{"id":"sulfadoxine-pyrimethamine-sp","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL3137690","moleculeType":"Unknown","molecularWeight":"559.05"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Sulfadoxine is a sulfonamide antibiotic that inhibits dihydropteroate synthase, an enzyme involved in the synthesis of tetrahydrofolic acid. Pyrimethamine is a dihydrofolate reductase inhibitor that also interferes with the synthesis of tetrahydrofolic acid. This dual mechanism of action makes SP effective against a wide range of bacteria.","oneSentence":"Sulfadoxine pyrimethamine (SP) is a combination antibiotic that works by inhibiting the growth of bacteria by interfering with their ability to synthesize folic acid.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:36:42.322Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria prophylaxis and treatment"}]},"trialDetails":[{"nctId":"NCT05085340","phase":"","title":"MULTIple Doses of IPTi Proposal: a Lifesaving High Yield Intervention","status":"COMPLETED","sponsor":"Barcelona Institute for Global Health","startDate":"2022-02-14","conditions":"Malaria","enrollment":94252},{"nctId":"NCT07322068","phase":"PHASE4","title":"Perennial Malaria Chemoprevention in the Malaria Vaccine Era","status":"NOT_YET_RECRUITING","sponsor":"Stanford University","startDate":"2026-09","conditions":"Malaria, Falciparum","enrollment":1290},{"nctId":"NCT06083688","phase":"PHASE4","title":"Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi","status":"ACTIVE_NOT_RECRUITING","sponsor":"Liverpool School of Tropical Medicine","startDate":"2024-10-14","conditions":"Malaria,Falciparum, Anemia in Children","enrollment":1000},{"nctId":"NCT04336189","phase":"PHASE3","title":"Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda","status":"COMPLETED","sponsor":"Grant Dorsey, M.D, Ph.D.","startDate":"2020-12-28","conditions":"Malaria","enrollment":2757},{"nctId":"NCT05426434","phase":"PHASE3","title":"Sulfadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine for Intermittent Preventive Treatment in Pregnancy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Menzies School of Health Research","startDate":"2022-08-31","conditions":"Malaria, Malaria in Pregnancy, Pregnancy Related","enrollment":1172},{"nctId":"NCT00131235","phase":"PHASE3","title":"Gestational Sulfadoxine-pyrimethamine and Azithromycin Treatment to Prevent Preterm Birth","status":"ACTIVE_NOT_RECRUITING","sponsor":"Tampere University","startDate":"2003-12","conditions":"Malaria, Sexually Transmitted Diseases, Preterm Birth","enrollment":1320},{"nctId":"NCT06173206","phase":"PHASE3","title":"Parasite Clearance and Protection from Infection (PCPI) in Cameroon","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-06-10","conditions":"Malaria","enrollment":902},{"nctId":"NCT06166498","phase":"PHASE3","title":"Parasite Clearance and Protection From Infection (PCPI) in Zambia","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-07-24","conditions":"Malaria","enrollment":600},{"nctId":"NCT00131703","phase":"PHASE3","title":"Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian Pregnant Women","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2003-03","conditions":"Malaria, Pregnancy","enrollment":900},{"nctId":"NCT06225297","phase":"PHASE4","title":"Evaluation of Vector and Chemoprevention-based Interventions to Reduce Malaria Burden in Urban Daaras of Touba, Senegal","status":"SUSPENDED","sponsor":"PATH","startDate":"2024-01-19","conditions":"Malaria","enrollment":4600},{"nctId":"NCT06002438","phase":"NA","title":"Eggs for Gut Health","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2023-10-09","conditions":"Moderate Acute Malnutrition, Stunting, Environmental Enteric Dysfunction","enrollment":461},{"nctId":"NCT05889052","phase":"","title":"Perennial Malaria Chemoprevention (PMC) in Cameroon","status":"ACTIVE_NOT_RECRUITING","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2023-07-19","conditions":"Anemia, Malaria","enrollment":2080},{"nctId":"NCT05856357","phase":"","title":"Perennial