{"id":"succinylcholine-neostigmine","safety":{"commonSideEffects":[{"rate":null,"effect":"Muscle fasciculations"},{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Malignant hyperthermia (succinylcholine-related)"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Increased salivation"},{"rate":null,"effect":"Bronchospasm"}]},"_chembl":{"chemblId":"CHEMBL278020","moleculeType":"Small molecule","molecularWeight":"223.30"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Succinylcholine is a depolarizing agent that binds to nicotinic acetylcholine receptors at the neuromuscular junction, causing sustained depolarization and muscle paralysis. Neostigmine is a cholinesterase inhibitor that prevents the breakdown of acetylcholine, thereby increasing acetylcholine concentration and competitively reversing the neuromuscular blockade induced by succinylcholine. This combination is used to manage the duration and reversal of succinylcholine-induced paralysis during anesthesia.","oneSentence":"Succinylcholine causes depolarizing neuromuscular blockade while neostigmine reverses it by inhibiting acetylcholinesterase, allowing acetylcholine to accumulate at the neuromuscular junction.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:09:56.051Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reversal of depolarizing neuromuscular blockade induced by succinylcholine during general anesthesia"}]},"trialDetails":[{"nctId":"NCT03962725","phase":"PHASE4","title":"Avoiding Neuromuscular Blockers to Reduce Complications","status":"TERMINATED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2019-08-07","conditions":"Respiratory Failure, Respiratory Infection, Aspiration Pneumonia","enrollment":3},{"nctId":"NCT02914119","phase":"","title":"Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals","status":"COMPLETED","sponsor":"Jakob Louis Thomsen","startDate":"2016-10-01","conditions":"Neuromuscular Blockade","enrollment":30430},{"nctId":"NCT01718236","phase":"PHASE4","title":"Modern Myorelaxation Procedure and Reversal of Neuromuscular Blockade With General Anesthesia for Caesarean Section","status":"COMPLETED","sponsor":"Brno University Hospital","startDate":"2012-09","conditions":"Caesarean Section, Pregnancy","enrollment":500},{"nctId":"NCT02329964","phase":"PHASE4","title":"Effectiveness of Sugammadex in LMS Surgery","status":"UNKNOWN","sponsor":"Korea University Anam Hospital","startDate":"2015-02","conditions":"Muscle Relaxation","enrollment":80},{"nctId":"NCT02410590","phase":"PHASE4","title":"Rocuronium + Sugammadex vs. Succinylcholine + Cisatracurium + Neostigmine/Atropine in Obese Participants (MK-8616-104)","status":"WITHDRAWN","sponsor":"Merck Sharp & Dohme LLC","startDate":"2015-07","conditions":"Neuromuscular Blockade","enrollment":""},{"nctId":"NCT01966484","phase":"NA","title":"Low Dose Mivacurium vs. Low Dose Succinylcholine for Rigid Bronchoscopy","status":"COMPLETED","sponsor":"Dr. Horst Schmidt Klinik GmbH","startDate":"2013-10","conditions":"Intubating Conditions, Performance With Respiratory Exercise Device, Postoperative Myalgia","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":174,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Succinylcholine + Neostigmine","genericName":"Succinylcholine + Neostigmine","companyName":"Brno University Hospital","companyId":"brno-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Succinylcholine causes depolarizing neuromuscular blockade while neostigmine reverses it by inhibiting acetylcholinesterase, allowing acetylcholine to accumulate at the neuromuscular junction. Used for Reversal of depolarizing neuromuscular blockade induced by succinylcholine during general anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}