{"id":"sulfamonomethoxine","rwe":[{"pmid":"41883371","year":"2026","title":"Antibiotic Exposure and Early Reproductive Outcomes of In Vitro Fertilization (IVF) in a Chinese Couple-Based Preconception Cohort.","finding":"","journal":"Environment & health (Washington, D.C.)","studyType":"Clinical Study"},{"pmid":"41875559","year":"2026","title":"Joint effects of contaminants of emerging concern (CECs) on sleep quality in Chinese elderly: A Bayesian kernel machine regression and quantile g-computation analysis.","finding":"","journal":"Ecotoxicology and environmental safety","studyType":"Clinical Study"},{"pmid":"41412858","year":"2026","title":"Erratum to \"Molecular insights into anammox inhibition induced by environmentally relevant sulfamonomethoxine and functional recovery via voltage stimulation\" [Bioresour. Technol. 436 (2025) 133018].","finding":"","journal":"Bioresource technology","studyType":"Clinical Study"},{"pmid":"41246051","year":"2025","title":"TiO₂-modified activated carbon for pharmaceutical contaminant removal: experimental and in-silico insights using density functional theory.","finding":"","journal":"Journal of environmental health science & engineering","studyType":"Clinical Study"},{"pmid":"40795590","year":"2026","title":"Piezoelectric-driven self-powered sensor with tunable plasmonic hotspots for enhanced SERS performance.","finding":"","journal":"Journal of colloid and interface science","studyType":"Clinical Study"}],"tags":[{"label":"sulfamonomethoxine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"daimeton","offLabel":[],"synonyms":["daimeton","sulfamonomethoxine","sulfamonomethoxin"],"timeline":[],"approvals":[],"brandName":"Daimeton","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"sulfamonomethoxine","explanation":"Think of it like a roadblock: Daimeton blocks the bacteria's ability to make a crucial nutrient called folic acid, which is necessary for the bacteria to grow and multiply. Without folic acid, the bacteria can't survive and the infection is cleared. This is a common mechanism of action for many antibiotics, including sulfonamides like Daimeton.","oneSentence":"Daimeton works by inhibiting the bacterial enzyme dihydropteroate synthase, which is essential for the synthesis of folic acid.","technicalDetail":"Daimeton inhibits the bacterial enzyme dihydropteroate synthase (DHPS), which is involved in the synthesis of dihydrofolate (DHF) from para-aminobenzoic acid (PABA) and pteridine. This inhibition prevents the bacteria from producing tetrahydrofolate (THF), a critical cofactor for DNA synthesis and repair."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2519","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SULFAMONOMETHOXINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:44:54.592192","biosimilars":[],"competitors":[],"genericName":"sulfamonomethoxine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"U700P169W2","CHEBI":"CHEBI:32164","INN_ID":"1020","UMLSCUI":"C0038699","ChEMBL_ID":"CHEMBL462990","KEGG_DRUG":"D01141","PDB_CHEM_ID":"K4Y","PUBCHEM_CID":"5332","IUPHAR_LIGAND_ID":"12688","MESH_DESCRIPTOR_UI":"D013422"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":255,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 20","pmid":"41883371","title":"Antibiotic Exposure and Early Reproductive Outcomes of In Vitro Fertilization (IVF) in a Chinese Couple-Based Preconception Cohort.","journal":"Environment & health (Washington, D.C.)"},{"date":"2026 Mar 23","pmid":"41875559","title":"Joint effects of contaminants of emerging concern (CECs) on sleep quality in Chinese elderly: A Bayesian kernel machine regression and quantile g-computation analysis.","journal":"Ecotoxicology and environmental safety"},{"date":"2026 Feb","pmid":"41412858","title":"Erratum to \"Molecular insights into anammox inhibition induced by environmentally relevant sulfamonomethoxine and functional recovery via voltage stimulation\" [Bioresour. Technol. 436 (2025) 133018].","journal":"Bioresource technology"},{"date":"2025 Dec","pmid":"41246051","title":"TiO₂-modified activated carbon for pharmaceutical contaminant removal: experimental and in-silico insights using density functional theory.","journal":"Journal of environmental health science & engineering"},{"date":"2026 Jan","pmid":"40795590","title":"Piezoelectric-driven self-powered sensor with tunable plasmonic hotspots for enhanced SERS performance.","journal":"Journal of colloid and interface science"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Daimeton is a small molecule with the synonyms Sulfamonomethoxine, NSC-757862, and DAIMETON.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}