{"id":"sufentanil-lidoca-ne","safety":{"commonSideEffects":[{"rate":"null","effect":"Respiratory depression"},{"rate":"null","effect":"Nausea and vomiting"},{"rate":"null","effect":"Hypotension"}]},"_chembl":{"chemblId":"CHEMBL1201163","moleculeType":"Small molecule","molecularWeight":"578.68"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Sufentanil's mechanism of action involves binding to the mu-opioid receptor, which activates G-protein coupled signaling pathways that ultimately lead to analgesia. Lidocaïne, on the other hand, works by blocking sodium channels in nerve cells, preventing the initiation and transmission of nerve impulses and thereby producing local anesthesia.","oneSentence":"Sufentanil is a potent opioid analgesic that acts as a mu-opioid receptor agonist, while Lidocaïne is a local anesthetic that blocks sodium channels.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:36:39.846Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pain management during surgery"}]},"trialDetails":[{"nctId":"NCT02597699","phase":"PHASE3","title":"Use of Ultiva ® Associated With Xylocaine ® in the Procedures of Feticide","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2015-12-18","conditions":"Termination of Pregnancy, Feticide","enrollment":66}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":187,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sufentanil + Xylocaïne®"],"phase":"phase_3","status":"active","brandName":"Sufentanil + Lidocaïne","genericName":"Sufentanil + Lidocaïne","companyName":"University Hospital, Montpellier","companyId":"university-hospital-montpellier","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sufentanil, a mu opioid receptor agonist, is used in combination with lidocaine for procedures such as feticide. This combination is studied in clinical trials for termination of pregnancy and feticide, specifically in the \"Use of Ultiva Associated With Xylocaine in the Procedures of Feticide\" study.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}