{"id":"sufentanil-epidural-bolus","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Sedation"}]},"_chembl":{"chemblId":"CHEMBL1201163","moleculeType":"Small molecule","molecularWeight":"578.68"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sufentanil activates mu-opioid receptors, which are G-protein coupled receptors involved in pain modulation and emotional responses to pain. When administered epidurally as a bolus, it diffuses across the dura mater to act on opioid receptors in the spinal cord and brain, providing rapid onset analgesia. It is approximately 5-10 times more potent than fentanyl.","oneSentence":"Sufentanil is a potent synthetic opioid agonist that binds to mu-opioid receptors in the central and peripheral nervous system to produce analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:10:00.907Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute postoperative pain management via epidural administration"},{"name":"Labor pain analgesia"}]},"trialDetails":[{"nctId":"NCT05930405","phase":"NA","title":"Effect of the PIEB Versus CEI on the Quality of Postoperative Recovery in Patients Undergoing VATS Lobectomy","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2023-10-20","conditions":"Video-assisted Thoracic Surgery","enrollment":252},{"nctId":"NCT07264556","phase":"NA","title":"Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery","status":"RECRUITING","sponsor":"Fudan University","startDate":"2025-11-01","conditions":"Colorectal Cancer, Opioid-free Anesthesia, NETs","enrollment":90},{"nctId":"NCT06779656","phase":"NA","title":"Regional Anesthesia Techniques in Breast Surgery","status":"NOT_YET_RECRUITING","sponsor":"Xiaguang Duan","startDate":"2025-02-01","conditions":"Augmentation, Fibroadenoma, Mastectomy","enrollment":180},{"nctId":"NCT06729515","phase":"NA","title":"Rhomboid Intercostal Block with Subserratus Plane Block in Bariatric Surgery","status":"COMPLETED","sponsor":"Xiaguang Duan","startDate":"2023-01-01","conditions":"Obesity/therapy","enrollment":114},{"nctId":"NCT01856166","phase":"NA","title":"PIEB-PCEA Versus CEI-PCEA for Labor Analgesia in Nulliparous","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2013-06","conditions":"Pregnancy","enrollment":304},{"nctId":"NCT06069219","phase":"","title":"Pharmacokinetics of Sufentanil After Epidural Administration","status":"COMPLETED","sponsor":"Poznan University of Medical Sciences","startDate":"2019-06-01","conditions":"Epidural; Anesthesia, Epidural Analgesia, Abdominal Surgery","enrollment":18},{"nctId":"NCT02573597","phase":"PHASE4","title":"PIEB vs CEI for Labor Analgesia: An MLAC Study","status":"TERMINATED","sponsor":"Stanford University","startDate":"2015-10","conditions":"Pregnancy","enrollment":31},{"nctId":"NCT05196256","phase":"PHASE3","title":"Study Comparing Dural Puncture Epidural With Epidural and Combined Spinal Epidural Anesthesia for Obstetric Analgesia.","status":"UNKNOWN","sponsor":"Brugmann University Hospital","startDate":"2022-06-30","conditions":"Obstetric Pain, Analgesia","enrollment":90},{"nctId":"NCT04657107","phase":"NA","title":"The Efficacy and Safety of S-ketamine in Elective Cesarean Section","status":"UNKNOWN","sponsor":"Beijing Obstetrics and Gynecology Hospital","startDate":"2020-12-01","conditions":"Anesthesia, Analgesia, Depression","enrollment":402},{"nctId":"NCT04538235","phase":"","title":"Analgesic Non Inferiority of the Thoracic Bi-block in Comparison With Thoracic Epidural for VATS.","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2019-10-20","conditions":"Erector Spinae Muscle Plane Block, Serratus Anterior Muscle Plane Block, Video-Assisted Thoracic Surgery","enrollment":90},{"nctId":"NCT01661907","phase":"NA","title":"Anesthesia-analgesia Methods and Postoperative Delirium","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2011-11-21","conditions":"Elderly, Epidural Anesthesia, General Anesthesia","enrollment":1800},{"nctId":"NCT02126332","phase":"PHASE3","title":"Epidural Analgesia for Pancreatitis (Epipan Study)","status":"COMPLETED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2014-06-06","conditions":"Severe Acute Pancreatitis","enrollment":148},{"nctId":"NCT02857465","phase":"PHASE3","title":"Epidural Dexamethasone for Labor Analgesia: