{"id":"standard-of-care-methylprednisolone-acetate","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Osteoporosis (with chronic use)"},{"rate":null,"effect":"Immunosuppression/increased infection risk"},{"rate":null,"effect":"Mood changes, insomnia"},{"rate":null,"effect":"Adrenal suppression (with prolonged use)"},{"rate":null,"effect":"Local injection site reactions (if injected)"}]},"_chembl":null,"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Standard of Care: Methylprednisolone acetate","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:11:40.225566+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:11:47.256266+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Standard of Care: Methylprednisolone acetate","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:11:47.999310+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Glucocorticoid receptor agonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:12:01.050035+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1364144/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:12:00.956216+00:00"}},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methylprednisolone acetate works by entering cells and binding to intracellular glucocorticoid receptors, which then translocate to the nucleus and modulate gene expression. This leads to decreased production of pro-inflammatory cytokines, reduced immune cell activation and proliferation, and suppression of inflammatory mediators. The acetate ester formulation provides sustained release, making it suitable for depot injections.","oneSentence":"Methylprednisolone acetate is a synthetic corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:09:24.868Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:12:02.811600+00:00","fieldsConflicting":0,"overallConfidence":0.95},"indications":{"approved":[{"name":"Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis)"},{"name":"Allergic and dermatologic conditions"},{"name":"Respiratory inflammatory conditions"},{"name":"Intra-articular and soft tissue injection for localized inflammation"}]},"trialDetails":[{"nctId":"NCT05675410","phase":"PHASE3","title":"A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2023-05-11","conditions":"Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8","enrollment":1875},{"nctId":"NCT06235567","phase":"PHASE1, PHASE2","title":"Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking","status":"ENROLLING_BY_INVITATION","sponsor":"Maanasa Indaram, MD","startDate":"2025-04-11","conditions":"Keratoconus","enrollment":20},{"nctId":"NCT07472309","phase":"","title":"Effectiveness and Safety of Upadacitinib for Acute Severe Ulcerative Colitis","status":"COMPLETED","sponsor":"Xijing Hospital of Digestive Diseases","startDate":"2023-06-06","conditions":"Ulcerative Colitis (UC), Acute Severe Ulcerative Colitis, Upadacitinib","enrollment":81},{"nctId":"NCT07340463","phase":"PHASE2","title":"The Efficacy and Safety of Biologics (Belimumab/ Telitacicept) Induction Therapy in Proliferative Lupus Nephritis Patients for 6 Months Compared With Mycophenolate Mofetil Treatment","status":"RECRUITING","sponsor":"Nanjing University School of Medicine","startDate":"2025-12-08","conditions":"Systemic Lupus Erythematosus (SLE), Lupus Nephritis (LN)","enrollment":50},{"nctId":"NCT07461961","phase":"PHASE2","title":"CORTISHOCK-P: Trial of Corticosteroids in Inflammation-Enriched Heart Failure Cardiogenic Shock","status":"NOT_YET_RECRUITING","sponsor":"Brigham and Women's Hospital","startDate":"2026-07-01","conditions":"Cardiogenic Shock, Heart Failure, Inflammation","enrollment":30},{"nctId":"NCT04862221","phase":"PHASE2","title":"TReatment for ImmUne Mediated PathopHysiology","status":"RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2022-02-09","conditions":"Acute