{"id":"stepped-care","safety":{"commonSideEffects":[{"rate":null,"effect":"Depression"},{"rate":null,"effect":"Anxiety"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This approach allows for a more personalized and effective treatment plan, as patients receive the most intensive level of care necessary to achieve optimal outcomes. Stepped care can be particularly useful in managing chronic conditions, such as depression or anxiety, where patients may require varying levels of support over time.","oneSentence":"Stepped care is a treatment approach that involves a gradual escalation of interventions based on patient response.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:36:36.592Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Major depressive disorder"},{"name":"Anxiety disorders"}]},"trialDetails":[{"nctId":"NCT07458100","phase":"NA","title":"The STEP-MIED Trial: Digital Stepped-Care for Emotional Disorders","status":"RECRUITING","sponsor":"Peking University","startDate":"2026-03","conditions":"Emotional Disorders, Depressive Disorder, Anxiety Disorders","enrollment":464},{"nctId":"NCT06156293","phase":"NA","title":"Prevention of Insomnia Using a Stepped Care Model in Adults","status":"RECRUITING","sponsor":"Chinese University of Hong Kong","startDate":"2023-12-01","conditions":"Sleep Disturbance","enrollment":1016},{"nctId":"NCT05140421","phase":"NA","title":"Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program","status":"ACTIVE_NOT_RECRUITING","sponsor":"City University of New York","startDate":"2021-12-15","conditions":"Hiv","enrollment":1494},{"nctId":"NCT04989790","phase":"NA","title":"Clinical Effectiveness of the \"PICU Up!\" Multifaceted Early Mobility Intervention for Critically Ill Children","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2022-08-08","conditions":"Child, Intensive Care Unit Acquired Weakness, Critical Illness","enrollment":1440},{"nctId":"NCT04935710","phase":"NA","title":"Prevention and Early Identification for High Risk Youth in School-based Clinics","status":"COMPLETED","sponsor":"Cambridge Health Alliance","startDate":"2022-01-03","conditions":"Community Mental Health Services, Adolescent Well Being, Resilience, Psychological","enrollment":39},{"nctId":"NCT07476040","phase":"NA","title":"Improved Management of Patients With Recent-Onset Stable Chest Pain","status":"NOT_YET_RECRUITING","sponsor":"Philipps University Marburg","startDate":"2026-04","conditions":"Coronary Artery Disease (CAD)","enrollment":3369},{"nctId":"NCT02836080","phase":"NA","title":"Integrated Collaborative Care Teams for Youth With Mental Health and/or Addiction Challenges (YouthCan IMPACT)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Centre for Addiction and Mental Health","startDate":"2016-09","conditions":"Mental Disorders, Addiction","enrollment":247},{"nctId":"NCT06331364","phase":"NA","title":"TREATment of Lower Respiratory Tract Infection in Selected Hospitals in Southern Sri Lanka (TREAT-SL): a Stepped-Wedge Cluster Randomized Trial","status":"RECRUITING","sponsor":"Duke University","startDate":"2026-02-27","conditions":"Lower Resp Tract Infection","enrollment":765},{"nctId":"NCT06515574","phase":"NA","title":"Effect of Developmental Care on Very Low Birth Weight Infants","status":"RECRUITING","sponsor":"Children's Hospital of Fudan University","startDate":"2024-08-30","conditions":"Intervention","enrollment":1600},{"nctId":"NCT06947538","phase":"NA","title":"Stepped Care for Posttraumatic Stress Disorder Study","status":"RECRUITING","sponsor":"Boston Medical Center","startDate":"2026-03-12","conditions":"Post Traumatic Stress Disorder","enrollment":428},{"nctId":"NCT07469917","phase":"NA","title":"Safety Planning