Malaria Chemoprevention (PMC) in Côte D'Ivoire","status":"ACTIVE_NOT_RECRUITING","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2023-08-11","conditions":"Malaria, Anemia","enrollment":1568},{"nctId":"NCT02163447","phase":"PHASE3","title":"Reducing the Burden of Malaria in HIV-uninfected Pregnant Women and Infants","status":"COMPLETED","sponsor":"Grant Dorsey, M.D, Ph.D.","startDate":"2014-06-23","conditions":"Malaria","enrollment":300},{"nctId":"NCT05571280","phase":"NA","title":"Community-based, Controlled, Open-label, Cluster-randomized Trial for the Reduction of Chronic Malnutrition in Children Under Two Years of Age, With Three Intervention Arms Grouped by Clusters, in Two Provinces in Southern Angola, Huíla and Cunene.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hospital Universitari Vall d'Hebron Research Institute","startDate":"2022-10-10","conditions":"Malnutrition, Child","enrollment":1423},{"nctId":"NCT04319380","phase":"PHASE3","title":"Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension Study","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2020-04-01","conditions":"Malaria,Falciparum, Child, Only","enrollment":5098},{"nctId":"NCT04280692","phase":"PHASE1, PHASE2","title":"Controlled Human Malaria Infection Transmission Model - Phase A","status":"SUSPENDED","sponsor":"University of Oxford","startDate":"2022-08-22","conditions":"Malaria,Falciparum","enrollment":44},{"nctId":"NCT03178643","phase":"PHASE4","title":"Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)","status":"COMPLETED","sponsor":"Duke University","startDate":"2018-01-23","conditions":"Malaria,Falciparum","enrollment":246},{"nctId":"NCT06337253","phase":"PHASE4","title":"Seasonal Malaria Chemoprevention Rapid Assessment Study Mozambique","status":"NOT_YET_RECRUITING","sponsor":"Malaria Consortium","startDate":"2024-03-26","conditions":"Malaria,Falciparum, Chemoprevention","enrollment":1000},{"nctId":"NCT05471544","phase":"PHASE3","title":"Effectiveness, Feasibility and Acceptability of Seasonal Malaria Chemoprevention in Aweil South County in South Sudan","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-07-18","conditions":"Malaria","enrollment":3575},{"nctId":"NCT00852371","phase":"PHASE3","title":"Intermittent Preventive Treatment of Malaria in Schoolchildren","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2008-02","conditions":"Malaria, Intermittent Preventive Treatment","enrollment":780},{"nctId":"NCT06182176","phase":"NA","title":"Effectiveness and Cost-effectiveness of Integrated Model for Malaria and Helminth Control","status":"UNKNOWN","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-05-27","conditions":"Malaria, Soil Transmitted Helminths, Schistosomiasis","enrollment":1200},{"nctId":"NCT05946642","phase":"PHASE3","title":"Innovative Intermittent Preventive Treatment Approaches to Reduce Malaria Burden in School-age Children in Burkina Faso","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2023-07-15","conditions":"Malaria","enrollment":13000},{"nctId":"NCT05186363","phase":"PHASE4","title":"Effectiveness of Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Type Two Hybrid Implementation Study","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-01-08","conditions":"Malaria","enrollment":3156},{"nctId":"NCT05323721","phase":"PHASE4","title":"Effectiveness and Chemoprevention Efficacy of Implementing Seasonal Malaria Chemoprevention in Karamoja Region, Uganda","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-06-01","conditions":"Malaria","enrollment":6805},{"nctId":"NCT05478954","phase":"PHASE4","title":"Chemoprevention Efficacy Study in Burkina Faso","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-07-15","conditions":"Malaria","enrollment":800},{"nctId":"NCT04844099","phase":"PHASE3","title":"Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Sickle Cell Anaemia","status":"COMPLETED","sponsor":"Liverpool School