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This reduces circulating blood volume and extracellular fluid, decreasing cardiac preload and peripheral vascular resistance, which lowers blood pressure and alleviates symptoms of edema and congestion in heart failure and hypertension.","oneSentence":"Standard diuretic therapy reduces fluid volume in the body by increasing urinary sodium and water excretion, thereby lowering blood pressure and reducing fluid overload.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:09:23.153Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Heart failure with fluid overload"},{"name":"Edema associated with renal or hepatic disease"},{"name":"Pulmonary edema"}]},"trialDetails":[{"nctId":"NCT07369856","phase":"NA","title":"Spot Analysis of Natriuresis to Guide up- or Down-titration of Diuretic Therapy in Ambulatory Patients With Chronic Heart Failure","status":"RECRUITING","sponsor":"Cardiology Research 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