Liver Failure, Fulminant Hepatic Failure, Hepatic Encephalopathy","enrollment":163},{"nctId":"NCT06780202","phase":"PHASE2","title":"Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients","status":"RECRUITING","sponsor":"Emory University","startDate":"2025-01-27","conditions":"Foot Injuries and Disorders, Ankle Injuries and Disorders, Achilles Tendon Injury","enrollment":180},{"nctId":"NCT05800366","phase":"PHASE2","title":"A Phase II Study of Glofitamab Plus Polatuzumab-R-CHP for Patients With High-risk Diffuse Large B-cell Lymphoma","status":"RECRUITING","sponsor":"Jennifer Crombie, MD","startDate":"2023-04-06","conditions":"Lymphoma, Lymphoma, Large B-Cell, Diffuse","enrollment":41},{"nctId":"NCT05789589","phase":"PHASE1, PHASE2","title":"Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases","status":"RECRUITING","sponsor":"Baptist Health South Florida","startDate":"2023-11-17","conditions":"Cancer, Metastasis, Metastatic Cancer","enrollment":46},{"nctId":"NCT03644667","phase":"PHASE2","title":"Tocilizumab in Cardiac Transplantation","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2018-12-20","conditions":"Heart Transplant","enrollment":385},{"nctId":"NCT04977427","phase":"PHASE4","title":"Dextenza vs Prednisolone Acetate After Cataract Surgery for Patients With Diabetes","status":"WITHDRAWN","sponsor":"Baylor Research Institute","startDate":"2021-08-31","conditions":"Cataract Diabetic, Macula Edema","enrollment":""},{"nctId":"NCT05626478","phase":"PHASE4","title":"Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract Surgery","status":"COMPLETED","sponsor":"Nicole Fram M.D.","startDate":"2023-06-01","conditions":"Corneal Edema, Corneal Defect, Anterior Chamber Inflammation","enrollment":50},{"nctId":"NCT07268248","phase":"NA","title":"1-hour Premedication for Allergy Goal in Emergency: PAGE-1 Study","status":"NOT_YET_RECRUITING","sponsor":"Paul Peng, MD PhD MSCR","startDate":"2026-06","conditions":"Allergic Reaction to Contrast Media, Hypersensitivity Reaction, Computed Tomography","enrollment":540},{"nctId":"NCT07217405","phase":"PHASE4","title":"Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2025-12-19","conditions":"Osteoarthritis Hand, Osteoarthritis Wrist","enrollment":165},{"nctId":"NCT04371445","phase":"PHASE4","title":"Dextenza in the Post-op Management of Vitreoretinal Surgeries","status":"RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2020-06-01","conditions":"Vitreoretinal Surgery, Ocular Inflammation, Post-operative Pain","enrollment":30},{"nctId":"NCT07077486","phase":"PHASE4","title":"Effects of Telitacicept vs Cyclophosphamide on Lupus Related Interstitial Lung Disease","status":"RECRUITING","sponsor":"Tongji Hospital","startDate":"2025-08-25","conditions":"Lupus or SLE, Interstitial Lung Disease, Systemic Lupus Erythematosus","enrollment":100},{"nctId":"NCT07357935","phase":"PHASE1, PHASE2","title":"Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia","status":"NOT_YET_RECRUITING","sponsor":"Qingyuan Zhan","startDate":"2026-02-01","conditions":"Acute Respiratory Failure, Community-Acquired Pneumonia","enrollment":500},{"nctId":"NCT07152600","phase":"PHASE3","title":"Adaptive RCT of Corticosteroids for Severe Adenovirus Pneumonia in Adults","status":"NOT_YET_RECRUITING","sponsor":"Qingyuan Zhan","startDate":"2026-02-01","conditions":"Adenovirus Infections, Human","enrollment":262},{"nctId":"NCT07352865","phase":"PHASE3","title":"Adaptive RCT of Corticosteroids for Severe Chlamydia Psittaci Pneumonia in Adults","status":"NOT_YET_RECRUITING","sponsor":"Qingyuan Zhan","startDate":"2026-01-15","conditions":"Psittacosis","enrollment":100},{"nctId":"NCT07353749","phase":"PHASE4","title":"Efficacy and Safety of Methylprednisolone After Flow-Diverter Stent Implantation in Unruptured Intracranial