{"id":"standard-adjuvant-chemotherapy-plus-moxifloxacin","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-15%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1200735","moleculeType":"Small molecule","molecularWeight":"437.90"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This action results in the inhibition of bacterial DNA replication and transcription, ultimately leading to bacterial cell death. Moxifloxacin is a fluoroquinolone antibiotic, which is a class of drugs that target bacterial DNA enzymes. By inhibiting these enzymes, moxifloxacin is able to effectively treat a wide range of bacterial infections.","oneSentence":"Moxifloxacin is a broad-spectrum antibiotic that inhibits bacterial DNA replication by binding to the bacterial DNA gyrase and topoisomerase IV.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:36:04.218Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Community-acquired pneumonia"},{"name":"Skin and skin structure infections"},{"name":"Complicated urinary tract infections"},{"name":"Acute bacterial sinusitis"}]},"trialDetails":[{"nctId":"NCT05114720","phase":"PHASE3","title":"Moxifloxacin in Adjuvant Treatment of Patients With Operable Breast Cancer","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2021-11-11","conditions":"Breast Cancer","enrollment":559}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Standard adjuvant chemotherapy (Docetaxel combined with cyclophosphamide or doxorubicin combined with cyclophosphamide followed by docetaxel) plus antibiotic (moxifloxacin)"],"phase":"phase_3","status":"active","brandName":"standard adjuvant chemotherapy plus moxifloxacin","genericName":"standard adjuvant chemotherapy plus moxifloxacin","companyName":"Sun Yat-sen University","companyId":"sun-yat-sen-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Moxifloxacin is a broad-spectrum antibiotic that inhibits bacterial DNA replication by binding to the bacterial DNA gyrase and topoisomerase IV. Used for Community-acquired pneumonia, Skin and skin structure infections, Complicated urinary tract infections.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}