{"id":"srp-aloe","safety":{"commonSideEffects":[{"rate":null,"effect":"Gum irritation"},{"rate":null,"effect":"Allergic reaction to Aloe"},{"rate":null,"effect":"Tooth sensitivity"}]},"_chembl":{"chemblId":"CHEMBL40275","moleculeType":"Small molecule","molecularWeight":"270.24"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"SRP is a mechanical debridement procedure that removes calculus and biofilm from tooth surfaces and root surfaces below the gum line. Aloe vera is added as an adjunctive topical agent to enhance healing, reduce bacterial load, and modulate the inflammatory response in periodontal tissues. The combination aims to improve clinical outcomes in periodontal disease management.","oneSentence":"SRP (Scaling and Root Planing) combined with Aloe vera promotes periodontal healing and reduces inflammation in gum disease through mechanical plaque removal and the antimicrobial and anti-inflammatory properties of Aloe.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:37:59.247Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic periodontitis"},{"name":"Gingivitis"}]},"trialDetails":[{"nctId":"NCT06041178","phase":"PHASE4","title":"Flurbiprofen Versus Aloe Vera Gel in the Treatment of Chronic Periodontitis in Smoking Patients.","status":"COMPLETED","sponsor":"Beirut Arab University","startDate":"2022-09-30","conditions":"Periodontitis Chronic Generalized Severe","enrollment":60},{"nctId":"NCT04615585","phase":"NA","title":"Evaluation of Local Delivery of Aloe Vera Gel as an Adjunct to Non-surgical Treatment in Patients With Chronic Periodontitis","status":"COMPLETED","sponsor":"Nourhan M.Aly","startDate":"2018-07-15","conditions":"Chronic Periodontitis","enrollment":30},{"nctId":"NCT03204097","phase":"PHASE2, PHASE3","title":"Local Host Modulating Agents Alendronate & Aloe Vera for Treatment of Furcation Defects in Chronic Periodontitis","status":"COMPLETED","sponsor":"Government Dental College and Research Institute, Bangalore","startDate":"2016-03","conditions":"Chronic Periodontitis","enrollment":90},{"nctId":"NCT03083535","phase":"NA","title":"Efficacy of AloeVera Gel Gum Massaging and Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients","status":"UNKNOWN","sponsor":"Government College of Dentistry, Indore","startDate":"2016-01","conditions":"CHRONIC PERIODONTITIS","enrollment":120},{"nctId":"NCT02462993","phase":"PHASE2, PHASE3","title":"Local Drug Delivery of Aloe Vera Gel in Chronic Periodontitis","status":"COMPLETED","sponsor":"Dr. D. Y. Patil Dental College & Hospital","startDate":"2014-02","conditions":"Periodontitis","enrollment":12},{"nctId":"NCT02437747","phase":"PHASE4","title":"Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus","status":"COMPLETED","sponsor":"Dr. D. Y. Patil Dental College & Hospital","startDate":"2014-06","conditions":"Diabetes Mellitus, Chronic Periodontitis","enrollment":15},{"nctId":"NCT02386020","phase":"PHASE2, PHASE3","title":"Aloe Vera in Chronic Periodontitis With Type 2 Diabetes Mellitus","status":"COMPLETED","sponsor":"Government Dental College and Research Institute, Bangalore","startDate":"2014-06","conditions":"Chronic Periodontitis","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":14,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Korphad Ghar"],"phase":"marketed","status":"active","brandName":"SRP + Aloe","genericName":"SRP + Aloe","companyName":"Dr. D. Y. Patil Dental College & Hospital","companyId":"dr-d-y-patil-dental-college-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aloe Vera is a small molecule used in a clinical trial for the treatment of Chronic Periodontitis, specifically in the form of a gel. The trial, NCT03204097, also investigated the use of Alendronate, a small molecule, in combination with Aloe Vera for the treatment of furcation defects in Chronic Periodontitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}