Aneurysms","status":"NOT_YET_RECRUITING","sponsor":"Duan Chuanzhi","startDate":"2026-01-30","conditions":"Unruptured Intracranial Aneurysms, Cerebrovascular Event, Hemorrhagic Stroke","enrollment":864},{"nctId":"NCT07351500","phase":"PHASE3","title":"Adaptive RCT of Corticosteroids for Severe Influenza Pneumonia in Adults","status":"NOT_YET_RECRUITING","sponsor":"Qingyuan Zhan","startDate":"2026-01-15","conditions":"Influenza","enrollment":496},{"nctId":"NCT07348627","phase":"PHASE3","title":"Opioid-Sparing Joint Replacement","status":"NOT_YET_RECRUITING","sponsor":"Emory University","startDate":"2026-02","conditions":"Pain Management, Opioid Consumption","enrollment":120},{"nctId":"NCT06809998","phase":"PHASE1, PHASE2","title":"COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty","status":"RECRUITING","sponsor":"Unity Health Toronto","startDate":"2025-01-24","conditions":"Total Knee Anthroplasty, Osteoarthritis(Primary), Osteoarthritis (OA) of the Knee","enrollment":60},{"nctId":"NCT03391466","phase":"PHASE3","title":"Study of Effectiveness of Axicabtagene Ciloleucel Compared to Standard of Care Therapy in Patients With Relapsed/Refractory Diffuse Large B Cell Lymphoma","status":"COMPLETED","sponsor":"Kite, A Gilead Company","startDate":"2018-01-25","conditions":"Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)","enrollment":359},{"nctId":"NCT04873583","phase":"PHASE3","title":"High Dose Steroids in Children With Stroke","status":"RECRUITING","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2021-11-16","conditions":"Paediatric Stroke","enrollment":70},{"nctId":"NCT03933631","phase":"PHASE3","title":"Pilocarpine Use After Kahook Goniotomy","status":"RECRUITING","sponsor":"Montefiore Medical Center","startDate":"2019-05-01","conditions":"Glaucoma","enrollment":142},{"nctId":"NCT02283996","phase":"PHASE4","title":"Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2014-11","conditions":"Adhesive Capsulitis, Frozen Shoulder, Shoulder Frozen","enrollment":260},{"nctId":"NCT07049172","phase":"NA","title":"Rituximab and Targeted Nursing for Pediatric Nephrotic Syndrome","status":"COMPLETED","sponsor":"Wuhan Children's Hospital","startDate":"2021-01-01","conditions":"Nephrotic Syndrome in Children","enrollment":91},{"nctId":"NCT06320067","phase":"PHASE3","title":"A Randomised Controlled Platform Trial Testing Treatments in Metastatic Hormone Sensitive Prostate Cancer","status":"RECRUITING","sponsor":"University College, London","startDate":"2024-06-11","conditions":"Prostate Cancer Metastatic","enrollment":3360},{"nctId":"NCT04074187","phase":"PHASE2, PHASE3","title":"A Trial of Caplacizumab in Japanese Patients With Acquired Thrombotic Thrombocytopenic Purpura (aTTP)","status":"COMPLETED","sponsor":"Sanofi","startDate":"2019-10-21","conditions":"Thrombotic Thrombocytopenic Purpura","enrollment":21},{"nctId":"NCT05859269","phase":"PHASE4","title":"Methylprednisolone Taper After Total Knee Replacement","status":"COMPLETED","sponsor":"Emory University","startDate":"2023-10-16","conditions":"Knee Arthritis","enrollment":101},{"nctId":"NCT05480566","phase":"NA","title":"Functional Strength Training and Neuromuscular Electrical Stimulation in Severe Acute Exacerbations of COPD","status":"TERMINATED","sponsor":"Hasselt University","startDate":"2022-06-01","conditions":"Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Exacerbation of COPD","enrollment":35},{"nctId":"NCT07152613","phase":"PHASE3","title":"Corticosteroids for PJP in Non-HIV Immunocompromised Adults","status":"NOT_YET_RECRUITING","sponsor":"Qingyuan Zhan","startDate":"2025-09-08","conditions":"Pneumocystis Jiroveci Pneumonia","enrollment":240},{"nctId":"NCT07152587","phase":"PHASE2, PHASE3","title":"Randomized Adaptive Platform Trial of Pathogen-Directed Anti-inflammatory