{"id":"standard-duration-combination-nrt","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Skin irritation at patch application site"},{"rate":"5-15","effect":"Mouth irritation or hiccups (with oral forms)"},{"rate":"5-10","effect":"Nausea"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Insomnia"},{"rate":"3-5","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination approach uses nicotine in different formulations (typically a longer-acting patch combined with shorter-acting oral forms like gum or lozenge) to provide sustained baseline nicotine levels while allowing flexible dosing for breakthrough cravings. The combination addresses both the chronic nicotine dependence and acute withdrawal symptoms more effectively than monotherapy.","oneSentence":"Standard Duration Combination NRT delivers multiple forms of nicotine replacement therapy simultaneously to reduce withdrawal symptoms and support smoking cessation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:09:09.832Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Smoking cessation in adults with nicotine dependence"}]},"trialDetails":[{"nctId":"NCT05030272","phase":"NA","title":"Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2021-09-21","conditions":"Tobacco Use Disorder, Mental Illness, Recurring Major Depressive Disorder","enrollment":343},{"nctId":"NCT04199117","phase":"PHASE4","title":"Health Systems Reach Interventions Project","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2020-03-11","conditions":"Smoking, Cigarette, Smoking Cessation","enrollment":210},{"nctId":"NCT04188873","phase":"PHASE4","title":"Cessation Screening Project","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2020-12-10","conditions":"Nicotine Dependence","enrollment":529},{"nctId":"NCT03538938","phase":"PHASE4","title":"Improving Quitline Support Study","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2018-06-07","conditions":"Tobacco Use Cessation","enrollment":1316},{"nctId":"NCT04001972","phase":"NA","title":"Interactive Communication Technologies and Nicotine Replacement Therapy Sampling for Smokers","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2019-08-19","conditions":"Smoking Cessation, Tobacco Use Cessation","enrollment":664},{"nctId":"NCT03072511","phase":"PHASE4","title":"Smoking Cessation Intervention","status":"TERMINATED","sponsor":"University of Florida","startDate":"2016-12-13","conditions":"Smoking Cessation","enrollment":23}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Standard Duration Combination NRT","genericName":"Standard Duration Combination NRT","companyName":"University of Wisconsin, Madison","companyId":"university-of-wisconsin-madison","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Standard Duration Combination NRT delivers multiple forms of nicotine replacement therapy simultaneously to reduce withdrawal symptoms and support smoking cessation. Used for Smoking cessation in adults with nicotine dependence.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}