{"id":"submucosal-injection-of-indocyanine-green","safety":{"commonSideEffects":[{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Local injection site reaction"},{"rate":null,"effect":"Anaphylaxis (rare)"}]},"_chembl":{"chemblId":"CHEMBL1646","moleculeType":"Small molecule","molecularWeight":"774.98"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"When injected into the submucosal layer, ICG fluoresces in the near-infrared spectrum (700–900 nm), allowing surgeons to visualize lymph nodes, blood vessels, and tissue planes intraoperatively using specialized imaging equipment. This enhanced visualization improves surgical precision and completeness of resection, particularly in colorectal and gastrointestinal oncology procedures.","oneSentence":"Indocyanine green (ICG) is a near-infrared fluorescent dye injected submucosally to provide real-time optical imaging and visualization of tissue during surgical procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:36:39.086Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intraoperative visualization and lymph node mapping in colorectal cancer surgery"},{"name":"Sentinel lymph node identification in gastrointestinal malignancies"}]},"trialDetails":[{"nctId":"NCT06788548","phase":"NA","title":"Fluorescence Guided Laparoscopic-Endoscopic Cooperative Sentinel Lymph Node Navigation Surgery Strategy for Early Gastric Cancer","status":"RECRUITING","sponsor":"Beijing Friendship Hospital","startDate":"2024-02-03","conditions":"Early Gastric Cancer","enrollment":312},{"nctId":"NCT07380867","phase":"NA","title":"Confirming the Accuracy of Endoscopic Marking Using a New Marker, a Novel Luminomarker, in Lesion Marking Before Colorectal Cancer Surgery.","status":"ENROLLING_BY_INVITATION","sponsor":"Seoul St. Mary's Hospital","startDate":"2025-12-22","conditions":"Colorectal Cancer, Endoscopic Tattoo of Suspected Colon Cancer, Indocyanine Green (ICG)","enrollment":30},{"nctId":"NCT06652672","phase":"NA","title":"Sentinel Node and Organ-sparing Surgery in Stage I Colon Carcinoma","status":"RECRUITING","sponsor":"Meander Medical Center","startDate":"2024-12-12","conditions":"Colon Cancer, Colon Adenocarcinoma, Sentinel Lymph Node","enrollment":341},{"nctId":"NCT07060443","phase":"PHASE2","title":"Fluorescence Lymph Node Mapping for Colon Cancer Surgery","status":"RECRUITING","sponsor":"Pusan National University Yangsan Hospital","startDate":"2025-07-23","conditions":"Right Hemicolectomy","enrollment":186},{"nctId":"NCT06755554","phase":"PHASE3","title":"Investigation of Impact of Indocyanine Green on Volume of Lymphadenectomy in Resectable Gastric Cancer","status":"RECRUITING","sponsor":"Ukrainian Society of Clinical Oncology","startDate":"2025-01-01","conditions":"Gastric Cancer Stage II, Gastric Cancer Stage III, Gastric Cancer","enrollment":105},{"nctId":"NCT04943484","phase":"","title":"ICG (Indocyanine Green) Imaging Fluorescence Technology in Surgical Treatment of Advanced Gastric Cancer","status":"RECRUITING","sponsor":"Niguarda Hospital","startDate":"2022-01-01","conditions":"Gastric Cancer","enrollment":360},{"nctId":"NCT06421220","phase":"NA","title":"Evaluation of the Efficacy and Safety of Indocyanine Green Tracing in 3D Fluorescent Laparoscopic Lymph Node Dissection for Gastric Cancer","status":"NOT_YET_RECRUITING","sponsor":"Qilu Hospital of Shandong University","startDate":"2024-05-20","conditions":"Gastric Cancer","enrollment":484},{"nctId":"NCT04219332","phase":"PHASE3","title":"Randomized Controlled Trial on Effect of Lymph Node Mapping by Indocyanine Green Via Submucosal or Subserosal Injection","status":"UNKNOWN","sponsor":"Fujian Medical University","startDate":"2019-12-31","conditions":"Indocyanine Green, Gastric Cancer, Injection Site","enrollment":266},{"nctId":"NCT04143555","phase":"","title":"Endoscopic Submucosal Injection of Indocyanine Green Before Laparoscopic Gastrectomy","status":"UNKNOWN","sponsor":"Jilin University","startDate":"2019-11-20","conditions":"Endoscopic Submucosal Injection of Indocyanine Green","enrollment":130},{"nctId":"NCT04173676","phase":"PHASE1","title":"Sentinel Lymph Node Navigation Surgery Using Near-infrared Imaging in Early Esophageal Cancer","status":"UNKNOWN","sponsor":"Fifth Affiliated Hospital, Sun Yat-Sen University","startDate":"2019-12-02","conditions":"Detection Rate of SLN ; Accuracy Rate of Lymph Node Metastasis","enrollment":84},{"nctId":"NCT04207489","phase":"","title":"Endoscopic Submucosal Injection of Indocyanine Green Before Laparoscopic Radical Resection for Colorectal Cancer","status":"UNKNOWN","sponsor":"Jilin University","startDate":"2020-04-15","conditions":"Colorectal Cancer, Indocyanine Green","enrollment":100},{"nctId":"NCT03647540","phase":"NA","title":"The Application of Fluorescence Laparoscopy in the Treatment of Adenocarcinoma of the Esophagogastric Junction","status":"UNKNOWN","sponsor":"Dong Yang","startDate":"2018-08-30","conditions":"Fluorescence Laparoscopy, Adenocarcinoma of the Esophagogastric Junction","enrollment":164},{"nctId":"NCT03854890","phase":"NA","title":"Fluorescent Lymphography-Guided Lymphadenectomy In Laparoscopic Proctectomy","status":"UNKNOWN","sponsor":"Fudan University","startDate":"2019-07-01","conditions":"Rectal Cancer","enrollment":100},{"nctId":"NCT02850783","phase":"PHASE2, PHASE3","title":"SLN in Colon Cancer Using a Multimodal Tracer","status":"COMPLETED","sponsor":"VU University of Amsterdam","startDate":"2015-03","conditions":"Sentinel Lymph Node","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["No other intervention"],"phase":"phase_3","status":"active","brandName":"submucosal injection of indocyanine green","genericName":"submucosal injection of indocyanine green","companyName":"Fujian Medical University","companyId":"fujian-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Indocyanine green (ICG) is a near-infrared fluorescent dye injected submucosally to provide real-time optical imaging and visualization of tissue during surgical procedures. Used for Intraoperative visualization and lymph node mapping in colorectal cancer surgery, Sentinel lymph node identification in gastrointestinal malignancies.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}