{"id":"sublingual-immunotherapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral pruritus"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Mild local swelling"},{"rate":null,"effect":"Gastrointestinal symptoms"}]},"_chembl":null,"_dailymed":{"setId":"720a7575-57b8-498e-8b67-e5374836e123","title":"ALLERGENA PET DANDER (HOMEOPATHIC SUBLINGUAL IMMUNOTHERAPY) LIQUID [MEDITREND, INC. DBA PROGENA PROFESSIONAL FORMULATIONS]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This treatment works by gradually exposing the immune system to small, increasing doses of allergen antigens placed under the tongue, where specialized immune cells promote tolerance rather than allergic sensitization. Over time, this desensitization reduces the production of allergic antibodies (IgE) and increases regulatory T cells and blocking antibodies (IgG4), leading to decreased allergic symptoms upon natural allergen exposure.","oneSentence":"Sublingual immunotherapy delivers allergen extracts under the tongue to induce immune tolerance and reduce allergic responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:09:57.877Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis"},{"name":"Allergic asthma"}]},"trialDetails":[{"nctId":"NCT07419230","phase":"NA","title":"Evaluation of a Digital Tool to Improve Aeroallergen Immunotherapy Adherence. 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