephropathy","Asthma","Hb SS disease","Hepatic failure","Hypertensive Emergencies","Kidney disease","Pheochromocytoma","Pregnancy, function"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bromosulphalein","offLabel":[],"synonyms":["sulfobromophthalein","sulphobromophthalein sodium","bromosulfophthalein","bromosulphalein","sodium sulfobromophthalein","phenoltetrabromophthaleinsulfonate","bromsulfophthalein","tetrabromsulfthalein"],"timeline":[],"approvals":[],"brandName":"Bromosulphalein","ecosystem":[{"indication":"Diagnostic aid","otherDrugs":[{"name":"ceruletide","slug":"ceruletide","company":"Pharmacia And Upjohn"},{"name":"iopanoic acid","slug":"iopanoic-acid","company":""},{"name":"iopodic acid","slug":"iopodic-acid","company":"Bracco"},{"name":"sincalide","slug":"sincalide","company":"Bracco"}],"globalPrevalence":null}],"mechanism":{"target":"Hematopoietic prostaglandin D synthase","targets":[{"gene":"HPGDS","source":"DrugCentral","target":"Hematopoietic prostaglandin D synthase","protein":"Hematopoietic prostaglandin D synthase"}],"modality":"Small Molecule","drugClass":"sulfobromophthalein","explanation":"Think of it like a key fitting into a lock. Bromosulphalein is the key that fits into the lock of the enzyme, preventing it from working properly. This helps doctors understand how well the liver is functioning.","oneSentence":"Bromosulphalein works by binding to and inhibiting the enzyme hematopoietic prostaglandin D synthase.","technicalDetail":"Bromosulphalein acts as a competitive inhibitor of hematopoietic prostaglandin D synthase, a key enzyme involved in the synthesis of prostaglandin D2, which plays a role in various physiological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2531","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=sulfobromophthalein","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=sulfobromophthalein","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:46:04.400850","biosimilars":[],"competitors":[],"genericName":"sulfobromophthalein","indications":{"approved":[{"name":"Diagnostic aid","source":"DrugCentral","snomedId":2949005,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT03315247","phase":"NA","title":"Tele-CBT Following Bariatric Surgery: Randomized Control Trial","status":"COMPLETED","sponsor":"University Health Network, 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Gastrointestinal Imaging Quality With Probe-based Confocal Laser Endomicroscopy","status":"UNKNOWN","sponsor":"Xijing Hospital of Digestive Diseases","startDate":"2013-12","conditions":["Gastrointestinal Imaging With pCLE"],"enrollment":150,"completionDate":"2016-12"},{"nctId":"NCT00930293","phase":"NA","title":"Efficacy and Feasibility of a Personalized Treatment for Depression With Co-Occurring Anxiety","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2009-07","conditions":["Depression","Anxiety"],"enrollment":50,"completionDate":"2012-06"},{"nctId":"NCT01185678","phase":"","title":"Data on Oral Contraceptives Compliance in Non Stop Regimen","status":"COMPLETED","sponsor":"Bayer","startDate":"2010-05","conditions":["Contraception"],"enrollment":8416,"completionDate":"2010-11"},{"nctId":"NCT01055002","phase":"PHASE1,PHASE2","title":"A Pilot Study to Test Activity of Antimalarial Drugs Against an Induced Malaria Infection in Healthy 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bulletin"},{"date":"2020 Dec","pmid":"32964147","title":"Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells.","journal":"Biochemistry and biophysics reports"},{"date":"2018 Aug","pmid":"29498478","title":"Interaction of Sulfonylureas with Liver Uptake Transporters OATP1B1 and OATP1B3.","journal":"Basic & clinical pharmacology & toxicology"},{"date":"2017 Aug 5","pmid":"28552774","title":"Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides.","journal":"Toxicology letters"},{"date":"2016 Jul","pmid":"27075600","title":"PARTICIPATION OF Y89 AND Y97 IN THE CONJUGATING ACTIVITY OF Drosophila melanogaster GLUTATHIONE S-TRANSFERASE D3 (DmGSTD3).","journal":"Archives of insect biochemistry and physiology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Bromosulphalein is a small molecule used in liver function tests, where its rate of removal from the bloodstream is measured to assess liver function. The liver detoxifies bromosulphalein by attaching it to glutathione, the body's master antioxidant.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}