Intervention in Swedish Healthcare: A Multisite Study for Suicide Prevention","status":"RECRUITING","sponsor":"Region Skane","startDate":"2025-10-01","conditions":"Suicide Attempt","enrollment":8000},{"nctId":"NCT07218198","phase":"NA","title":"Clinical Decision Support Tool for the Treatment of Uncontrolled Hypertension","status":"NOT_YET_RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2026-05-01","conditions":"Hypertension, Hypertension (HTN), Blood Pressure, High","enrollment":168},{"nctId":"NCT06035445","phase":"NA","title":"Support for Adolescents Living With HIV in South Africa","status":"ACTIVE_NOT_RECRUITING","sponsor":"Emory University","startDate":"2024-02-02","conditions":"Human Immunodeficiency Virus, HIV","enrollment":570},{"nctId":"NCT07347015","phase":"NA","title":"Prescription Support System for Antimicrobial Use in Belgian Primary Care","status":"RECRUITING","sponsor":"KU Leuven","startDate":"2025-12-21","conditions":"Infectious Diseases","enrollment":48},{"nctId":"NCT06905002","phase":"NA","title":"Enhancing the Patient Journey to Clinical Trial Enrolment With Navigation to Optimize Accrual","status":"RECRUITING","sponsor":"Windsor Regional Hospital","startDate":"2025-04-01","conditions":"Cancer","enrollment":300},{"nctId":"NCT06902649","phase":"NA","title":"Step-by-Step: Evaluation of a Stepped Care Model","status":"RECRUITING","sponsor":"Karolinska Institutet","startDate":"2025-04-02","conditions":"Child Behavior Problem, Disruptive Behavior, Oppositional Defiant Disorder","enrollment":210},{"nctId":"NCT05530694","phase":"NA","title":"Rheumatoid Arthritis Shared Decision Making","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2022-09-19","conditions":"Rheumatoid Arthritis","enrollment":900},{"nctId":"NCT05222386","phase":"NA","title":"Community Outreach for Palliative Engagement -- Parkinson Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Rochester","startDate":"2022-04-26","conditions":"Parkinson Disease Dementia, Parkinson Disease, Parkinson's Disease and Parkinsonism","enrollment":632},{"nctId":"NCT07452406","phase":"NA","title":"Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients","status":"NOT_YET_RECRUITING","sponsor":"Rush University Medical Center","startDate":"2026-06-01","conditions":"Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy","enrollment":2000},{"nctId":"NCT07454083","phase":"","title":"Real-World Study of Acupuncture for Pain Control","status":"NOT_YET_RECRUITING","sponsor":"Qi's Clinic","startDate":"2026-03-21","conditions":"Non-Cancer Pain,Musculoskeletal Pain,Chronic Pain,Acute Pain","enrollment":300},{"nctId":"NCT06431022","phase":"NA","title":"Web-administered STAIR for Patients on Behavioral Health Waitlists","status":"ACTIVE_NOT_RECRUITING","sponsor":"Boston Medical Center","startDate":"2024-11-15","conditions":"Post Traumatic Stress Disorder","enrollment":70},{"nctId":"NCT07340580","phase":"NA","title":"Implementation Facilitation of Exercise is Medicine Greenville","status":"NOT_YET_RECRUITING","sponsor":"University of South Carolina","startDate":"2026-05-01","conditions":"Physical Inactivity, Dyslipidemia, Obesity and Overweight","enrollment":35},{"nctId":"NCT07228143","phase":"NA","title":"Stepped Care Treatment for Anxiety Resilience","status":"RECRUITING","sponsor":"Andrew Wiese","startDate":"2026-01-05","conditions":"Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD), Separation Anxiety Disorder","enrollment":106},{"nctId":"NCT06219408","phase":"NA","title":"CIH Stepped Care for Co-occurring Chronic Pain and PTSD","status":"RECRUITING","sponsor":"University of Washington","startDate":"2026-02-18","conditions":"Chronic Pain, Posttraumatic Stress