{"id":"sulfametrole","rwe":[],"tags":[{"label":"sulfametrole","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01EE03","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["sulfametrole"],"offLabel":[],"synonyms":["sulfametrole"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"sulfametrole","explanation":"Think of it like a key that fits into a lock. Bacteria need a certain enzyme to build their cell walls, and sulfamethrole blocks that enzyme, preventing the bacteria from building their walls and ultimately killing them.","oneSentence":"Sulfamethrole works by inhibiting the enzyme dihydropteroate synthase, which is necessary for bacterial cell wall synthesis.","technicalDetail":"Sulfamethrole acts as a competitive inhibitor of dihydropteroate synthase, an enzyme involved in the synthesis of tetrahydrofolate, a precursor to purines and thymidylate, which are essential for bacterial DNA synthesis and repair."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2518","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SULFAMETROLE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:45:35.535329","biosimilars":[],"competitors":[{"drugName":"sulfamethoxazole","drugSlug":"sulfamethoxazole","fdaApproval":"1973-07-30","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"trimethoprim","drugSlug":"trimethoprim","fdaApproval":"1973-07-30","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sulfadiazine","drugSlug":"sulfadiazine","fdaApproval":"1941-08-11","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sulfadimidine","drugSlug":"sulfadimidine","fdaApproval":"1949-08-16","relationship":"same-class"},{"drugName":"sulfamerazine","drugSlug":"sulfamerazine","fdaApproval":"1949-08-16","relationship":"same-class"}],"genericName":"sulfametrole","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"sulfamethoxazole","brandName":"sulfamethoxazole","genericName":"sulfamethoxazole","approvalYear":"1973","relationship":"same-class"},{"drugId":"trimethoprim","brandName":"trimethoprim","genericName":"trimethoprim","approvalYear":"1973","relationship":"same-class"},{"drugId":"sulfadiazine","brandName":"sulfadiazine","genericName":"sulfadiazine","approvalYear":"1941","relationship":"same-class"},{"drugId":"sulfadimidine","brandName":"sulfadimidine","genericName":"sulfadimidine","approvalYear":"1949","relationship":"same-class"},{"drugId":"sulfamerazine","brandName":"sulfamerazine","genericName":"sulfamerazine","approvalYear":"1949","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005941","UNII":"F5AK41IPQG","CHEBI":"CHEBI:88258","INN_ID":"3526","RXNORM":"37328","UMLSCUI":"C0075512","ChEMBL_ID":"CHEMBL2105398","KEGG_DRUG":"D08541","DRUGBANK_ID":"DB15975","PUBCHEM_CID":"64939","IUPHAR_LIGAND_ID":"12702","MESH_SUPPLEMENTAL_RECORD_UI":"C012047"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":21,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01EE03","allCodes":["J01EE03"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"SULFAMETROLE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sulfamethrole is a small molecule. It is also known by the synonyms Sulfamethrol and Sulfamethrole.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}