{"id":"sulbutiamine","rwe":[{"pmid":"40756350","year":"2025","title":"Multi-dimensional data-driven computational drug repurposing strategy for screening novel neuroprotective agents in ischemic stroke.","finding":"","journal":"Theranostics","studyType":"Clinical Study"},{"pmid":"39302148","year":"2025","title":"Thiamine disulfide derivatives in thiol redox regulation: Role of thioredoxin and glutathione systems.","finding":"","journal":"BioFactors (Oxford, England)","studyType":"Clinical Study"},{"pmid":"39218016","year":"2024","title":"Pharmacological Doses of Thiamine Benefit Patients with the Charcot-Marie-Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes.","finding":"","journal":"Biochemistry. Biokhimiia","studyType":"Clinical Study"},{"pmid":"38344831","year":"2024","title":"Ameliorating diabetes-induced testicular dysfunction by modulating PKC/Nrf2/Bcl-2 signaling: Protective role of sulbutiamine.","finding":"","journal":"BioFactors (Oxford, England)","studyType":"Clinical Study"},{"pmid":"37224990","year":"2023","title":"Regulation of PKC/TLR-4/NF-kB signaling by sulbutiamine improves diabetic nephropathy in rats.","finding":"","journal":"Chemico-biological interactions","studyType":"Clinical Study"}],"tags":[{"label":"sulbutiamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A11DA02","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"youvitan","offLabel":[],"synonyms":["sulbutiamin","sulbuthiamine","youvitan","sulbutiamine","vitaberin","bisibutiamine"],"timeline":[],"approvals":[],"brandName":"Youvitan","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"sulbutiamine","explanation":"Think of Sulbutiamine like a special delivery of vitamin B1 to your brain. It helps your brain cells work more efficiently, which can help to reduce fatigue and improve focus. This can be especially helpful for people with conditions like multiple sclerosis or chronic fatigue syndrome.","oneSentence":"Sulbutiamine works by crossing the blood-brain barrier and increasing the concentration of thiamine in the brain, where it can help to alleviate fatigue and improve cognitive function.","technicalDetail":"Sulbutiamine is a lipophilic derivative of thiamine, which allows it to easily cross the blood-brain barrier and increase thiamine levels in the brain. This increase in thiamine levels is thought to enhance neurotransmitter function and improve energy metabolism in the brain."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2494","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=SULBUTIAMINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SULBUTIAMINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:43:29.587270","biosimilars":[],"competitors":[{"drugName":"thiamine","drugSlug":"thiamine","fdaApproval":"1993-12-29","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"sulbutiamine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"thiamine","brandName":"thiamine","genericName":"thiamine","approvalYear":"1993","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT06497647","phase":"NA","title":"New Treatment for Nocturnal Enuresis in Children","status":"RECRUITING","sponsor":"Sohag University","startDate":"2024-03-01","conditions":["Nocturnal Enuresis in Children"],"enrollment":450,"completionDate":"2024-11"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000189534","NDDF":"005898","UNII":"42NCM1BW43","VUID":"4032901","CHEBI":"CHEBI:31290","VANDF":"4032901","INN_ID":"4827","RXNORM":"37317","UMLSCUI":"C0075501","ChEMBL_ID":"CHEMBL2105813","KEGG_DRUG":"D01319","DRUGBANK_ID":"DB13416","PUBCHEM_CID":"3002120","SNOMEDCT_US":"699182008","MESH_SUPPLEMENTAL_RECORD_UI":"C031331"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":35,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"A11DA02","allCodes":["A11DA02"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025","pmid":"40756350","title":"Multi-dimensional data-driven computational drug repurposing strategy for screening novel neuroprotective agents in ischemic stroke.","journal":"Theranostics"},{"date":"2025 Jan-Feb","pmid":"39302148","title":"Thiamine disulfide derivatives in thiol redox regulation: Role of thioredoxin and glutathione systems.","journal":"BioFactors (Oxford, England)"},{"date":"2024 Jul","pmid":"39218016","title":"Pharmacological Doses of Thiamine Benefit Patients with the Charcot-Marie-Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes.","journal":"Biochemistry. Biokhimiia"},{"date":"2024 Jul-Aug","pmid":"38344831","title":"Ameliorating diabetes-induced testicular dysfunction by modulating PKC/Nrf2/Bcl-2 signaling: Protective role of sulbutiamine.","journal":"BioFactors (Oxford, England)"},{"date":"2023 Aug 25","pmid":"37224990","title":"Regulation of PKC/TLR-4/NF-kB signaling by sulbutiamine improves diabetic nephropathy in rats.","journal":"Chemico-biological interactions"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Youvitan is a small molecule with the chemical name thiamine disulfide O,O-diisobutyrate, also known as sulbutiamine. It is a synthetic derivative of thiamine, a B vitamin.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}