{"id":"sulfiram","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Alcoholism","category":"indication"}],"phase":"phase_2","safety":{"contraindications":["Alcohol intoxication","Chronic glomerulonephritis","Chronic heart failure","Cirrhosis of liver","Cognitive Impairment following Traumatic Brain Injury","Conduction disorder of the heart","Coronary arteriosclerosis","Diabetes mellitus","Disease of liver","Epilepsy","Hypothyroidism","Nephritis","Psychotic disorder"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"tetrucid","offLabel":[],"synonyms":["sulfiram","sulfirame","sulfiramum","tetrucid"],"timeline":[],"approvals":[],"brandName":"Tetrucid","ecosystem":[{"indication":"Alcoholism","otherDrugs":[{"name":"acamprosate","slug":"acamprosate","company":"Forest Labs"},{"name":"disulfiram","slug":"disulfiram","company":""},{"name":"nalmefene","slug":"nalmefene","company":"Eurohlth Intl Sarl"},{"name":"naltrexone","slug":"naltrexone","company":"Teva Womens"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","explanation":"When you drink alcohol, your body breaks it down into a toxic compound called acetaldehyde. Tetrucid blocks the enzyme that's supposed to break down acetaldehyde, making you feel sick when you drink. This makes it less appealing to drink, which can help people stop or cut back on drinking.","oneSentence":"Tetrucid works by inhibiting the enzyme aldehyde dehydrogenase, which breaks down alcohol into a less toxic compound.","technicalDetail":"Tetrucid specifically inhibits the enzyme aldehyde dehydrogenase 2 (ALDH2), which is responsible for converting acetaldehyde to acetate in the liver. This leads to an accumulation of acetaldehyde, causing the unpleasant symptoms associated with Tetrucid treatment."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3569","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SULFIRAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:45:15.892468","biosimilars":[],"competitors":[],"genericName":"sulfiram","indications":{"approved":[{"name":"Alcoholism","source":"DrugCentral","snomedId":7200002,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004043","UNII":"1XHL4Q8P7Y","CHEBI":"CHEBI:135093","INN_ID":"4006","RXNORM":"30206","UMLSCUI":"C0066779","ChEMBL_ID":"CHEMBL2004297","KEGG_DRUG":"D08545","PUBCHEM_CID":"7215","SNOMEDCT_US":"333092000"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Gastroenterology"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tetrucid is a small molecule with the synonyms Sulfiram, Sulfiram, Sulfirame, and Tetmosol.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}