{"id":"standard-opioid-plus-methocarbamol","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness/sedation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Lightheadedness"}]},"_chembl":{"chemblId":"CHEMBL1201117","moleculeType":"Small molecule","molecularWeight":"241.24"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The opioid component acts as a mu-opioid receptor agonist to reduce pain perception centrally, while methocarbamol is a central-acting muscle relaxant that depresses polysynaptic reflexes in the spinal cord and brainstem. Together, they provide complementary analgesic and muscle-relaxing effects for conditions involving both pain and muscle spasm.","oneSentence":"This combination product pairs an opioid analgesic with methocarbamol, a skeletal muscle relaxant, to provide pain relief and reduce muscle tension.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:09:31.144Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute musculoskeletal pain with muscle spasm"}]},"trialDetails":[{"nctId":"NCT05388929","phase":"PHASE4","title":"Methocarbamol in Ventral and Inguinal HR","status":"ACTIVE_NOT_RECRUITING","sponsor":"Prisma Health-Upstate","startDate":"2022-06-23","conditions":"Ventral Hernia, Inguinal Hernia","enrollment":164},{"nctId":"NCT04990804","phase":"PHASE4","title":"Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery","status":"TERMINATED","sponsor":"Vanderbilt University Medical Center","startDate":"2021-08-01","conditions":"Opioid Use, Spinal Diseases, Surgery--Complications","enrollment":8},{"nctId":"NCT02432456","phase":"PHASE4","title":"Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients","status":"COMPLETED","sponsor":"Medical College of Wisconsin","startDate":"2015-09","conditions":"Wounds and Injuries, Rib Fractures","enrollment":153}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Standard opioid plus methocarbamol","genericName":"Standard opioid plus methocarbamol","companyName":"Prisma Health-Upstate","companyId":"prisma-health-upstate","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methocarbamol is a small molecule that inhibits carbonic anhydrase I, a verified mechanism of action according to ChEMBL. Methocarbamol is being studied in combination with standard opioids for various conditions, including ventral and inguinal hernias, as well as opioid use and spinal diseases, in a prospective, randomized pilot study (NCT05388929).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}