Disorder","enrollment":60},{"nctId":"NCT06644599","phase":"NA","title":"Wireless Monitoring for Clinical Deterioration","status":"RECRUITING","sponsor":"King Abdullah International Medical Research Center","startDate":"2026-02-01","conditions":"Inpatient Facililty Diagnoses","enrollment":13160},{"nctId":"NCT06942429","phase":"NA","title":"Stepped Versus Stratified Care for Anxiety Disorders in Youth","status":"RECRUITING","sponsor":"Region Skane","startDate":"2025-06-19","conditions":"Social Anxiety Disorder, Separation Anxiety Disorder, Specific Phobia","enrollment":556},{"nctId":"NCT03060096","phase":"NA","title":"Stepped-Care Telehealth for Distress in Cancer Survivors","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2018-07-19","conditions":"Anxiety, Depressive Symptoms, Sleep Disturbance","enrollment":68},{"nctId":"NCT06782126","phase":"","title":"A Study Protocol for the Implementation and Evaluation of a Self-management Support Program in Burns Aftercare for Burn Survivors in the Netherlands","status":"ACTIVE_NOT_RECRUITING","sponsor":"Martini Hospital Groningen","startDate":"2024-04-15","conditions":"Burns","enrollment":146},{"nctId":"NCT07213908","phase":"NA","title":"Comparing Two School-Based Sleep Health Interventions To Promote Sleep Quality in Youth","status":"RECRUITING","sponsor":"Children's Hospital Los Angeles","startDate":"2026-03-01","conditions":"Sleep","enrollment":1320},{"nctId":"NCT06343545","phase":"NA","title":"The Tele-Rehab MV Cluster Stepped-Wedge Randomized Clinical Trial","status":"COMPLETED","sponsor":"Hospital Israelita Albert Einstein","startDate":"2024-06-10","conditions":"Acute Respiratory Failure","enrollment":1916},{"nctId":"NCT06945055","phase":"NA","title":"FAmily Engagement Strategy for Coordinated Specialty Care","status":"RECRUITING","sponsor":"Washington State University","startDate":"2025-03-01","conditions":"Family Members, Implementation","enrollment":900},{"nctId":"NCT07024498","phase":"NA","title":"Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment","status":"NOT_YET_RECRUITING","sponsor":"University of California, Davis","startDate":"2026-03-01","conditions":"Opioid Use Disorder","enrollment":3492},{"nctId":"NCT07423858","phase":"NA","title":"Predicting The Right Advice at The Right Time in Patients With Hip and Knee OsteoArthritis: the e-cOAch Cross-over.","status":"RECRUITING","sponsor":"UMC Utrecht","startDate":"2025-09-01","conditions":"Osteo Arthritis Knee and Hip","enrollment":600},{"nctId":"NCT06184945","phase":"NA","title":"Behavioral Economic & Staffing Strategies in the ICU","status":"RECRUITING","sponsor":"University of Nebraska","startDate":"2024-07-01","conditions":"Implementation Science, Delirium, Critical Illness","enrollment":8100},{"nctId":"NCT07115030","phase":"NA","title":"Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery","status":"NOT_YET_RECRUITING","sponsor":"Yale University","startDate":"2026-03","conditions":"Opioid Use Disorder, Intimate Partner Violence (IPV), Post Traumatic Stress Disorder PTSD","enrollment":532},{"nctId":"NCT07327450","phase":"NA","title":"Coaching Doctors and Nurses to Improve Ethical Decision-making in Team","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Ghent","startDate":"2026-04-01","conditions":"Decision Making ,Shared, Leadership, End of Life Communication","enrollment":360},{"nctId":"NCT06290869","phase":"PHASE3","title":"Tobacco Education and Lung Health Study (TEAL)","status":"RECRUITING","sponsor":"Georgetown University","startDate":"2024-02-22","conditions":"Smoking Cessation","enrollment":1188},{"nctId":"NCT06596577","phase":"PHASE3","title":"Nudging Effective and Equitable Delivery of Specialty Palliative Care","status":"ENROLLING_BY_INVITATION","sponsor":"University