the Effects on Ropivacaine Consumption and Labour Outcome","status":"WITHDRAWN","sponsor":"Centre Hospitalier Universitaire de la Réunion","startDate":"2017-01","conditions":"Obstetric Pain, Other Complications of Obstetric Anesthesia - Delivered","enrollment":""},{"nctId":"NCT03007121","phase":"PHASE4","title":"Intrathecal Morphine Analgesia vs. Continuous Epidural Analgesia vs. Systemic Analgesia in Colorectal Surgery.","status":"COMPLETED","sponsor":"Charles University, Czech Republic","startDate":"2017-04-10","conditions":"Analgesia, Patient-Controlled, Epidural Analgesia, Anesthesia; Spinal","enrollment":75},{"nctId":"NCT02563821","phase":"PHASE3","title":"Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG)","status":"COMPLETED","sponsor":"University Hospital, Limoges","startDate":"2015-11-05","conditions":"Anesthesia, Epidural","enrollment":37},{"nctId":"NCT03366935","phase":"NA","title":"Combined Implementation of Dural Puncture Epidural and Programmed Intermittent Epidural Bolus for Labor Analgesia","status":"COMPLETED","sponsor":"Shanghai First Maternity and Infant Hospital","startDate":"2017-10-10","conditions":"Labor Pain, Labor Analgesia","enrollment":120},{"nctId":"NCT03600272","phase":"NA","title":"Comparison of Combined Spinal-epidural Analgesia Versus Epidural Analgesia for Pain Management During Labor","status":"UNKNOWN","sponsor":"Deng Dongrui","startDate":"2018-07-20","conditions":"Labor Long, Labor Pain, Labor Fetal Anoxia","enrollment":200},{"nctId":"NCT03381495","phase":"NA","title":"The Association Between Epidural Labor Analgesia and Pregnancy Outcomes","status":"UNKNOWN","sponsor":"Deng Dongrui","startDate":"2018-05-16","conditions":"Labor Pain, Pregnancy Outcomes, Psychological Disorder","enrollment":200},{"nctId":"NCT02705872","phase":"PHASE2","title":"Comparison of Two Methods of Administration of the Epidural, by Programmed Intermittent Bolus or Continuous Perfusion, on the Incidence of Cesarean Sections and Instrumented Deliveries in Primiparous Women","status":"WITHDRAWN","sponsor":"Brugmann University Hospital","startDate":"2016-03-08","conditions":"First Child Delivery With Epidural","enrollment":""},{"nctId":"NCT02710877","phase":"NA","title":"Intermittent Automated Devices for Labor Analgesia in Emilia Romagna","status":"TERMINATED","sponsor":"University of Modena and Reggio Emilia","startDate":"2014-12-23","conditions":"Labor Pain","enrollment":671},{"nctId":"NCT02920489","phase":"NA","title":"Individualized Timing of Analgesia and Effectiveness of Labor Analgesia","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2016-08","conditions":"Labor Pain, Analgesia, Obstetrical, Early Medical Intervention","enrollment":200},{"nctId":"NCT03185403","phase":"NA","title":"The Hemodynamic Effect Between Two Types of Anesthesia in Esophageal Surgery","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2013-12","conditions":"Epidural Block, Oesophageal Cancer, Oesophagectomy","enrollment":54},{"nctId":"NCT02873091","phase":"NA","title":"Comparison of Programmed Intermittent Epidural Bolus With Continuous Epidural Infusion for Labor Epidural Analgesia","status":"UNKNOWN","sponsor":"Nanjing Maternity and Child Health Care Hospital","startDate":"2016-09","conditions":"Labor Analgesia","enrollment":186},{"nctId":"NCT02677532","phase":"PHASE4","title":"Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair","status":"COMPLETED","sponsor":"University of Genova","startDate":"2011-12","conditions":"Postoperative Pain","enrollment":51},{"nctId":"NCT02647047","phase":"NA","title":"Spinal Versus Epidural Analgesia in Laparotomic Liver Surgery","status":"UNKNOWN","sponsor":"Ospedale San Raffaele","startDate":"2016-01","conditions":"Secondary Malignant Neoplasm of Liver, Liver Diseases, Liver Neoplasms","enrollment":40},{"nctId":"NCT01860521","phase":"NA","title":"Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Termination of Pregnancy Analgesia","status":"COMPLETED","sponsor":"IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","startDate":"2011-09","conditions":"Medical; 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Used for Acute postoperative pain management via epidural administration, Labor pain analgesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}