of Tropical Medicine","startDate":"2021-04-09","conditions":"Sickle Cell Anemia in Children, Malaria","enrollment":723},{"nctId":"NCT04969185","phase":"","title":"Association Between Drug Levels, Malaria, and Antimalarial Resistance in the Setting of Seasonal Malaria Chemoprevention","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2021-08-16","conditions":"Malaria,Falciparum","enrollment":310},{"nctId":"NCT05980156","phase":"PHASE4","title":"Comparing Chemoprevention Drugs for School-based Malaria Control","status":"COMPLETED","sponsor":"University of Maryland, Baltimore","startDate":"2023-02-13","conditions":"Malaria,Falciparum, Anemia in Children","enrollment":646},{"nctId":"NCT03998839","phase":"","title":"TIPTOP Sulfadoxine-pyrimethamine (SP) Drug Resistance Study","status":"COMPLETED","sponsor":"Jhpiego","startDate":"2018-03-05","conditions":"Malaria in Pregnancy","enrollment":7200},{"nctId":"NCT04189744","phase":"PHASE3","title":"The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2019-12-15","conditions":"Pregnancy Malaria, Bacterial Vaginoses, Trichomonas Vaginitis","enrollment":5436},{"nctId":"NCT04783051","phase":"PHASE3","title":"Comparison of ISTp- PYRAMAX-US-RDT to IPTp-SP to Prevent Malaria in Pregnant Women in DRC (ULTRAPYRAPREG)","status":"COMPLETED","sponsor":"University of Kinshasa","startDate":"2021-05-06","conditions":"Malaria in Pregnancy","enrollment":250},{"nctId":"NCT03208179","phase":"PHASE3","title":"Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa","status":"COMPLETED","sponsor":"Liverpool School of Tropical Medicine","startDate":"2018-03-29","conditions":"Pregnancy, Malaria in Pregnancy, Malaria","enrollment":4680},{"nctId":"NCT03143218","phase":"PHASE3","title":"Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ)","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2017-04-17","conditions":"Malaria,Falciparum, Children, Only","enrollment":5920},{"nctId":"NCT02557425","phase":"","title":"Prophylaxis Against Malaria to Enhance Child Development (PROTECT Study)","status":"COMPLETED","sponsor":"Indiana University","startDate":"2015-10","conditions":"Neurobehavioral Manifestations","enrollment":272},{"nctId":"NCT03376217","phase":"NA","title":"Assessing the Effectiveness of Community Delivery of Intermittent Preventive Treatment in Pregnancy (IPTp) in Malawi","status":"COMPLETED","sponsor":"Kamuzu University of Health Sciences","startDate":"2017-12-01","conditions":"Malaria in Pregnancy","enrollment":1447},{"nctId":"NCT03009526","phase":"PHASE3","title":"Efficacy and Safety of IPTp-DP Versus IPTp-SP in Malawi","status":"COMPLETED","sponsor":"Kamuzu University of Health Sciences","startDate":"2017-01-17","conditions":"Malaria, Pregnancy","enrollment":602},{"nctId":"NCT04160026","phase":"PHASE4","title":"Acceptability and Feasibility in the Context of the IMPROVE Trial in Kenya","status":"COMPLETED","sponsor":"Liverpool School of Tropical Medicine","startDate":"2019-11-11","conditions":"Malaria in Pregnancy, Adherence, Treatment","enrollment":1600},{"nctId":"NCT02793622","phase":"PHASE3","title":"Prevention of Malaria in HIV-uninfected Pregnant Women and Infants","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2016-09","conditions":"Malaria","enrollment":782},{"nctId":"NCT02909712","phase":"PHASE2","title":"Cardiac Safety of Dihydroartemisinin-Piperaquine Amongst Pregnant Women in Tanzania","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2016-09","conditions":"Malaria, Pregnancy Malaria, Cardiotoxicity","enrollment":201},{"nctId":"NCT01746199","phase":"PHASE3","title":"Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum","status":"COMPLETED","sponsor":"Institut Pasteur","startDate":"2013-12","conditions":"Malaria in Pregnancy, HIV Infection","enrollment":193},{"nctId":"NCT04634695","phase":"","title":"Assessing to What Extent Dhps-431V Mutation May Influence the Protective Efficacy of IPTp-SP","status":"UNKNOWN","sponsor":"Obafemi Awolowo University","startDate":"2020-08-10","conditions":"Pregnancy