Therapy in Severe Community-Acquired Pneumonia(Core Protocal)","status":"NOT_YET_RECRUITING","sponsor":"Qingyuan Zhan","startDate":"2025-09-08","conditions":"Severe Community-acquired Pneumonia (sCAP)","enrollment":1500},{"nctId":"NCT05023304","phase":"PHASE4","title":"In Clinic Optometrist Insertion of Dextenza Prior to Cataract Surgery","status":"COMPLETED","sponsor":"Vance Thompson Vision","startDate":"2021-08-23","conditions":"Cataract","enrollment":30},{"nctId":"NCT07098897","phase":"PHASE3","title":"To Evaluate the Effect and Safety of Telitacicept and Standard Treatment for 6months in IgA Nephropathy","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Affiliated Hospital of Xuzhou Medical University","startDate":"2024-08-01","conditions":"IgA Nephropathy (IgAN)","enrollment":150},{"nctId":"NCT05150704","phase":"PHASE3","title":"MYTHS - MYocarditis THerapy With Steroids","status":"RECRUITING","sponsor":"Niguarda Hospital","startDate":"2021-10-07","conditions":"Myocarditis Acute","enrollment":288},{"nctId":"NCT05929755","phase":"PHASE4","title":"Depo-Medrol on Psoas After LLIF","status":"RECRUITING","sponsor":"Hardeep Singh","startDate":"2023-05-12","conditions":"Muscle Weakness, Pain, Postoperative, Paresthesia","enrollment":80},{"nctId":"NCT05157113","phase":"PHASE4","title":"Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2022-05-31","conditions":"Cataract, Surgery, Compliance, Patient","enrollment":70},{"nctId":"NCT03456817","phase":"PHASE2","title":"HIgh Dose Thymoglobulin Instead of Cyclosporine With a Low Dose of Thymoglobulin for GVHD Prophylaxis","status":"TERMINATED","sponsor":"AHS Cancer Control Alberta","startDate":"2020-07-01","conditions":"Graft-versus-host-disease, Relapse","enrollment":68},{"nctId":"NCT07070882","phase":"PHASE1","title":"Oral Steroid Taper After Total Knee Arthroplasty","status":"RECRUITING","sponsor":"Columbia University","startDate":"2025-06-20","conditions":"Osteoarthritis, Knee","enrollment":130},{"nctId":"NCT06520345","phase":"PHASE3","title":"The Study of 177Lu-TLX591 Plus SOC Versus SOC Alone in Patients With mCRPC (ProstACT Global)","status":"RECRUITING","sponsor":"Telix Pharmaceuticals (Innovations) Pty Limited","startDate":"2024-07-26","conditions":"Metastatic Castration-resistant Prostate Cancer","enrollment":430},{"nctId":"NCT04372615","phase":"PHASE2","title":"The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis","status":"RECRUITING","sponsor":"University of Utah","startDate":"2022-03-30","conditions":"Autoimmune Encephalitis, Encephalitis","enrollment":116},{"nctId":"NCT05331664","phase":"PHASE4","title":"Dropless Pars Plana Vitrectomy Study","status":"RECRUITING","sponsor":"Massachusetts Eye and Ear Infirmary","startDate":"2022-07-25","conditions":"Rhegmatogenous Retinal Detachment","enrollment":168},{"nctId":"NCT04351737","phase":"PHASE4","title":"Dextenza for Post-operative Treatment of Pterygium","status":"COMPLETED","sponsor":"Brandon Eye Associates, PA","startDate":"2020-07-15","conditions":"Pterygium of Both Eyes","enrollment":20},{"nctId":"NCT05279092","phase":"PHASE2","title":"Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study","status":"RECRUITING","sponsor":"Yale University","startDate":"2022-09-08","conditions":"Total Knee Replacement, Knee Arthroplasty","enrollment":250},{"nctId":"NCT05974462","phase":"PHASE3","title":"MYTHS-MR Trial (MYocarditis THerapy With Steroids in Patients With Mildly Reduced Ejection Fraction)","status":"RECRUITING","sponsor":"University Hospital, Antwerp","startDate":"2024-05-24","conditions":"Acute Myocarditis","enrollment":174},{"nctId":"NCT03994783","phase":"PHASE3","title":"Transplant Antibody-Mediated Rejection: Guiding Effective Treatments","status":"TERMINATED","sponsor":"Imperial College London","startDate":"2019-07-17","conditions":"Kidney