{"id":"spironolactone-furosemide","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Gynecomastia (spironolactone)"},{"rate":null,"effect":"Ototoxicity (furosemide)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Spironolactone is a potassium-sparing diuretic that antagonizes aldosterone in the collecting duct, reducing sodium reabsorption and potassium excretion. Furosemide is a loop diuretic that inhibits the Na-K-2Cl cotransporter, producing potent diuresis but causing potassium loss. Combined, they provide synergistic diuretic effect while the potassium-sparing action of spironolactone counterbalances furosemide-induced hypokalemia.","oneSentence":"Spironolactone blocks aldosterone to retain potassium while furosemide inhibits sodium reabsorption to promote diuresis, together providing balanced fluid and electrolyte management.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:08:56.873Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Edema and fluid overload in heart failure"},{"name":"Edema in cirrhosis and renal disease"},{"name":"Hypertension with hypokalemia risk"}]},"trialDetails":[{"nctId":"NCT07223502","phase":"PHASE3","title":"A Study Comparing the Clinical Benefit of Finerenone Versus a Fixed Dose Combination (FDC) of Extended-Release Torsemide and Spironolactone in Patients With Hypertension and Chronic Kidney Disease","status":"RECRUITING","sponsor":"Sarfez Pharmaceuticals, 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Used for Edema and fluid overload in heart failure, Edema in cirrhosis and renal disease, Hypertension with hypokalemia risk.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}