{"id":"strychnine","rwe":[{"pmid":"41889748","year":"2026","title":"A Total Synthesis of (-)-Strychnine Using Photoredox Catalysis.","finding":"","journal":"JACS Au","studyType":"Clinical Study"},{"pmid":"41804241","year":"2026","title":"Quorum Quenching Potential of the Indigenous Kalimantan Fern Stenochlaena palustris Against Pseudomonas aeruginosa.","finding":"","journal":"Pakistan journal of biological sciences : PJBS","studyType":"Clinical Study"},{"pmid":"41747779","year":"2026","title":"TAS2R46 activation protects intestinal barrier from chronic high glucose.","finding":"","journal":"Brain, behavior, and immunity","studyType":"Clinical Study"},{"pmid":"41740957","year":"2026","title":"Material Characterization of Ethanolic Preparation of Nux vomica: Structural and Functional Analysis from Mother Tincture to 200cH.","finding":"","journal":"Homeopathy : the journal of the Faculty of Homeopathy","studyType":"Clinical Study"},{"pmid":"41729036","year":"2026","title":"Adsorption of colchicine, hydroxychloroquine, ibuprofen, and strychnine to activated charcoal.","finding":"","journal":"Clinical toxicology (Philadelphia, Pa.)","studyType":"Clinical Study"}],"tags":[{"label":"strychnine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Taste receptor type 2 member 46","category":"target"},{"label":"TAS2R46","category":"gene"},{"label":"CHRM3","category":"gene"},{"label":"TAS2R10","category":"gene"},{"label":"Active","category":"status"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Stimulants","category":"pharmacology"},{"label":"Convulsants","category":"pharmacology"},{"label":"Glycine Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Noxae","category":"pharmacology"},{"label":"Poisons","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"strychnin","offLabel":[],"synonyms":["strychnine","Strychnidin-10-one","(-)-Strychnine","strychnin","strychnine hydrochloride","strychnine sulfate","strychnine HCl"],"timeline":[],"approvals":[],"brandName":"Strychnin","ecosystem":[],"mechanism":{"target":"Taste receptor type 2 member 10, Taste receptor type 2 member 46, Glycine receptor subunit alpha-1","targets":[{"gene":"TAS2R46","source":"DrugCentral","target":"Taste receptor type 2 member 46","protein":"Taste receptor type 2 member 46"},{"gene":"CHRM3","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M3","protein":"Muscarinic acetylcholine receptor M3"},{"gene":"TAS2R10","source":"DrugCentral","target":"Taste receptor type 2 member 10","protein":"Taste receptor type 2 member 10"},{"gene":"CHRM1","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M1","protein":"Muscarinic acetylcholine receptor M1"},{"gene":"CHRM2","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M2","protein":"Muscarinic acetylcholine receptor M2"},{"gene":"CHRM4","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M4","protein":"Muscarinic acetylcholine receptor M4"},{"gene":"GLRA1","source":"DrugCentral","target":"Glycine receptor subunit alpha-1","protein":"Glycine receptor subunit alpha-1"},{"gene":"SCN1A","source":"DrugCentral","target":"Sodium channel alpha subunits; brain (Types I, II, III)","protein":"Sodium channel protein type 1 subunit alpha"},{"gene":"SCN2A","source":"DrugCentral","target":"Sodium channel alpha subunits; brain (Types I, II, III)","protein":"Sodium channel protein type 2 subunit alpha"},{"gene":"SCN3A","source":"DrugCentral","target":"Sodium channel alpha subunits; brain (Types I, II, III)","protein":"Sodium channel protein type 3 subunit alpha"}],"modality":"Small Molecule","drugClass":"strychnine","explanation":"Imagine your taste buds have special sensors that help you detect different flavors. Strychnine is a small molecule that can bind to one of these sensors, called the taste receptor type 2 member 46, which is responsible for detecting bitter tastes. By binding to this sensor, strychnine can alter the way you perceive bitter flavors.","oneSentence":"Strychnine works by binding to the taste receptor type 2 member 46, which is involved in the detection of bitter tastes.","technicalDetail":"Strychnine acts as a competitive antagonist at the T2R46 receptor, which is a G-protein coupled receptor that plays a key role in the detection of bitter compounds in the diet."