Malaria","enrollment":288},{"nctId":"NCT01707199","phase":"NA","title":"SPK Study in Afghanistan","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2012-10","conditions":"Uncomplicated P. Falciparum Malaria","enrollment":83},{"nctId":"NCT03454048","phase":"NA","title":"Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2","status":"COMPLETED","sponsor":"Radboud University Medical Center","startDate":"2018-05-07","conditions":"Malaria,Falciparum, Gametocytes, Controlled Human Malaria Infection","enrollment":24},{"nctId":"NCT03944317","phase":"NA","title":"Azithromycin (AZ) and Sulphadoxine-pyrimethamine (SP) for Malaria Prevention in Pregnant Women (IPT-AZ/IPT-SP)","status":"UNKNOWN","sponsor":"Federal Medical Centre, Owo","startDate":"2019-06-01","conditions":"Malaria in Pregnancy, Pregnancy","enrollment":168},{"nctId":"NCT00299247","phase":"PHASE3","title":"SP Resistance and Falciparum Malaria Transmission","status":"WITHDRAWN","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"Plasmodium Falciparum Malaria","enrollment":""},{"nctId":"NCT02836002","phase":"PHASE1, PHASE2","title":"Controlled Human Malaria Infection Model for Evaluation of Transmission-Blocking Interventions - Study 1","status":"COMPLETED","sponsor":"Radboud University Medical Center","startDate":"2016-06","conditions":"Malaria","enrollment":29},{"nctId":"NCT01669941","phase":"PHASE4","title":"Efficacy of Intermittent Screening and Treatment or Intermittent Preventive Treatment (IPT) With Dihydroartemisinin-Piperaquine, Versus IPT With Sulfadoxine-Pyrimethamine for the Control of Malaria in Pregnancy in Kenya","status":"COMPLETED","sponsor":"Kenya Medical Research Institute","startDate":"2012-08","conditions":"Pregnancy, Malaria","enrollment":1546},{"nctId":"NCT00361114","phase":"PHASE3","title":"IPT and Efficacy of Sulphadoxine/Pyrimethamine and Chlorproguanil/Dapsone in 6-59 Month Old Children With Malaria.","status":"TERMINATED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2006-07","conditions":"Malaria","enrollment":112},{"nctId":"NCT00561899","phase":"PHASE2, PHASE3","title":"Comparison of Three Drug Combinations for Intermittent Treatment of Malaria in Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2007-08","conditions":"Malaria","enrollment":1295},{"nctId":"NCT00944840","phase":"PHASE3","title":"Intermittent Preventive Treatment (IPTc) and Home Based Management of Malaria (HMM)in The Gambia","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2008-09","conditions":"Malaria","enrollment":1312},{"nctId":"NCT00857077","phase":"NA","title":"Intermittent Preventive Treatment for Malaria in Infants in Navrongo Ghana","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2000-09","conditions":"Anaemia, Malaria","enrollment":2485},{"nctId":"NCT00494416","phase":"NA","title":"Different Approaches for Delivery of IPT in Pregnancy in Burkina Faso","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2007-06","conditions":"Malaria Parasitaemia, Birth Weight, Anaemia","enrollment":11523},{"nctId":"NCT00158574","phase":"PHASE2, PHASE3","title":"Kilimanjaro IPTi Drug Options Trial","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2005-01","conditions":"Malaria","enrollment":2419},{"nctId":"NCT00132561","phase":"PHASE2, PHASE3","title":"A Trial of Intermittent Treatment in the Prevention of Malaria in Senegalese Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2002-06","conditions":"Malaria","enrollment":1200},{"nctId":"NCT00158561","phase":"PHASE3","title":"Chlorproguanil/Dapsone Compared With Chloroquine and SP for Vivax Malaria","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2004-02","conditions":"Malaria, Vivax Malaria","enrollment":750},{"nctId":"NCT00158548","phase":"PHASE3","title":"ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistan","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2001-06","conditions":"Malaria, Falciparum Malaria, Vivax Malaria","enrollment":650},{"nctId":"NCT02831023","phase":"PHASE2","title":"Phase 