{"id":"split-dose-pico-salax","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal pain or cramping"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Electrolyte disturbances"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pico-Salax combines sodium picosulfate (a stimulant laxative prodrug) with magnesium citrate (an osmotic agent). Sodium picosulfate is metabolized by colonic bacteria to bis-(p-hydroxyphenyl)-pyridyl-methane, which stimulates colonic contractions. The magnesium citrate creates an osmotic gradient that increases stool water content, promoting rapid bowel cleansing. The split-dose regimen administers the preparation in two divided doses to improve tolerability and efficacy.","oneSentence":"Pico-Salax is an osmotic laxative that draws water into the colon to promote bowel evacuation for colonoscopy preparation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:08:57.882Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel cleansing prior to colonoscopy"}]},"trialDetails":[{"nctId":"NCT00885274","phase":"PHASE4","title":"A Randomized Controlled Trial Comparing Two Timing Regimens of Pico-salax for Colon Cleansing Prior to Colonoscopy","status":"COMPLETED","sponsor":"Queen's University","startDate":"2008-11","conditions":"Colonoscopy","enrollment":250},{"nctId":"NCT01627171","phase":"PHASE4","title":"Colonoscopy Preparation Optimization for INpatients- COIN Study","status":"UNKNOWN","sponsor":"St. Joseph's Healthcare Hamilton","startDate":"2012-09","conditions":"Endoscopy, Bowel Preparation Solutions","enrollment":126},{"nctId":"NCT01415687","phase":"PHASE3","title":"Split Dose Pico-Salax + Bisacodyl vs. PEG Split Dose","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2011-05","conditions":"Bowel Preparation for Colonoscopy","enrollment":171}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Split Dose Pico-Salax","genericName":"Split Dose Pico-Salax","companyName":"Queen's University","companyId":"queen-s-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pico-Salax is an osmotic laxative that draws water into the colon to promote bowel evacuation for colonoscopy preparation. Used for Bowel cleansing prior to colonoscopy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}