Transplant Rejection, Antibody-mediated Rejection","enrollment":3},{"nctId":"NCT06916650","phase":"NA","title":"Comparing HILT, Steroid Injection, and Manual Therapy for Frozen Shoulder","status":"RECRUITING","sponsor":"Al Hayah University In Cairo","startDate":"2025-04-25","conditions":"Frozen Shoulder","enrollment":180},{"nctId":"NCT05545384","phase":"PHASE3","title":"Immediate Versus Delayed Treatment With Azathioprine or Rituximab in Anti-MOG Antibodies Associated Acute Demyelinating Syndromes in Children: a Randomized Controlled Clinical Trial","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2025-04","conditions":"Acute Demyelinating Syndrome","enrollment":86},{"nctId":"NCT05401812","phase":"PHASE2","title":"Glucocorticoid Therapy for Acute Respiratory Distress Syndrome","status":"WITHDRAWN","sponsor":"National Taiwan University Hospital","startDate":"2022-07-01","conditions":"Acute Respiratory Distress Syndrome","enrollment":""},{"nctId":"NCT06229964","phase":"NA","title":"Frozen Shoulder Treatment with Intra-Articular Corticosteroid Injection and Suprascapular Nerve Block","status":"RECRUITING","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2025-02-01","conditions":"Frozen Shoulder, Adhesive Capsulitis","enrollment":100},{"nctId":"NCT05005637","phase":"PHASE2","title":"The Effectivity of Anti Tuberculosis Therapy in Idiopathic Uveitis with Positive IGRA","status":"COMPLETED","sponsor":"Fakultas Kedokteran Universitas Indonesia","startDate":"2021-08-27","conditions":"Tuberculous Uveitis","enrollment":78},{"nctId":"NCT06768294","phase":"PHASE2","title":"Baricitinib in CPPD - the BAPTIST Study","status":"NOT_YET_RECRUITING","sponsor":"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio","startDate":"2025-01","conditions":"Calcium Pyrophosphate Deposition Disease, Chondrocalcinosis","enrollment":32},{"nctId":"NCT04826237","phase":"PHASE4","title":"Oral Statins and Protection From Hearing Loss","status":"RECRUITING","sponsor":"Northwestern University","startDate":"2023-02-09","conditions":"Sudden Sensorineural Hearing Loss","enrollment":100},{"nctId":"NCT06681688","phase":"PHASE1, PHASE2","title":"Study of Complication Rates in Cataract Surgery Patients Treated With Combined Pre-operative NSAID, OMIDRIA, and Subconjunctival Triamcinolone Acetonide Compared With Peri-operative SOC","status":"RECRUITING","sponsor":"Inder Paul Singh, M.D.","startDate":"2024-07-10","conditions":"Cataract","enrollment":94},{"nctId":"NCT05714670","phase":"PHASE2","title":"The Effect of Curcumin on the Clinical Outcome of Pediatric Patients with Active Lupus Nephritis","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2023-04-01","conditions":"Lupus Nephritis, SLE Nephritis","enrollment":72},{"nctId":"NCT03586999","phase":"PHASE1, PHASE2","title":"Nivolumab With Standard of Care Chemotherapy for Peripheral T Cell Lymphomas","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2018-11-07","conditions":"Peripheral T Cell Lymphoma","enrollment":18},{"nctId":"NCT06656962","phase":"PHASE1, PHASE2","title":"The Efficacy and Safety of Treatment with Telitacicept in Antineutrophil Cytoplasmic Antibody-associated Nephritis (AAGN)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Renmin Hospital of Wuhan University","startDate":"2024-10-10","conditions":"Antineutrophil Cytoplasmic Antibody (ANCA)-associated Nephritis (AAGN)","enrollment":15},{"nctId":"NCT03747159","phase":"PHASE3","title":"Synergetic B-cell Immunomodulation in SLE - 2nd Study.