of Pennsylvania","startDate":"2025-08-06","conditions":"Serious Illness, Palliative","enrollment":18000},{"nctId":"NCT07411183","phase":"NA","title":"A Pilot RCT Examining the Effectiveness of CMT for Healthcare Staff","status":"RECRUITING","sponsor":"Queen's University, Belfast","startDate":"2025-10-13","conditions":"Staff Support","enrollment":60},{"nctId":"NCT05934877","phase":"NA","title":"ASK-PrEP (Assistance Services Knowledge-PrEP)","status":"TERMINATED","sponsor":"Friends Research Institute, Inc.","startDate":"2023-05-11","conditions":"Substance Use Disorders, HIV","enrollment":152},{"nctId":"NCT05179759","phase":"NA","title":"Teachers Leading the Frontlines (Tealeaf) - a Hybrid Effectiveness, Implement, and Context Trial","status":"ENROLLING_BY_INVITATION","sponsor":"University of North Carolina, Chapel Hill","startDate":"2022-02-20","conditions":"Child Behavior Disorders","enrollment":20160},{"nctId":"NCT05626452","phase":"NA","title":"PrEP Optimization Among Women to Enhance Retention and Uptake","status":"RECRUITING","sponsor":"University of Chicago","startDate":"2023-08-10","conditions":"PrEP Uptake","enrollment":680},{"nctId":"NCT07399314","phase":"NA","title":"Evaluating the Effectiveness of a School-based Stepped Care Treatment Model for Adolescent Depression in Pakistan","status":"COMPLETED","sponsor":"Global Institute of Human Development","startDate":"2025-11-13","conditions":"Depression Anxiety Disorder, Psychological Distress, Well-Being, Psychological","enrollment":600},{"nctId":"NCT05213676","phase":"PHASE4","title":"De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia","status":"RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2025-11-01","conditions":"Congenital Diaphragmatic Hernia","enrollment":600},{"nctId":"NCT07396974","phase":"NA","title":"Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (RCT)","status":"NOT_YET_RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2026-09-01","conditions":"Trauma, Posttraumatic Stress Disorder","enrollment":30},{"nctId":"NCT07396935","phase":"NA","title":"Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (Pilot)","status":"NOT_YET_RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2026-04-01","conditions":"Trauma, Posttraumatic Stress Disorder","enrollment":7},{"nctId":"NCT07398053","phase":"NA","title":"General Practitioner & Pharmacist Support for Discontinuing Long-term Antidepressants in Clinically Stable Patients","status":"NOT_YET_RECRUITING","sponsor":"University Ghent","startDate":"2026-03-01","conditions":"Deprescribing, Antidepressant, Depression Disorder","enrollment":324},{"nctId":"NCT07290361","phase":"NA","title":"Stratified Targeted Engagement From Primary Care to Physical Therapy (STEPPT)","status":"RECRUITING","sponsor":"San Diego State University","startDate":"2025-12-01","conditions":"Low Back Pain, Neck Pain","enrollment":17587},{"nctId":"NCT03537963","phase":"NA","title":"Improving Sleep in BMT Survivors","status":"COMPLETED","sponsor":"H. Lee Moffitt Cancer Center and Research Institute","startDate":"2018-05-15","conditions":"Sleep Disturbance, Sleep Disorder","enrollment":30},{"nctId":"NCT04432129","phase":"NA","title":"Integrated Mental Health Care and Vocational Rehabilitation to People With to Common Mental Disorders","status":"COMPLETED","sponsor":"Amager Hospital","startDate":"2020-06-09","conditions":"Common Mental Disorders, Depression, Anxiety","enrollment":900},{"nctId":"NCT03113175","phase":"NA","title":"Collabri Flex - Effect of Collaborative Care for People With Anxiety Disorders in General Practice","status":"COMPLETED","sponsor":"Amager Hospital","startDate":"2018-01-15","conditions":"Panic Disorder, Generalized Anxiety