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2484","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=strychnine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:43:15.939879","biosimilars":[],"competitors":[{"drugName":"acetylcholine","drugSlug":"acetylcholine","fdaApproval":"1973-10-09","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"aclidinium bromide","drugSlug":"aclidinium-bromide","fdaApproval":"2012-07-23","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amitriptyline","drugSlug":"amitriptyline","fdaApproval":"1961-04-07","genericCount":33,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amoxapine","drugSlug":"amoxapine","fdaApproval":"1980-09-22","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"aripiprazole","drugSlug":"aripiprazole","fdaApproval":"2002-11-15","patentExpiry":"Sep 24, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"asenapine","drugSlug":"asenapine","fdaApproval":"2009-08-13","patentExpiry":"Sep 22, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-target"},{"drugName":"atropine","drugSlug":"atropine","fdaApproval":"1960-09-15","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"azelastine","drugSlug":"azelastine","fdaApproval":"1996-11-01","patentExpiry":"Jun 4, 2028","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"strychnine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acetylcholine","brandName":"acetylcholine","genericName":"acetylcholine","approvalYear":"1973","relationship":"same-target"},{"drugId":"aclidinium-bromide","brandName":"aclidinium bromide","genericName":"aclidinium bromide","approvalYear":"2012","relationship":"same-target"},{"drugId":"amiodarone","brandName":"amiodarone","genericName":"amiodarone","approvalYear":"1985","relationship":"same-target"},{"drugId":"amitriptyline","brandName":"amitriptyline","genericName":"amitriptyline","approvalYear":"1961","relationship":"same-target"},{"drugId":"amoxapine","brandName":"amoxapine","genericName":"amoxapine","approvalYear":"1980","relationship":"same-target"},{"drugId":"aripiprazole","brandName":"aripiprazole","genericName":"aripiprazole","approvalYear":"2002","relationship":"same-target"},{"drugId":"asenapine","brandName":"asenapine","genericName":"asenapine","approvalYear":"2009","relationship":"same-target"},{"drugId":"astemizole","brandName":"astemizole","genericName":"astemizole","approvalYear":"1988","relationship":"same-target"},{"drugId":"atropine","brandName":"atropine","genericName":"atropine","approvalYear":"1960","relationship":"same-target"},{"drugId":"azelastine","brandName":"azelastine","genericName":"azelastine","approvalYear":"1996","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000148019","MMSL":"NOCODE","NDDF":"001377","UNII":"H9Y79VD43J","VUID":"4019934","CHEBI":"CHEBI:28973","VANDF":"4019131","RXNORM":"236074","UMLSCUI":"C0202474","ChEMBL_ID":"CHEMBL227934","DRUGBANK_ID":"DB15954","PDB_CHEM_ID":" SY9","PUBCHEM_CID":"441071","SNOMEDCT_US":"354051007","IUPHAR_LIGAND_ID":"347","SECONDARY_CAS_RN":"1421-86-9","MESH_DESCRIPTOR_UI":"D013331"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5213,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 23","pmid":"41889748","title":"A Total Synthesis of (-)-Strychnine Using Photoredox Catalysis.","journal":"JACS Au"},{"date":"2026 Feb","pmid":"41804241","title":"Quorum Quenching Potential of the Indigenous Kalimantan Fern Stenochlaena palustris Against Pseudomonas aeruginosa.","journal":"Pakistan journal of biological sciences : PJBS"},{"date":"2026 Feb 24","pmid":"41747779","title":"TAS2R46 activation protects intestinal barrier from chronic high glucose.","journal":"Brain, behavior, and immunity"},{"date":"2026 Feb 25","pmid":"41740957","title":"Material Characterization of Ethanolic Preparation of Nux vomica: Structural and Functional Analysis from Mother Tincture to 200cH.","journal":"Homeopathy : the journal of the Faculty of Homeopathy"},{"date":"2026 Feb 23","pmid":"41729036","title":"Adsorption of colchicine, hydroxychloroquine, ibuprofen, and strychnine to activated charcoal.","journal":"Clinical toxicology (Philadelphia, Pa.)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Strychnine is a highly toxic, colorless, crystalline alkaloid used as a pesticide to kill small vertebrates such as birds and rodents. It causes poisoning that results in muscular convulsions and eventually death through asphyxia when inhaled, swallowed, or absorbed through the eyes or mouth.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}