{"id":"standard-heart-failure-therapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Bradycardia"}]},"_chembl":{"chemblId":"CHEMBL261657","moleculeType":"Small molecule","molecularWeight":"405.37"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Standard heart failure therapy encompasses multiple drug classes working synergistically: ACE inhibitors reduce afterload and prevent ventricular remodeling, beta-blockers decrease heart rate and contractility to reduce oxygen demand, and diuretics manage fluid overload. This combination approach has been the cornerstone of heart failure management for decades, improving survival and symptom relief.","oneSentence":"Standard heart failure therapy typically refers to a combination of ACE inhibitors, beta-blockers, and diuretics that reduce cardiac workload, improve contractility, and manage fluid retention.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:09:15.106Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Heart failure with reduced ejection fraction (HFrEF)"},{"name":"Heart failure with preserved ejection fraction (HFpEF)"},{"name":"Symptomatic heart failure"}]},"trialDetails":[{"nctId":"NCT04282850","phase":"NA","title":"Ablation Versus Medical Management of Atrial Fibrillation in HFpEF","status":"TERMINATED","sponsor":"Inova Health Care Services","startDate":"2023-07-10","conditions":"Atrial Fibrillation, Heart Failure With Normal Ejection Fraction","enrollment":13},{"nctId":"NCT07369856","phase":"NA","title":"Spot Analysis of Natriuresis to Guide up- or Down-titration of Diuretic Therapy in Ambulatory Patients With Chronic Heart Failure","status":"RECRUITING","sponsor":"Cardiology Research UBC","startDate":"2025-11-04","conditions":"Heart Failure, Diuretics","enrollment":300},{"nctId":"NCT05677100","phase":"NA","title":"Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure","status":"RECRUITING","sponsor":"Procyrion","startDate":"2023-08-23","conditions":"Heart Failure, Cardiorenal Syndrome, Cardio-Renal Syndrome","enrollment":320},{"nctId":"NCT06930495","phase":"","title":"The Effect of Adiposity on Muscle and Microvascular Function in HFpEF","status":"ENROLLING_BY_INVITATION","sponsor":"University of Texas Southwestern Medical Center","startDate":"2024-12-10","conditions":"Heart Failure With Preserved Ejection Fraction (HFPEF)","enrollment":95},{"nctId":"NCT07492498","phase":"NA","title":"Telemedicine-Based Integrated Care for Heart Failure Prevention in Older Patients With Atrial Fibrillation (MIRACLE-AF III)","status":"NOT_YET_RECRUITING","sponsor":"Jiangsu Taizhou People's Hospital","startDate":"2026-04-01","conditions":"Atrial Fibrillation, Heart Failure","enrollment":1268},{"nctId":"NCT06457152","phase":"NA","title":"Multi-Center Project: Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - 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