{"id":"standard-dose-colistin","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Nephrotoxicity (acute kidney injury)"},{"rate":"5-20","effect":"Neurotoxicity (paresthesias, dizziness, vertigo)"},{"rate":"1-5","effect":"Neuromuscular blockade"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":{"chemblId":"CHEMBL6067481","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Colistin is a polymyxin antibiotic that acts as a cationic detergent, inserting into the outer and inner membranes of gram-negative bacteria. This disrupts membrane integrity and leads to leakage of cellular contents and bacterial cell death. It is primarily used against multidrug-resistant gram-negative organisms when other antibiotics have failed.","oneSentence":"Colistin disrupts bacterial cell membranes by binding to lipopolysaccharides and phospholipids, causing cell lysis and death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:09:09.004Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Multidrug-resistant gram-negative bacterial infections (e.g., Pseudomonas aeruginosa, Acinetobacter baumannii)"},{"name":"Hospital-acquired pneumonia caused by susceptible gram-negative organisms"},{"name":"Urinary tract infections caused by resistant gram-negative bacteria"}]},"trialDetails":[{"nctId":"NCT05865743","phase":"PHASE3","title":"Perioperative SDD to Prevent Infectious Complications After Esophagectomy","status":"RECRUITING","sponsor":"Radboud University Medical Center","startDate":"2024-10-21","conditions":"Esophageal Cancer","enrollment":854},{"nctId":"NCT06419296","phase":"","title":"Mortality of MBL-producing Enterobacteriaceae Bacteremias with the Combined Use of Ceftazidime-avibactam and Aztreonam Vs. 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Jaap Bonjer, PhD","startDate":"2013-01","conditions":"Colorectal Cancer","enrollment":485},{"nctId":"NCT02208154","phase":"PHASE3","title":"Ecological Effects of Decolonisation Strategies in Intensive Care","status":"COMPLETED","sponsor":"MJM Bonten","startDate":"2013-12-01","conditions":"ICU-ecology (Multidrug Resistant Bacteria), ICU-acquired Bacteraemia","enrollment":8665},{"nctId":"NCT01845246","phase":"NA","title":"Multicentric Study About the Usefulness of Monitoring Plasma Levels of Colistin and Sodium Colistimethate in Patients With Infections Due to Multi-drug Resistant Gram Negative Bacilli, Treated With Colistin","status":"COMPLETED","sponsor":"Parc de Salut Mar","startDate":"2012-01","conditions":"Multidrug Resistant Gram Negative Bacterial Infections","enrollment":101},{"nctId":"NCT02162966","phase":"PHASE4","title":"Safety and Efficacy Study of High Dose Colistin","status":"UNKNOWN","sponsor":"King Saud Medical City","startDate":"2014-05","conditions":"Infectious Diseases","enrollment":330}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Colistin"],"phase":"marketed","status":"active","brandName":"Standard Dose Colistin","genericName":"Standard Dose Colistin","companyName":"King Saud Medical City","companyId":"king-saud-medical-city","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Colistin disrupts bacterial cell membranes by binding to lipopolysaccharides and phospholipids, causing cell lysis and death. Used for Multidrug-resistant gram-negative bacterial infections (e.g., Pseudomonas aeruginosa, Acinetobacter baumannii), Hospital-acquired pneumonia caused by susceptible gram-negative organisms, Urinary tract infections caused by resistant gram-negative bacteria.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}