{"id":"spironolacton-hexalacton-r","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Gynecomastia"},{"rate":null,"effect":"Menstrual irregularities"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Spironolactone competitively inhibits aldosterone at mineralocorticoid receptors, preventing sodium and water reabsorption while promoting potassium retention. This dual action reduces blood volume and blood pressure while preserving serum potassium levels. It is commonly used in heart failure, hypertension, and hyperaldosteronism management.","oneSentence":"Spironolactone is a potassium-sparing diuretic and aldosterone antagonist that blocks aldosterone receptors in the collecting duct of the kidney to reduce sodium reabsorption and increase potassium retention.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:09:03.515Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Heart failure with reduced ejection fraction"},{"name":"Hypertension"},{"name":"Primary hyperaldosteronism"},{"name":"Edema associated with cirrhosis or nephrotic syndrome"}]},"trialDetails":[{"nctId":"NCT00843388","phase":"PHASE4","title":"A Crossover Study With Hexalacton in Patients With Type 1 Diabetes and Microalbuminuria","status":"UNKNOWN","sponsor":"Steno Diabetes Center Copenhagen","startDate":"2009-03","conditions":"Diabetes Mellitus, Nephropathy, Blood Pressure","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Spironolacton (hexalacton(R))","genericName":"Spironolacton (hexalacton(R))","companyName":"Steno Diabetes Center Copenhagen","companyId":"steno-diabetes-center-copenhagen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Spironolactone is a potassium-sparing diuretic and aldosterone antagonist that blocks aldosterone receptors in the collecting duct of the kidney to reduce sodium reabsorption and increase potassium retention. Used for Heart failure with reduced ejection fraction, Hypertension, Primary hyperaldosteronism.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}