2 Efficacy Study of Primaquine and Methylene Blue","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2016-07","conditions":"Malaria","enrollment":80},{"nctId":"NCT01443130","phase":"PHASE3","title":"Chloroquine for Malaria in Pregnancy","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2012-02","conditions":"Malaria","enrollment":900},{"nctId":"NCT00380146","phase":"NA","title":"Pharmacokinetics, Efficacy, Gametocyte Carriage, Birth Outcomes Following Sulfadoxine-pyrimethamine Intermittent Presumptive Treatment in Pregnant Women","status":"COMPLETED","sponsor":"Professor Karen I Barnes","startDate":"2006-09","conditions":"Malaria","enrollment":31},{"nctId":"NCT00432367","phase":"PHASE3","title":"Intermittent Preventive Treatment (IPTp) Versus Rapid Diagnostic Testing (RDT) and Treatment of Malaria in Pregnancy","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2007-02","conditions":"Malaria, Anaemia, Pregnancy","enrollment":3333},{"nctId":"NCT02894294","phase":"","title":"Evaluation of Seasonal Malaria Chemoprevention in Kita","status":"COMPLETED","sponsor":"University of Bamako","startDate":"2014-07","conditions":"Malaria, Anemia","enrollment":1162},{"nctId":"NCT02758353","phase":"NA","title":"The Impact of Sulphadoxine-Pyrimethamine Use At Scale on Newborn Outcomes in Nigeria","status":"COMPLETED","sponsor":"JSI Research & Training Institute, Inc.","startDate":"2015-04","conditions":"Malaria, Stillbirths","enrollment":31493},{"nctId":"NCT00711906","phase":"PHASE3","title":"Daily Co-trimoxazole Prophylaxis to Prevent Malaria in Pregnancy","status":"TERMINATED","sponsor":"Institute of Tropical Medicine, Belgium","startDate":"2009-02","conditions":"Malaria in Pregnancy","enrollment":352},{"nctId":"NCT00948896","phase":"PHASE3","title":"Chemopreventive Therapy for Malaria in Ugandan Children","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2010-06","conditions":"Malaria","enrollment":600},{"nctId":"NCT01103063","phase":"PHASE3","title":"Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa","status":"TERMINATED","sponsor":"Pfizer","startDate":"2010-10","conditions":"Intermittent Preventive Treatment In Pregnancy (IPTp)","enrollment":2891},{"nctId":"NCT01184911","phase":"PHASE4","title":"Sulphadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda","status":"WITHDRAWN","sponsor":"University of California, San Francisco","startDate":"2010-10","conditions":"Intermittent Preventive Treatment, Placental Malaria","enrollment":""},{"nctId":"NCT01084213","phase":"PHASE4","title":"Intermittent Preventive Treatment Versus Scheduled Screening and Treatment of Malaria in Pregnancy","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2010-06","conditions":"Malaria, Pregnancy, Anaemia","enrollment":5354},{"nctId":"NCT01319448","phase":"PHASE1, PHASE2","title":"Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2011-09","conditions":"Malaria, Sickle Cell Crisis","enrollment":270},{"nctId":"NCT00811421","phase":"NA","title":"Evaluation of Alternative Antimalarial Drugs for Malaria in Pregnancy","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2009-09","conditions":"Pregnancy, Malaria, HIV Infections","enrollment":5820},{"nctId":"NCT01053325","phase":"PHASE3","title":"Establishing Effectiveness of Daily Co-trimoxazole Prophylaxis For Prevention of Malaria in Pregnancy","status":"COMPLETED","sponsor":"Institute of Tropical Medicine, Belgium","startDate":"2010-09","conditions":"Malaria in Pregnancy, HIV Infections","enrollment":848},{"nctId":"NCT01634945","phase":"NA","title":"Efficacy of Iron Fortified Complementary Food and IPT of Malaria in Young Children in Côte d'Ivoire","status":"COMPLETED","sponsor":"Swiss Federal Institute of Technology","startDate":"2012-04","conditions":"Anemia","enrollment":629},{"nctId":"NCT01136850","phase":"PHASE3","title":"Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea","status":"COMPLETED","sponsor":"University of Melbourne","startDate":"2009-11","conditions":"Malaria