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Leiden University Medical Center","startDate":"2018-10-01","conditions":"Lupus Erythematosus, Systemic","enrollment":70},{"nctId":"NCT04396990","phase":"PHASE4","title":"The RESTORE Study, A Randomized, Controlled, Masked (Reading Center) Prospective Study","status":"COMPLETED","sponsor":"Vance Thompson Vision","startDate":"2020-06-08","conditions":"Refractive Surgery","enrollment":20},{"nctId":"NCT02867800","phase":"PHASE1","title":"Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease","status":"COMPLETED","sponsor":"Monica Bhatia","startDate":"2016-07","conditions":"Sickle Cell Disease, Graft Versus Host Disease","enrollment":24},{"nctId":"NCT02061800","phase":"PHASE1, PHASE2","title":"CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant","status":"ACTIVE_NOT_RECRUITING","sponsor":"Diane George","startDate":"2013-06-03","conditions":"Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML), Myelodysplastic Syndrome (MDS)","enrollment":14},{"nctId":"NCT05848427","phase":"","title":"The LUSZ COVID-19 Severity Index: A Prognostic and Predictive Score of Mortality for Hospitalized Patients With Covid-19","status":"RECRUITING","sponsor":"Lebanese University","startDate":"2020-03-28","conditions":"COVID-19","enrollment":1000},{"nctId":"NCT03900624","phase":"PHASE4","title":"Ideal Steroids for Asthma Treatment in the PICU","status":"COMPLETED","sponsor":"Johns Hopkins All Children's Hospital","startDate":"2019-04-21","conditions":"Asthma Childhood","enrollment":92},{"nctId":"NCT04200651","phase":"PHASE4","title":"Prospective Study on DEXTENZA® Safety And Efficacy Following Concomitant MIGS and Cataract Surgery","status":"TERMINATED","sponsor":"The New York Eye Surgery Center","startDate":"2020-01-13","conditions":"Glaucoma, Cataract","enrollment":25},{"nctId":"NCT06223984","phase":"PHASE4","title":"Combined Use of Immunoglobulin and Pulse Steroid Therapies in Severe Covid-19 Patients","status":"COMPLETED","sponsor":"Konya City Hospital","startDate":"2020-03-30","conditions":"Pulse Steroid and Immunoglobulins Drugs in Covid 19 Patients","enrollment":178},{"nctId":"NCT06221345","phase":"PHASE4","title":"Hyaluronic Acid-containing Artificial Tears in Post-cataract Surgery Dry Eye Disease","status":"COMPLETED","sponsor":"Chang Gung Memorial Hospital","startDate":"2021-12-07","conditions":"Dry Eye Disease, Cataract","enrollment":70},{"nctId":"NCT05655130","phase":"PHASE1","title":"Distal Radius Steroid","status":"TERMINATED","sponsor":"Indiana Hand to Shoulder Center","startDate":"2018-11-06","conditions":"Fractures, Bone, Fractures, Closed, Radius Fracture Distal","enrollment":30},{"nctId":"NCT03371667","phase":"PHASE3","title":"To Compare the Efficacy of the Addition of Methotrexate (MTX) to Current Standard Acute Graft-versus-host Disease (GVHD) First-line Treatment With Corticosteroids","status":"UNKNOWN","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2018-08-16","conditions":"Allogeneic Disease, GVH - Graft Versus Host Reaction, GVHD, Acute","enrollment":102},{"nctId":"NCT06211920","phase":"NA","title":"Prehospital Non-invasive Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease","status":"UNKNOWN","sponsor":"Central Denmark Region","startDate":"2023-12-08","conditions":"COPD Exacerbation, COPD Exacerbation Acute, Noninvasive Ventilation","enrollment":140},{"nctId":"NCT04381936","phase":"PHASE3","title":"Randomised Evaluation of COVID-19 Therapy","status":"RECRUITING","sponsor":"University of Oxford","startDate":"2020-03-19","conditions":"Severe Acute Respiratory Syndrome","enrollment":70000},{"nctId":"NCT06163755","phase":"PHASE2","title":"Comparison of Efficacy of Intra-articular Morphine vs Methylprednisolone in Patients With Knee Osteoarthritis.","status":"WITHDRAWN","sponsor":"Henry Ford Health System","startDate":"2018-01-01","conditions":"Osteoarthritis, Knee","enrollment":""},{"nctId":"NCT04988282","phase":"PHASE4","title":"Systemic Corticosteroids in Treatment of Post-COVID-19 Interstitial Lung Disease","status":"COMPLETED","sponsor":"Turkish Thoracic