{"id":"standard-general-anesthesia","brandName":"standard general anesthesia","genericName":"standard general anesthesia","companyId":"texas-tech-university-health-sciences-center","companyName":"Texas Tech University Health Sciences Center","phase":"marketed","status":"active","modality":"Small molecule","aliases":["morphine"],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Texas Tech University Health Sciences Center is conducting multiple clinical trials to evaluate the efficacy and safety of standard general anesthesia in various surgical procedures. These include studies on hemodynamics, postoperative pain, and preoperative anxiety in children. The research spans from early phase 1 to not yet recruiting stages, with a focus on improving patient outcomes and reducing complications.","enrichmentLevel":3,"visitCount":1,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"General anesthesia typically combines intravenous agents (e.g., propofol, thiopental) that enhance GABAergic inhibition and/or block NMDA receptors, with volatile anesthetics (e.g., sevoflurane, isoflurane) that modulate ion channels and synaptic transmission. Adjunctive agents such as opioids (fentanyl), benzodiazepines, and neuromuscular blockers are often added to achieve the desired depth of unconsciousness, analgesia, and muscle paralysis for surgical procedures.","oneSentence":"Standard general anesthesia depresses the central nervous system through multiple molecular pathways to induce unconsciousness, analgesia, and muscle relaxation.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"20–30","effect":"Postoperative nausea and vomiting"},{"rate":"10–40","effect":"Hypotension"},{"rate":null,"effect":"Respiratory depression"},{"rate":"5–15","effect":"Emergence delirium"},{"rate":null,"effect":"Postoperative cognitive dysfunction"}]},"trials":[],"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia for surgical procedures"},{"name":"Sedation in intensive care settings"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}