{"id":"standard-dose-synthetic-pitocin","safety":{"commonSideEffects":[{"rate":null,"effect":"Uterine hyperstimulation"},{"rate":null,"effect":"Maternal hypertension"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fetal heart rate abnormalities"},{"rate":null,"effect":"Water intoxication (with prolonged high-dose infusion)"}]},"_chembl":{"chemblId":"CHEMBL1201467","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pitocin is a synthetic form of oxytocin, a naturally occurring hormone produced by the posterior pituitary gland. It acts as an agonist at oxytocin receptors on uterine smooth muscle, triggering rhythmic contractions necessary for labor progression. It is also used to control postpartum hemorrhage by promoting sustained uterine contraction.","oneSentence":"Synthetic oxytocin that binds to oxytocin receptors to stimulate uterine contractions and promote labor induction or augmentation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:38:01.255Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Labor induction"},{"name":"Labor augmentation"},{"name":"Control of postpartum hemorrhage"},{"name":"Treatment of incomplete or inevitable abortion"}]},"trialDetails":[{"nctId":"NCT06580782","phase":"PHASE4","title":"Calcium Carbonate to Augment Labor Contractions","status":"RECRUITING","sponsor":"Weill Medical College of Cornell University","startDate":"2024-11-18","conditions":"Labor Dystocia, Labor Induction, Labor Augmentation","enrollment":60},{"nctId":"NCT03584854","phase":"PHASE4","title":"Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2019-03-01","conditions":"Postpartum Hemorrhage, Uterine Atony","enrollment":100},{"nctId":"NCT01076062","phase":"NA","title":"Elective Induction of Nulliparous Labor","status":"COMPLETED","sponsor":"Madigan Army Medical Center","startDate":"2009-10-27","conditions":"Pregnancy","enrollment":162},{"nctId":"NCT04143685","phase":"NA","title":"Labor Induction With Misoprostol Versus Oxytocin in Women With Premature Rupture of Membranes","status":"UNKNOWN","sponsor":"sammour.rami","startDate":"2019-12-01","conditions":"Prelabor Rupture of Membranes, Premature Rupture of Membrane","enrollment":200},{"nctId":"NCT03509168","phase":"PHASE2, PHASE3","title":"The Efficacy and Safety of Preoperative Misoprostol in Blood-loss Reduction During Myomectomy.","status":"UNKNOWN","sponsor":"Makerere University","startDate":"2018-01-10","conditions":"Uterine Fibroid","enrollment":46}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Standard Dose Synthetic Pitocin","genericName":"Standard Dose Synthetic Pitocin","companyName":"Weill Medical College of Cornell University","companyId":"weill-medical-college-of-cornell-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Synthetic oxytocin that binds to oxytocin receptors to stimulate uterine contractions and promote labor induction or augmentation. Used for Labor induction, Labor augmentation, Control of postpartum hemorrhage.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}