{"id":"sr-89","safety":{"commonSideEffects":[{"rate":null,"effect":"Bone marrow suppression (thrombocytopenia, leukopenia)"},{"rate":null,"effect":"Transient increase in bone pain (flare reaction)"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":{"setId":"c89bcf16-399d-48e0-a4e3-849261aaa310","title":"STRONTIUM CHLORIDE SR-89 (STRONTIUM CHLORIDE SR-89) INJECTION [Q BIOMED INC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sr-89 is taken up by osteoblasts in bone lesions due to its chemical similarity to calcium. Once localized to sites of increased bone turnover (such as metastatic lesions), it emits beta particles that deliver high local radiation dose to the tumor and surrounding bone tissue, causing pain relief. The mechanism provides palliative benefit by destroying metastatic bone lesions and reducing osteoclastic activity.","oneSentence":"Strontium-89 is a beta-emitting radioisotope that localizes to areas of increased bone metabolism and delivers targeted radiation to relieve bone pain in patients with skeletal metastases.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:09:01.865Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bone pain palliation in patients with skeletal metastases from cancer (prostate cancer, breast cancer, and other malignancies with bone involvement)"}]},"trialDetails":[{"nctId":"NCT06748404","phase":"PHASE2","title":"TriCalm Hydrogel® in the Treatment of Immunotherapy-Related Pruritus","status":"RECRUITING","sponsor":"University of California, San Diego","startDate":"2025-01-31","conditions":"Immunotherapy-related Pruritus","enrollment":28},{"nctId":"NCT01595815","phase":"NA","title":"Successful Pregnancy and Delivery After AOA","status":"COMPLETED","sponsor":"Maria Fertility Hospital","startDate":"2007-05","conditions":"Infertility","enrollment":100},{"nctId":"NCT00365105","phase":"PHASE3","title":"Zoledronate, Vitamin D, and Calcium With or Without Strontium 89 or Samarium 153 in Preventing or Delaying Bone Problems in Patients With Bone Metastases From Prostate Cancer, Lung Cancer, or Breast Cancer","status":"COMPLETED","sponsor":"Radiation Therapy Oncology Group","startDate":"2006-07-11","conditions":"Breast Cancer, Lung Cancer, Metastatic Cancer","enrollment":261},{"nctId":"NCT05466812","phase":"PHASE4","title":"Efficacy of Sr-89 for Differentiated Thyroid Cancer With Bone Metastases","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2022-07-13","conditions":"Thyroid Neoplasm Follicular, Bone Metastases","enrollment":20},{"nctId":"NCT04356911","phase":"NA","title":"The Strontium Chloride Associated With Photobiomodulation in the Control of Post-bleaching Sensitivity","status":"COMPLETED","sponsor":"Universidade Federal do Para","startDate":"2018-08-01","conditions":"Dentin Sensitivity","enrollment":50},{"nctId":"NCT00080782","phase":"PHASE2","title":"Doxorubicin and Strontium-89 With or Without Celecoxib in Treating Patients With Progressive Androgen-Independent Prostate Cancer and Bone Metastases","status":"TERMINATED","sponsor":"M.D. Anderson Cancer Center","startDate":"2002-02","conditions":"Metastatic Cancer, Prostate Cancer","enrollment":14},{"nctId":"NCT02418416","phase":"NA","title":"Novel Approach With Double Agent Artificial Oocyte Activation for Repeated Fertilization Failure Due to Combined Sperm and Oocyte Factor","status":"COMPLETED","sponsor":"Ibn Sina Hospital","startDate":"2015-05-06","conditions":"Infertility","enrollment":400},{"nctId":"NCT02424214","phase":"NA","title":"Artificial Oocyte Activation Comparing Tow Different Agents","status":"COMPLETED","sponsor":"Ibn Sina Hospital","startDate":"2015-04","conditions":"Oocyte Fertilization","enrollment":450},{"nctId":"NCT00081159","phase":"PHASE2","title":"Hormone Ablation Therapy, Doxorubicin, and Zoledronate With or Without Strontium 89 in Treating Patients With Androgen-Dependent Prostate Cancer and Bone Metastases","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2004-07","conditions":"Metastatic Cancer, Prostate Cancer","enrollment":80},{"nctId":"NCT00024167","phase":"PHASE3","title":"Chemotherapy With or Without Strontium-89 in Treating Patients With Prostate Cancer","status":"TERMINATED","sponsor":"M.D. Anderson Cancer Center","startDate":"2002-04","conditions":"Prostate Cancer","enrollment":265},{"nctId":"NCT02128633","phase":"PHASE2, PHASE3","title":"Effectiveness of a Homecare Dentin Hypersensitivity Gel","status":"COMPLETED","sponsor":"Universidade Federal de Santa Maria","startDate":"2009-11","conditions":"Dentin Sensitivity","enrollment":126},{"nctId":"NCT00554918","phase":"PHASE2","title":"Docetaxel and Prednisolone With or Without Zoledronic Acid and/or Strontium Chloride Sr 89 in Treating Patients With Prostate Cancer Metastatic to Bone That Has Not Responded to Hormone Therapy","status":"COMPLETED","sponsor":"University Hospital Birmingham","startDate":"2005-02","conditions":"Metastatic Cancer, Prostate Cancer","enrollment":300},{"nctId":"NCT00002503","phase":"PHASE3","title":"Strontium Compared With Radiation Therapy in Treating Patients With Hormone-Refractory Prostate Cancer With Painful Bone Metastases","status":"COMPLETED","sponsor":"European Organisation for Research and Treatment of Cancer - 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Used for Bone pain palliation in patients with skeletal metastases from cancer (prostate cancer, breast cancer, and other malignancies with bone involvement).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}