in Pregnancy, Sexually Transmitted Infections, Anaemia","enrollment":2793},{"nctId":"NCT01120145","phase":"","title":"Assessment of Sulphadoxine-pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Malawi","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2010-03","conditions":"Malaria in Pregnancy","enrollment":1410},{"nctId":"NCT00164710","phase":"PHASE4","title":"Assessing the Efficacy of Four Drug Combinations as the Next First-line Therapy for Uncomplicated Malaria in Malawi","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2005-04","conditions":"Malaria, Falciparum","enrollment":365},{"nctId":"NCT00140361","phase":"PHASE4","title":"Efficacy of Sulphadoxine-pyrimethamine and Artemisinin-containing Combination Therapy for Malaria","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2000-01","conditions":"Malaria (Uncomplicated)","enrollment":390},{"nctId":"NCT01636895","phase":"PHASE4","title":"Evaluation of SP Resistance and Effectiveness of IPTp in Nigeria","status":"UNKNOWN","sponsor":"Malaria Consortium, UK","startDate":"2011-01","conditions":"Pregnancy Complications Parasitic","enrollment":600},{"nctId":"NCT01115439","phase":"","title":"Artesunate+Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Falciparum Malaria","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2010-03","conditions":"Falciparum Malaria","enrollment":100},{"nctId":"NCT01255605","phase":"","title":"Impact of IPT With Sulfadoxin Pyrimetamin on Pregnant Women and Their Babies Outcomes in Peri-urban Areas of Bobo-Dioulasso(Burkina Faso)","status":"COMPLETED","sponsor":"Université Polytechnique de Bobo-Dioulasso","startDate":"2010-09","conditions":"Malaria, Pregnancy","enrollment":772},{"nctId":"NCT00231452","phase":"NA","title":"Age of Exposure and Immunity to Malaria in Infants","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2005-09","conditions":"Malaria","enrollment":349},{"nctId":"NCT00285662","phase":"NA","title":"Intermittent Preventive Treatment (IPTi) for the Prevention of Malaria and Anaemia in PNG Infants","status":"COMPLETED","sponsor":"Papua New Guinea Institute of Medical Research","startDate":"2006-06","conditions":"Malaria, Anemia","enrollment":1100},{"nctId":"NCT00941785","phase":"PHASE2, PHASE3","title":"Dihydroartemisinin (DHA)-Piperaquine for IPT to Prevent Malaria in Children in Burkina Faso","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2009-07","conditions":"Malaria","enrollment":1500},{"nctId":"NCT00680732","phase":"PHASE4","title":"Prevention of Intrauterine Growth Retardation in Burkina Faso: the Malaria Component","status":"COMPLETED","sponsor":"Institute of Tropical Medicine, Belgium","startDate":"2003-06","conditions":"Malaria, Malaria in Pregnancy","enrollment":1370},{"nctId":"NCT00304980","phase":"NA","title":"Comparative Evaluation of the Safety and the Efficacy of 2 Antimalarials Depending on HIV Status","status":"TERMINATED","sponsor":"Institute of Tropical Medicine, Belgium","startDate":"2003-03","conditions":"Plasmodium Falciparum Malaria","enrollment":3000},{"nctId":"NCT00730366","phase":"PHASE3","title":"New Approaches to Improve Coverage and Compliance of Antimalarial Treatment for Pregnant Women in Rural Africa","status":"COMPLETED","sponsor":"Institute of Tropical Medicine, Belgium","startDate":"2004-03","conditions":"Malaria in Pregnancy","enrollment":2766},{"nctId":"NCT00372632","phase":"PHASE4","title":"IPT of Malaria With SP in Different Zones of Drug Resistance in Rwanda","status":"COMPLETED","sponsor":"Institute of Tropical Medicine, Belgium","startDate":"2005-12","conditions":"Non HIV Infected Pregnant Women","enrollment":1717},{"nctId":"NCT00964691","phase":"PHASE4","title":"A Randomized Controlled Trial for Intermittent Preventive Treatment in Pregnancy With Fansidar in Solomon Islands","status":"TERMINATED","sponsor":"Ministry of Health and Medical Services, Solomon Islands","startDate":"2009-08","conditions":"Malaria, Malaria in