{"id":"sugammadex-ed90","safety":{"commonSideEffects":[{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Recurarization"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sugammadex works by forming a tight 1:1 complex with steroidal neuromuscular blocking agents (rocuronium and vecuronium), removing them from the neuromuscular junction and preventing their interaction with nicotinic acetylcholine receptors. This mechanism allows rapid reversal of neuromuscular blockade without the need for acetylcholinesterase inhibitors. The ED90 designation refers to the dose required to reverse 90% of neuromuscular blockade.","oneSentence":"Sugammadex is a selective relaxant binding agent that encapsulates and inactivates rocuronium and vecuronium neuromuscular blocking agents, rapidly reversing neuromuscular blockade.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:10:07.853Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reversal of neuromuscular blockade induced by rocuronium or vecuronium in adults undergoing surgery"}]},"trialDetails":[{"nctId":"NCT02568345","phase":"PHASE4","title":"Sugammadex ED90 Dose in the Obese Patients","status":"COMPLETED","sponsor":"Faculdade de Ciências Médicas da Santa Casa de São Paulo","startDate":"2013-01","conditions":"Incomplete Reversal of Neuromuscular Block","enrollment":31}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ED90"],"phase":"marketed","status":"active","brandName":"sugammadex ED90","genericName":"sugammadex ED90","companyName":"Faculdade de Ciências Médicas da Santa Casa de São Paulo","companyId":"faculdade-de-ci-ncias-m-dicas-da-santa-casa-de-s-o-paulo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sugammadex is a selective relaxant binding agent that encapsulates and inactivates rocuronium and vecuronium neuromuscular blocking agents, rapidly reversing neuromuscular blockade. Used for Reversal of neuromuscular blockade induced by rocuronium or vecuronium in adults undergoing surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}