{"id":"standard-dose-ara-c","safety":{"commonSideEffects":[{"rate":"80-90","effect":"Myelosuppression (neutropenia, thrombocytopenia, anemia)"},{"rate":"60-70","effect":"Nausea and vomiting"},{"rate":"40-60","effect":"Mucositis"},{"rate":"10-20","effect":"Hepatotoxicity"},{"rate":"5-15","effect":"Neurotoxicity (at high doses)"},{"rate":"30-50","effect":"Infection"},{"rate":"20-30","effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ARA-C is a nucleoside analog that mimics cytidine and is phosphorylated intracellularly to its active triphosphate form. This active metabolite competes with natural deoxycytidine triphosphate for incorporation into DNA during replication. Once incorporated, it causes chain termination and prevents further DNA synthesis, triggering apoptosis in rapidly dividing cells, particularly hematopoietic malignancies.","oneSentence":"ARA-C (cytarabine) is a cytidine analog that inhibits DNA synthesis by being incorporated into DNA and blocking chain elongation, leading to cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:09:06.851Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute myeloid leukemia (AML)"},{"name":"Acute lymphoblastic leukemia (ALL)"},{"name":"Chronic myeloid leukemia (CML) in blast crisis"},{"name":"Lymphoma"}]},"trialDetails":[{"nctId":"NCT06744504","phase":"PHASE3","title":"Standard-dose vs Intermediate-dose Cytarabine Induction in the Treatment of Acute Myeloid Leukemia With RUNX1-RUNX1T1","status":"RECRUITING","sponsor":"Institute of Hematology & Blood Diseases Hospital, China","startDate":"2025-01-10","conditions":"AML, RUNX1-RUNX1T1 Fusion Protein 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