Pregnancy","enrollment":2504},{"nctId":"NCT00738946","phase":"NA","title":"A Trial of the Combined Impact of Intermittent Preventive Treatment and Insecticide Treated Bednets in Reducing Morbidity From Malaria in African Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2008-08","conditions":"Malaria","enrollment":6000},{"nctId":"NCT00452907","phase":"PHASE4","title":"ACT MALI: Treatment of Malaria Based on Combination Therapies","status":"COMPLETED","sponsor":"Sanofi","startDate":"2005-07","conditions":"Malaria","enrollment":780},{"nctId":"NCT00712374","phase":"PHASE4","title":"Evaluation of the Public Health Impact of Seasonal Intermittent Preventive Treatment (IPT) in Children in Senegal","status":"UNKNOWN","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2008-09","conditions":"Malaria","enrollment":100000},{"nctId":"NCT00959517","phase":"PHASE2","title":"Trial of Artesunate Combination Therapy in Pakistan","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2001-07","conditions":"Uncomplicated Falciparum Malaria","enrollment":588},{"nctId":"NCT00399074","phase":"PHASE3","title":"Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia","status":"COMPLETED","sponsor":"Makerere University","startDate":"2006-10","conditions":"Sickle Cell Anemia, Malaria","enrollment":220},{"nctId":"NCT00152204","phase":"PHASE3","title":"The Community Effectiveness of IPTi in Southern Tanzania","status":"UNKNOWN","sponsor":"Swiss Tropical & Public Health Institute","startDate":"2005-03","conditions":"Malaria, Falciparum, Anemia","enrollment":13000},{"nctId":"NCT00646126","phase":"PHASE3","title":"Antimalarial Treatments for Clearing Low Density P. Falciparum and Its Impact on Malaria Transmission","status":"COMPLETED","sponsor":"Tropical Medicine Research Institute","startDate":"2005-08","conditions":"Plasmodium Falciparum, Asymptomatic Parataemia, Sub Patent Parasitaemia","enrollment":""},{"nctId":"NCT00330902","phase":"PHASE3","title":"Randomized Trial of Two Antimalarial Treatments for Clearing Low Density P.Falciparum Parasitaemia in Sudan","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2004-01","conditions":"Plasmodium Infections","enrollment":104},{"nctId":"NCT00461578","phase":"NA","title":"Tolerability and Efficacy of CD+A Compared to AQ+SP for the Treatment of P.Falciparum Malaria in Rwandan Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2005-04","conditions":"Malaria","enrollment":800},{"nctId":"NCT00203814","phase":"NA","title":"A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria","status":"COMPLETED","sponsor":"University of Cape Town","startDate":"2004-01","conditions":"Malaria","enrollment":280},{"nctId":"NCT00203736","phase":"NA","title":"A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria","status":"COMPLETED","sponsor":"University of Cape Town","startDate":"2003-01","conditions":"Malaria","enrollment":240},{"nctId":"NCT00118807","phase":"PHASE3","title":"Trial of the Effectiveness of AQ/AS, SP/AQ and SP/CQ for Uncomplicated Malaria in Gambian Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2003-08","conditions":"Malaria","enrollment":1800},{"nctId":"NCT00168948","phase":"PHASE4","title":"Intermittent Antimalaria Treatment With SP in African Children","status":"UNKNOWN","sponsor":"Charite University, Berlin, Germany","startDate":"2003-03","conditions":"Malaria, Anemia","enrollment":1200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":691,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["G-COSPE"],"phase":"phase_3","status":"active","brandName":"Sulfadoxine pyrimethamine (SP)","genericName":"Sulfadoxine pyrimethamine (SP)","companyName":"Menzies School of Health Research","companyId":"menzies-school-of-health-research","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sulfadoxine pyrimethamine (SP) is a combination antibiotic that works by inhibiting the growth of bacteria by interfering with their ability to synthesize folic acid. Used for Malaria prophylaxis and treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}