{"id":"sulfamerazine","rwe":[],"tags":[{"label":"sulfamerazine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D06BA06","category":"atc"},{"label":"Active","category":"status"},{"label":"Lederle","category":"company"},{"label":"Approved 1940s","category":"decade"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"marketed","safety":{"contraindications":["Anemia due to enzyme deficiency","Breastfeeding (mother)","Disease of blood AND/OR blood-forming organ","Disease of liver","Kidney disease","Megaloblastic anemia due to folate deficiency","Porphyria","Third trimester pregnancy"]},"trials":[],"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"allNames":"sulfamerazin","offLabel":[],"synonyms":["sulfamerazine","sulphamerazine","cremomerazine","methylsulfazine","metilsulfadiazin","sulfamerazin"],"timeline":[{"date":"1949-08-16","type":"positive","source":"DrugCentral","milestone":"FDA approval (Lederle)"}],"aiSummary":"Sulfamerazine is a sulfonamide antibiotic small molecule developed by Lederle, which was FDA approved in 1949. It belongs to the sulfonamide class of drugs but its target is unknown. Sulfamerazine is used to treat various bacterial infections, although its specific indications are not provided. The commercial status of sulfamerazine is unclear, as it is owned by Lederle but its patent status is unknown. Key safety considerations include its bioavailability of 81%, but its half-life and generic manufacturers are unknown.","approvals":[{"date":"1949-08-16","orphan":false,"company":"LEDERLE","regulator":"FDA"}],"brandName":"Sulfamerazin","ecosystem":[],"mechanism":{"target":"Dihydropteroate synthase","novelty":"Follow-on","modality":"Small Molecule","drugClass":"sulfamerazine","explanation":"Imagine your body's cells are like factories that need a special ingredient called folic acid to make more cells. Sulfamerazine blocks the bacteria's ability to make this ingredient, so they can't grow and multiply. This helps your body fight off the infection.","oneSentence":"Sulfamerazine works by inhibiting the synthesis of folic acid in bacteria, which is essential for their growth and replication.","technicalDetail":"Sulfamerazine acts as a competitive inhibitor of dihydropteroate synthase, an enzyme involved in the synthesis of tetrahydrofolate, a crucial precursor for DNA and RNA synthesis in bacteria."},"commercial":{"launchDate":"1949","_launchSource":"DrugCentral (FDA 1949-08-16, LEDERLE)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2510","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SULFAMERAZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:44:47.799746","biosimilars":[],"competitors":[{"drugName":"sulfadiazine 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available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"sulfamerazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"sulfadiazine-silver","brandName":"sulfadiazine silver","genericName":"sulfadiazine 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Developer"}],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"81%"},"publicationCount":0,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"D06BA06","allCodes":["D06BA06","J01ED07","J01EE07"]},"biosimilarFilings":[],"originalDeveloper":"Lederle","recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"withdrawn","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"1949","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":"1949-08-16T00:00:00.000Z","mah":"LEDERLE","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health 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