{"id":"sulfafurazole","rwe":[],"tags":[{"label":"Sulfonamide Antimicrobial","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Endothelin-1 receptor","category":"target"},{"label":"EDNRA","category":"gene"},{"label":"HRH4","category":"gene"},{"label":"EDNRB","category":"gene"},{"label":"J01EB05","category":"atc"},{"label":"Active","category":"status"},{"label":"Acute otitis media","category":"indication"},{"label":"Chancroid","category":"indication"},{"label":"Chlamydia Cervicitis","category":"indication"},{"label":"Chlamydial conjunctivitis","category":"indication"},{"label":"Falciparum malaria","category":"indication"},{"label":"Haemophilus Influenzae Acute Otitis Media","category":"indication"},{"label":"Alra","category":"company"},{"label":"Approved 1970s","category":"decade"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antiparasitic Agents","category":"pharmacology"},{"label":"Antiprotozoal Agents","category":"pharmacology"},{"label":"Coccidiostats","category":"pharmacology"}],"phase":"marketed","safety":{"drugInteractions":[{"url":"/drug/methotrexate","drug":"methotrexate","action":"Avoid combination","effect":"May interact with Methotrexate, Sulfisoxazole","source":"DrugCentral","drugSlug":"methotrexate"},{"url":"/drug/pralatrexate","drug":"pralatrexate","action":"Avoid combination","effect":"May interact with Pralatrexate, Sulfisoxazole","source":"DrugCentral","drugSlug":"pralatrexate"},{"url":"/drug/warfarin","drug":"warfarin","action":"Monitor closely","effect":"May interact with Sulfisoxazole, Warfarin","source":"DrugCentral","drugSlug":"warfarin"}],"contraindications":["Acute hepatitis","Anemia due to enzyme deficiency","Aplastic anemia","Asthma","Cholestatic hepatitis","Congenital long QT syndrome","Deficiency of glucose-6-phosphate dehydrogenase","Disease of blood AND/OR blood-forming organ","Disease of liver","Gastrointestinal obstruction","Glomerulonephritis","Hearing disorder","Kidney disease","Liver function tests abnormal","Megaloblastic anemia due to folate deficiency","Myasthenia gravis","Neutropenic disorder","Porphyria","Prolonged QT interval","Pseudomembranous enterocolitis","Slow acetylator due to N-acetyltransferase enzyme variant","Third trimester pregnancy","Torsades de pointes","Uremia","Urinary tract obstruction"]},"trials":[],"aliases":[],"company":"Alra","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=sulfafurazole","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:39:44.975947+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:39:51.709656+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=sulfafurazole","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:39:52.100974+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Bacterial dihydropteroate synthase inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:39:53.326643+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL453/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:39:52.977273+00:00"}},"allNames":"azo gantrisin","offLabel":[],"synonyms":["sulfafurazole diolamine","sulfisoxazole","alphazole","soxomide","sulfadimethylisoxazole","sulfafurazol","sulfafurazole","sulfaisoxazole","sulfazin","sulfisoxazol","sulfisoxazole dialamine","sulphafurazole","sulfisoxazole diolamine"],"timeline":[{"date":"1971-06-07","type":"positive","source":"DrugCentral","milestone":"FDA approval (Alra)"}],"aiSummary":"Azo Gantrisin, also known as sulfafurazole, is a sulfonamide antimicrobial drug developed by ALRA. It targets the endothelin-1 receptor and is used to treat various bacterial infections, including otitis media, chancroid, and meningococcal meningitis. The drug is a small molecule with a bioavailability of 96% and a half-life of 7.4 hours. It was FDA-approved in 1971 and is currently owned by ALRA. As a sulfonamide antimicrobial, Azo Gantrisin works by inhibiting bacterial growth and replication.","approvals":[{"date":"1971-06-07","orphan":false,"company":"ALRA","regulator":"FDA"}],"brandName":"Azo Gantrisin","ecosystem":[{"indication":"Acute otitis media","otherDrugs":[{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth Ayerst"},{"name":"benzylpenicillin","slug":"benzylpenicillin","company":"Pfizer"},{"name":"cefalexin","slug":"cefalexin","company":"Shionogi Inc"}],"globalPrevalence":709000000},{"indication":"Chancroid","otherDrugs":[{"name":"azithromycin","slug":"azithromycin","company":""},{"name":"ceftriaxone","slug":"ceftriaxone","company":""},{"name":"ciprofloxacin","slug":"ciprofloxacin","company":"Bayer Hlthcare"},{"name":"demeclocycline","slug":"demeclocycline","company":"Lederle"}],"globalPrevalence":null},{"indication":"Chlamydia 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