Disorder, Social Phobia","enrollment":302},{"nctId":"NCT02885519","phase":"NA","title":"Integrated Mental Health Care and Vocational Rehabilitation to Individuals on Sick Leave Due to Stress Disorders","status":"COMPLETED","sponsor":"Amager Hospital","startDate":"2016-04","conditions":"Adjustment Disorder, Burnout, Psychological Stress","enrollment":631},{"nctId":"NCT02872051","phase":"NA","title":"Integrated Mental Health Care and Vocational Rehabilitation to Individuals on Sick Leave Due to Anxiety and Depression","status":"COMPLETED","sponsor":"Amager Hospital","startDate":"2016-04","conditions":"Generalized Anxiety, Social Phobia, Panic Disorder","enrollment":631},{"nctId":"NCT02678845","phase":"NA","title":"Project Collabri for Treatment of Depression","status":"COMPLETED","sponsor":"Amager Hospital","startDate":"2014-11","conditions":"Depression","enrollment":325},{"nctId":"NCT02678624","phase":"NA","title":"Project Collabri for Treatment of Anxiety","status":"COMPLETED","sponsor":"Amager Hospital","startDate":"2014-11","conditions":"Generalized Anxiety, Social Phobia, Panic Disorder","enrollment":406},{"nctId":"NCT03113201","phase":"NA","title":"Collabri Flex - Effect of Collaborative Care for People With Depression in General Practice","status":"COMPLETED","sponsor":"Amager Hospital","startDate":"2018-01-15","conditions":"Depression","enrollment":389},{"nctId":"NCT06978127","phase":"NA","title":"Technology Assisted Collaborative Care Intervention to Improve Patient-centered Outcomes in Dialysis Patients","status":"RECRUITING","sponsor":"University of Pittsburgh","startDate":"2025-08-28","conditions":"Chronic Kidney Disease Requiring Hemodialysis","enrollment":424},{"nctId":"NCT06375135","phase":"NA","title":"Efficacy of mHealth + e-Navigator Stepped Care Intervention for ART Adherence Among Latino Men With HIV","status":"RECRUITING","sponsor":"Florida International University","startDate":"2024-06-06","conditions":"ART Adherence","enrollment":250},{"nctId":"NCT07377149","phase":"NA","title":"Improving the Quality of Coronary Artery Bypass Grafting","status":"NOT_YET_RECRUITING","sponsor":"China National Center for Cardiovascular Diseases","startDate":"2026-03-15","conditions":"Coronary Artery Bypass Grafting (CABG)","enrollment":8700},{"nctId":"NCT07375914","phase":"NA","title":"Comprehensive Biopsychosocial Approach for Acute Low Back Pain Management in the Emergency Department: a Stepped-wedge Cluster-randomized Clinical Trial","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2026-01-15","conditions":"Non-traumatic Low Back Pain","enrollment":782},{"nctId":"NCT07373405","phase":"NA","title":"Online Interventions to Prevent Alcohol Use Disorders","status":"NOT_YET_RECRUITING","sponsor":"University of Southern Denmark","startDate":"2026-02-01","conditions":"Alcohol Use Disorder (AUD)","enrollment":3519},{"nctId":"NCT04614168","phase":"NA","title":"Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes","status":"COMPLETED","sponsor":"University of Edinburgh","startDate":"2021-07-26","conditions":"Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia, Hypoglycemia","enrollment":24},{"nctId":"NCT06122688","phase":"NA","title":"By Youth, For Youth: Digital Supported Peer Navigation for Addressing Child Mental Health Care","status":"NOT_YET_RECRUITING","sponsor":"University of California, Riverside","startDate":"2026-07-01","conditions":"Anxiety, Depression, Mental Health Issue","enrollment":8360},{"nctId":"NCT07368660","phase":"NA","title":"InPART RX - Epicenters","status":"COMPLETED","sponsor":"Emory University","startDate":"2023-01-01","conditions":"Hospital Infection, Standardized Antibiotic Prescribing Ratio (SAR)","enrollment":169},{"nctId":"NCT07232901","phase":"NA","title":"Implementing Family Participation Training in Tertiary Hospital Care in Bangladesh","status":"COMPLETED","sponsor":"Michele van Vugt","startDate":"2025-08-09","conditions":"Family Participation in Hospital Care, Hospital Medicine, Training Family Caregivers","enrollment":1029},{"nctId":"NCT04593277","phase":"NA","title":"Interactive Survivorship Program for the Improvement of Healthcare Resources in Adolescent and Young Adult Cancer Survivors, INSPIRE-AYA Study","status":"COMPLETED","sponsor":"Fred Hutchinson Cancer Center","startDate":"2022-10-23","conditions":"Clinical Stage I Cutaneous Melanoma AJCC v8, Clinical Stage II Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Melanoma AJCC v8","enrollment":549},{"nctId":"NCT04574518","phase":"NA","title":"Teachable Moment to Opt-out of Tobacco: Interactive Voice Response Quit Line for Veteran Active Smokers With Lung Nodules","status":"ACTIVE_NOT_RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2022-08-12","conditions":"Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Tobacco Use","enrollment":223},{"nctId":"NCT06976710","phase":"NA","title":"PRIORITY-CONNECT 2 Trial","status":"RECRUITING","sponsor":"Surgical Outcomes Research Centre (SOuRCe)","startDate":"2025-10-15","conditions":"Colorectal Cancer, Colorectal Neoplasms","enrollment":564},{"nctId":"NCT05528224","phase":"NA","title":"Effect of SC-ICBT for Adults With OCD：A Three-Arm Randomized Controlled Trial","status":"TERMINATED","sponsor":"Shanghai Mental Health Center","startDate":"2022-09-01","conditions":"Obsessive-Compulsive Disorder","enrollment":46},{"nctId":"NCT07356492","phase":"NA","title":"Expanding Veteran Sponsorship Initiative+ to Support High-Risk Transitioning Servicemembers and Veterans: A Precision Medicine Approach","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2026-01-01","conditions":"Reintegration Difficulties, Suicidal Ideation and Behaviors, Health","enrollment":2700},{"nctId":"NCT07355348","phase":"NA","title":"Feasibility of a Cognitive Stepped Care Program for Adults With Brain Metastases","status":"RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2026-01-09","conditions":"Brain Metastases, Brain Metastasis","enrollment":140},{"nctId":"NCT07340983","phase":"NA","title":"Effectiveness of the Safe Haven Application (App) Among Undergraduates","status":"RECRUITING","sponsor":"National Cheng-Kung University Hospital","startDate":"2025-09-16","conditions":"Depression, Anxiety","enrollment":68},{"nctId":"NCT06720272","phase":"NA","title":"School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions","status":"RECRUITING","sponsor":"Thomas Pilgrim","startDate":"2024-12-15","conditions":"Rheumatic Heart Disease in Children","enrollment":6000},{"nctId":"NCT04514341","phase":"","title":"Implementing a Multilevel Intervention to Accelerate Colorectal Cancer Screening and Follow-up","status":"COMPLETED","sponsor":"Milton S. Hershey Medical Center","startDate":"2020-09-01","conditions":"Colorectal Cancer","enrollment":4},{"nctId":"NCT06659094","phase":"NA","title":"Reducing Maximal Support in OCD: Efficacy of Stepped-Care Online CBT","status":"COMPLETED","sponsor":"Shanghai Mental Health Center","startDate":"2023-08-21","conditions":"Obsessive Compulsive Disorder (OCD)","enrollment":95},{"nctId":"NCT07336550","phase":"NA","title":"Reduction of Low-value Prescribing Through Audit and Feedback","status":"NOT_YET_RECRUITING","sponsor":"Basque Health Service","startDate":"2026-02","conditions":"Inappropriate Prescribing, Implementation Science, Behavioral Sciences","enrollment":540},{"nctId":"NCT04350866","phase":"","title":"Enhancing Access to Insomnia (EASI) Care in VA PCMHI