{"id":"sulfadoxine-pyrimethamine-plus-artesunate","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Stevens-Johnson syndrome (rare)"}]},"_chembl":{"chemblId":"CHEMBL3137690","moleculeType":"Unknown","molecularWeight":"559.05"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sulfadoxine-pyrimethamine is a fixed-dose antifolate combination that blocks dihydrofolate reductase and dihydropteroate synthase in Plasmodium parasites, preventing nucleotide synthesis. Artesunate is an artemisinin derivative that generates reactive oxygen species and damages parasite mitochondria. Together, they provide rapid parasite clearance and reduce transmission.","oneSentence":"This combination drug kills malaria parasites by inhibiting their folate metabolism (sulfadoxine-pyrimethamine) and disrupting their mitochondrial function (artesunate).","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:10:04.849Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated Plasmodium falciparum malaria"},{"name":"Malaria treatment in endemic regions"}]},"trialDetails":[{"nctId":"NCT06173206","phase":"PHASE3","title":"Parasite Clearance and Protection from Infection (PCPI) in Cameroon","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-06-10","conditions":"Malaria","enrollment":902},{"nctId":"NCT06166498","phase":"PHASE3","title":"Parasite Clearance and Protection From Infection (PCPI) in Zambia","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-07-24","conditions":"Malaria","enrollment":600},{"nctId":"NCT04783051","phase":"PHASE3","title":"Comparison of ISTp- PYRAMAX-US-RDT to IPTp-SP to Prevent Malaria in Pregnant Women in DRC (ULTRAPYRAPREG)","status":"COMPLETED","sponsor":"University of Kinshasa","startDate":"2021-05-06","conditions":"Malaria in Pregnancy","enrollment":250},{"nctId":"NCT03083847","phase":"PHASE1","title":"Dose Escalation PfSPZ-CVac","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2017-06-05","conditions":"Malaria","enrollment":55},{"nctId":"NCT01707199","phase":"NA","title":"SPK Study in Afghanistan","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2012-10","conditions":"Uncomplicated P. 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