{"id":"sugammadex-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient increase in heart rate"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Recurrence of neuromuscular blockade"}]},"_chembl":{"chemblId":"CHEMBL2111107","moleculeType":"Oligosaccharide","molecularWeight":"2002.18"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sugammadex works by forming a tight 1:1 complex with steroidal neuromuscular blocking drugs (rocuronium, vecuronium, pancuronium) through host-guest chemistry, effectively removing them from the neuromuscular junction and plasma. This allows acetylcholine to restore normal neuromuscular transmission without requiring acetylcholinesterase inhibitors. The drug enables rapid and complete reversal of neuromuscular blockade induced during anesthesia.","oneSentence":"Sugammadex is a selective relaxant binding agent that encapsulates and inactivates steroidal neuromuscular blocking agents, rapidly reversing neuromuscular blockade.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:09:57.742Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reversal of neuromuscular blockade induced by rocuronium or vecuronium in adults undergoing surgery"},{"name":"Reversal of deep neuromuscular blockade in anesthetized patients"}]},"trialDetails":[{"nctId":"NCT06035757","phase":"PHASE4","title":"The Occurrence of Emergence Agitation in Pediatric Strabismus Surgery","status":"RECRUITING","sponsor":"Konkuk University Medical Center","startDate":"2023-12-01","conditions":"Emergence Delirium, Strabismus, Pediatric ALL","enrollment":76},{"nctId":"NCT06112353","phase":"PHASE4","title":"Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection","status":"RECRUITING","sponsor":"University of California, Irvine","startDate":"2024-04-17","conditions":"Intestinal Disease","enrollment":128},{"nctId":"NCT06398899","phase":"NA","title":"Sugammadex v.s. 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Used for Reversal of neuromuscular blockade induced by rocuronium or vecuronium in adults undergoing surgery, Reversal of deep neuromuscular blockade in anesthetized patients.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}