Society","startDate":"2021-05-24","conditions":"Covid19, COVID-19 Pneumonia, Interstitial Lung Disease","enrollment":262},{"nctId":"NCT04380857","phase":"PHASE4","title":"Assessing Dextenza Insert After SMILE Procedure","status":"COMPLETED","sponsor":"William Wiley, MD","startDate":"2020-06-18","conditions":"Post Procedural Infection","enrollment":20},{"nctId":"NCT01431326","phase":"","title":"Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care","status":"COMPLETED","sponsor":"Daniel Benjamin","startDate":"2011-11","conditions":"Adenovirus, Anesthesia, Anxiety","enrollment":3520},{"nctId":"NCT05947669","phase":"PHASE3","title":"Efficacy and Safety of Infliximab for Immune Checkpoint Inhibitor Induced Colitis","status":"RECRUITING","sponsor":"Odense University Hospital","startDate":"2023-08-22","conditions":"Colitis","enrollment":195},{"nctId":"NCT05855395","phase":"NA","title":"The Standard of Care Combined With Glucocorticoid in Elderly People With Mild or Moderate COVID-19","status":"UNKNOWN","sponsor":"Huashan Hospital","startDate":"2023-05-26","conditions":"COVID-19","enrollment":5815},{"nctId":"NCT04462523","phase":"PHASE4","title":"DEXTENZA for the Treatment of Postoperative Pain and Inflammation Following Vitreo-retinal Surgery","status":"COMPLETED","sponsor":"Patrick R. Oellers, MD","startDate":"2020-01-03","conditions":"Vitreo-Retinal Surgery","enrollment":40},{"nctId":"NCT00268476","phase":"PHASE2, PHASE3","title":"Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Medical Research Council","startDate":"2005-07-08","conditions":"Prostate Cancer","enrollment":11992},{"nctId":"NCT04903054","phase":"PHASE2","title":"Selective CD28 Blockade in Renal Transplant Recipients","status":"WITHDRAWN","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2022-01-10","conditions":"Kidney Transplantation, Renal Transplant Recipients","enrollment":""},{"nctId":"NCT01086540","phase":"PHASE2","title":"Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2011-06-24","conditions":"Systemic Sclerosis-Associated PAH","enrollment":57},{"nctId":"NCT05187793","phase":"PHASE3","title":"Study of Efficacy of Different Treatment Regimens of Olokizumab","status":"UNKNOWN","sponsor":"R-Pharm","startDate":"2021-07-08","conditions":"COVID-19","enrollment":198},{"nctId":"NCT03917797","phase":"PHASE2","title":"Mesenchymal Stromal Cells (MSC´s) in Renal Lupus","status":"UNKNOWN","sponsor":"Universidad de los Andes, Chile","startDate":"2019-04-02","conditions":"Lupus Erythematosus, Systemic, Lupus Glomerulonephritis","enrollment":39},{"nctId":"NCT02213068","phase":"PHASE4","title":"Belatacept 3 Month Post Transplant Conversion Study","status":"COMPLETED","sponsor":"Lorenzo Gallon","startDate":"2014-07","conditions":"Transplant; Failure, Kidney, EBV","enrollment":28},{"nctId":"NCT03388008","phase":"PHASE2","title":"Belatacept Pilot Study in Lung Transplantation Immunosuppression in Lung Transplantation","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2019-12-17","conditions":"Lung Transplant Rejection, Antibody-mediated Rejection","enrollment":27},{"nctId":"NCT03249844","phase":"PHASE3","title":"Paediatric Arteriopathy Steroid Aspirin Project","status":"WITHDRAWN","sponsor":"Centre Hospitalier Universitaire de Saint Etienne","startDate":"2022-09-01","conditions":"Arterial Ischemic Stroke","enrollment":""},{"nctId":"NCT04921033","phase":"PHASE3","title":"Exclusive Enteral Nutrition in Patients With Ileocaecal Crohn's Disease","status":"UNKNOWN","sponsor":"Duzce University","startDate":"2021-03-01","conditions":"Crohn Disease, Nutrient; Excess, Remission/Regression","enrollment":256},{"nctId":"NCT03977454","phase":"PHASE2","title":"Periarticular Injection Versus Peripheral Nerve Block in Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Yale