Clinics","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2021-02-01","conditions":"Chronic Insomnia","enrollment":277920},{"nctId":"NCT04601064","phase":"NA","title":"Peer Supported Collaborative Care Mental Health and Substance Use Disorder Care","status":"ACTIVE_NOT_RECRUITING","sponsor":"Johns Hopkins University","startDate":"2022-04-20","conditions":"HIV Infections, Substance Use Disorders, Mental Health Disorder","enrollment":405},{"nctId":"NCT06790641","phase":"NA","title":"Pathways to Perinatal Mental Health Equity","status":"RECRUITING","sponsor":"University of Massachusetts, Worcester","startDate":"2025-12-05","conditions":"Perinatal Anxiety, Perinatal Depression, Social Determinants of Health (SDOH)","enrollment":1270},{"nctId":"NCT05601206","phase":"NA","title":"Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE","status":"SUSPENDED","sponsor":"University of Pittsburgh","startDate":"2026-01-14","conditions":"Cancer, Depression, Fatigue","enrollment":40},{"nctId":"NCT07320703","phase":"NA","title":"\"Breathlessness Diagnostics in a Box\" (BiaB) for Primary Care. A Multi-country Quality Improvement Project Using a Randomized Stepped-wedge Design","status":"RECRUITING","sponsor":"General Practitioners Research Institute","startDate":"2024-08-05","conditions":"Breathlessness, Cardiovascular, Pulmonary","enrollment":900},{"nctId":"NCT07321171","phase":"NA","title":"Stepped-Care for Suicidal Youth and Children","status":"RECRUITING","sponsor":"Shira Barzilay","startDate":"2024-05-07","conditions":"Suicidal Ideation and Behavior","enrollment":350},{"nctId":"NCT05735314","phase":"NA","title":"A New Combination of Evidence-Based Interventions to Improve Primary Care Diagnostic Safety and Efficiency","status":"RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2024-01-08","conditions":"Anemia, Decreased Glomerular Filtration Rate","enrollment":450},{"nctId":"NCT05923983","phase":"NA","title":"DETECT-IP: a Clinical Decision Support System and Intelligent Procedures to Counter Some Adverse Drug Events in Older Hospital Patients","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2023-10-02","conditions":"Patient Acceptance of Health Care, Acute Renal Failure","enrollment":783},{"nctId":"NCT05747443","phase":"NA","title":"Multilevel Interventions to Increase Adherence to Lung Cancer Screening","status":"ACTIVE_NOT_RECRUITING","sponsor":"Kaiser Permanente","startDate":"2022-12-12","conditions":"Lung Cancer, Lung Cancer Screening","enrollment":1837},{"nctId":"NCT05284513","phase":"NA","title":"Collaborative Approach to Reach Everyone With Familial Hypercholesterolemia (CARE-FH)","status":"ENROLLING_BY_INVITATION","sponsor":"Geisinger Clinic","startDate":"2022-09-09","conditions":"Familial Hypercholesterolemia","enrollment":532},{"nctId":"NCT03860168","phase":"NA","title":"PICU Up!: A Pilot Stepped-wedge Trial of a Multicomponent Early Mobility Intervention for Critically Ill Children","status":"ACTIVE_NOT_RECRUITING","sponsor":"Johns Hopkins University","startDate":"2019-04-01","conditions":"Critical Illness","enrollment":2500},{"nctId":"NCT02421133","phase":"NA","title":"Impact of a Transitional Care Program on 30-Day Hospital Readmissions for Elderly Patients Discharged From a Short Stay Geriatric Ward","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2015-07","conditions":"Geriatrics","enrollment":630},{"nctId":"NCT07016646","phase":"NA","title":"SH+ and Cash Assistance","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2025-06-20","conditions":"Stress, Depression Symptoms","enrollment":40},{"nctId":"NCT04491045","phase":"NA","title":"Implementation Strategies for Task-Shifting Depression Care Depression Care in Vietnam","status":"COMPLETED","sponsor":"City