{"id":"sulfadoxine-pyrimethamine-used-for-ipti","safety":{"commonSideEffects":[{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Folate deficiency"},{"rate":null,"effect":"Stevens-Johnson syndrome (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Sulfadoxine inhibits dihydropteroate synthase, while pyrimethamine inhibits dihydrofolate reductase, both enzymes critical for parasitic folate metabolism. This dual mechanism prevents DNA synthesis in Plasmodium parasites. When used for intermittent preventive treatment in infants (IPTi), it provides prophylactic protection against malaria in high-transmission settings.","oneSentence":"Sulfadoxine-pyrimethamine is a fixed-dose combination of two antifolate drugs that inhibits dihydrofolate reductase and dihydropteroate synthase, blocking folate synthesis in malaria parasites.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:53:44.050Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intermittent preventive treatment of malaria in infants (IPTi)"},{"name":"Malaria treatment and prophylaxis"}]},"trialDetails":[{"nctId":"NCT00152204","phase":"PHASE3","title":"The Community Effectiveness of IPTi in Southern Tanzania","status":"UNKNOWN","sponsor":"Swiss Tropical & Public Health Institute","startDate":"2005-03","conditions":"Malaria, Falciparum, Anemia","enrollment":13000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":68,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Brand of SP used is Fanisdar"],"phase":"phase_3","status":"active","brandName":"Sulfadoxine-pyrimethamine used for IPTi","genericName":"Sulfadoxine-pyrimethamine used for IPTi","companyName":"Swiss Tropical & Public Health Institute","companyId":"swiss-tropical-public-health-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sulfadoxine-pyrimethamine is a fixed-dose combination of two antifolate drugs that inhibits dihydrofolate reductase and dihydropteroate synthase, blocking folate synthesis in malaria parasites. Used for Intermittent preventive treatment of malaria in infants (IPTi), Malaria treatment and prophylaxis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}