University","startDate":"2019-11-11","conditions":"Hip Arthropathy","enrollment":192},{"nctId":"NCT05248139","phase":"NA","title":"Safety and Effectiveness of Drop-free Small Incision Cataract Surgery","status":"UNKNOWN","sponsor":"Visualiza","startDate":"2022-10","conditions":"Cataract, Ocular Inflammation, Ocular Hypertension","enrollment":100},{"nctId":"NCT04874610","phase":"","title":"Steroid Metabolism in Obese and Non-Obese Pediatric Patients Hospitalized for Status Asthmaticus","status":"COMPLETED","sponsor":"Duke University","startDate":"2021-08-16","conditions":"Pediatric Obesity, Asthma in Children","enrollment":15},{"nctId":"NCT05422911","phase":"PHASE2","title":"Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.","status":"NOT_YET_RECRUITING","sponsor":"James J. Peters Veterans Affairs Medical Center","startDate":"2022-06-30","conditions":"Metastatic Cancer, Neoplasm, Prostate","enrollment":200},{"nctId":"NCT05417997","phase":"PHASE3","title":"Effect of Kunamin in SARS-CoV-2 RT-PCR Positive Covid-19 Patients","status":"COMPLETED","sponsor":"RAAS Nutritionals, LLC","startDate":"2021-05-29","conditions":"COVID-19 Respiratory Infection, FLU, Cold; Influenza","enrollment":71},{"nctId":"NCT03578276","phase":"PHASE4","title":"Prophylactic Treatment: Lessdrops™ vs Standard Drops Regimen","status":"COMPLETED","sponsor":"Carolina Eyecare Physicians, LLC","startDate":"2018-06-22","conditions":"Cataract","enrollment":35},{"nctId":"NCT04320836","phase":"","title":"Non-organic Signs to Predict Outcomes for Neck Pain","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2020-06-15","conditions":"Cervical Radiculopathy, Cervical Radicular Pain","enrollment":78},{"nctId":"NCT04977960","phase":"PHASE2","title":"Efficacy of Canrenone as add-on Treatment in Moderate to Severe ARDS in COVID-19","status":"UNKNOWN","sponsor":"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","startDate":"2022-09","conditions":"COVID-19 Acute Respiratory Distress Syndrome","enrollment":180},{"nctId":"NCT04016025","phase":"PHASE4","title":"A Clinical Study of Adherence to Methylprednisolone Aceponate in Different Carriers","status":"COMPLETED","sponsor":"Jena University Hospital","startDate":"2020-12-02","conditions":"Adherence, Patient, Chronic Eczema","enrollment":80},{"nctId":"NCT04005079","phase":"PHASE3","title":"Pilocarpine After Combined Cataract/Trabectome Surgery","status":"WITHDRAWN","sponsor":"Montefiore Medical Center","startDate":"2019-06-05","conditions":"Open Angle Glaucoma, Ocular Hypertension","enrollment":""},{"nctId":"NCT05279482","phase":"","title":"Comparison Between Different Doses of Steroids in COVID-19 Patients","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2022-01-19","conditions":"Critical Illness, Pneumonia, Viral","enrollment":104},{"nctId":"NCT01085097","phase":"PHASE2","title":"A Study of Laquinimod in Participants With Systemic Lupus Erythematosus (SLE) Active Lupus Nephritis","status":"COMPLETED","sponsor":"Teva Branded Pharmaceutical Products R&D, Inc.","startDate":"2010-09-01","conditions":"Lupus Nephritis","enrollment":46}],"_emaApprovals":[],"_faersSignals":[],"crossReferences":{"chemblId":"CHEMBL1364144"},"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Standard of Care: Methylprednisolone acetate","genericName":"Standard of Care: Methylprednisolone acetate","companyName":"Herbert Lindsley, MD","companyId":"herbert-lindsley-md","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methylprednisolone acetate is a synthetic corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors. Used for Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis), Allergic and dermatologic conditions, Respiratory inflammatory conditions.","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:12:02.811600+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}