{"id":"start-cozaar","brandName":"start cozaar","genericName":"start cozaar","companyId":"university-of-pittsburgh","companyName":"University of Pittsburgh","phase":"marketed","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Losartan, an angiotensin II receptor blocker (ARB), is primarily used to treat hypertension and heart failure. It has shown promise in reducing fibrosis and improving outcomes in various conditions, including pancreatic cancer and osteoarthritis. Despite no FDA label for Cozaar, it is widely prescribed off-label for its anti-fibrotic properties.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Losartan is an angiotensin II receptor antagonist (ARB) that selectively blocks the AT1 receptor subtype. By preventing angiotensin II from binding to these receptors, it prevents vasoconstriction and aldosterone secretion, leading to reduced peripheral vascular resistance and lower blood pressure. This mechanism also provides renal protection and reduces left ventricular hypertrophy.","oneSentence":"Cozaar (losartan) blocks angiotensin II receptors on blood vessels and tissues, causing vasodilation and reducing blood pressure.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"7-10","effect":"Dizziness"},{"rate":"3-5","effect":"Fatigue"},{"rate":"2-4","effect":"Hyperkalemia"},{"rate":"1-2","effect":"Cough"},{"rate":"5-7","effect":"Headache"}]},"trials":[],"indications":{"approved":[{"name":"Hypertension"},{"name":"Diabetic nephropathy in patients with type 2 diabetes"},{"name":"Heart failure with reduced ejection fraction"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}