University of New York, School of Public Health","startDate":"2021-12-01","conditions":"Depression","enrollment":1382},{"nctId":"NCT07281820","phase":"NA","title":"FRAME - Implementation of a PRO Measure to Inform Patient-Centered Survivorship Care in Oncology Outpatient Visits","status":"RECRUITING","sponsor":"Vejle Hospital","startDate":"2025-03-01","conditions":"Cancer, Late Effects","enrollment":30},{"nctId":"NCT06640803","phase":"NA","title":"Sacramento Clinical High Risk for Psychosis Stepped-Care Program","status":"RECRUITING","sponsor":"University of California, Davis","startDate":"2023-03-20","conditions":"Clinical High Risk for Psychosis, Ultra High Risk for Psychosis","enrollment":223},{"nctId":"NCT05793151","phase":"NA","title":"Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy","status":"RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2023-10-30","conditions":"Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Oropharynx Cancer","enrollment":532},{"nctId":"NCT06973655","phase":"NA","title":"Trial of Social Work Services in Fracture Clinic Setting","status":"RECRUITING","sponsor":"Sheila Sprague","startDate":"2025-10-06","conditions":"Orthopaedic Fractures, Socioeconomic Factors","enrollment":2000},{"nctId":"NCT06456307","phase":"NA","title":"Integration of Stepped Care for Perinatal Mood and Anxiety Disorders Among Women Attending MCH Clinics","status":"RECRUITING","sponsor":"Kenyatta National Hospital","startDate":"2025-02-17","conditions":"Depression, Anxiety, Antenatal Depression, Postnatal Depression","enrollment":2970},{"nctId":"NCT06845345","phase":"PHASE4","title":"Effect of Mediterranean Diet Combined With Intermittent Fasting on Liver Fibrosis Compared to Naltrexone/Bupropion in People With Cardiometabolic Risk Factors (MEDFAST-study)","status":"ENROLLING_BY_INVITATION","sponsor":"Carmen Dietvorst","startDate":"2025-04-14","conditions":"Diabetes Mellitus, Type 2, Liver Fibrosis, Liver Steatoses","enrollment":70},{"nctId":"NCT07210905","phase":"NA","title":"Implementation of the 3-steps Assess-Advise-Refer Exercise (FitARise) Protocol as a Standard Practice in Cancer Care","status":"NOT_YET_RECRUITING","sponsor":"The University of Hong Kong","startDate":"2025-12-01","conditions":"Exercise, Cancer","enrollment":1800},{"nctId":"NCT06967324","phase":"NA","title":"GRACE - Graduated Response for Advanced COPD With Enhanced Support","status":"RECRUITING","sponsor":"Copenhagen University Hospital, Hvidovre","startDate":"2025-08-07","conditions":"COPD (Chronic Obstructive Pulmonary Disease)","enrollment":100},{"nctId":"NCT05327166","phase":"NA","title":"The Emergency Department Longitudinal Integrated Care","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Washington","startDate":"2022-04-12","conditions":"Opioid Use Disorder","enrollment":500},{"nctId":"NCT06315842","phase":"NA","title":"Levels of Diagnostic and Therapeutic Intervention in Hospitalized Patients","status":"NOT_YET_RECRUITING","sponsor":"Consorci Sanitari de l'Alt Penedès i Garraf","startDate":"2026-02","conditions":"Acute Disease","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2109,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Optimized analgesics with collaborative care management"],"phase":"phase_3","status":"active","brandName":"Stepped care","genericName":"Stepped care","companyName":"US Department of Veterans Affairs","companyId":"us-department-of-veterans-affairs","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Stepped care is a treatment approach that involves a gradual escalation of interventions based on patient response. Used for Major depressive disorder, Anxiety disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}