{"id":"spiramycin-iii","rwe":[],"tags":[{"label":"Spiramycin III","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:27:45.215561","allNames":"spiramycin 3","offLabel":[],"synonyms":["Spiramycin C","Spiramycin III","Foromacidin C","Foromacidine C","Spiramycin 3"],"timeline":[],"brandName":"Spiramycin 3","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Spiramycin III","explanation":"Imagine your body's cells are like factories that produce proteins to keep you healthy. Bacteria are like tiny factories that produce proteins to make them sick. Spiramycin III stops these bacterial factories from working by blocking the production of essential proteins, which ultimately kills the bacteria.","oneSentence":"Spiramycin III works by inhibiting protein synthesis in bacteria, preventing them from producing essential proteins and ultimately leading to cell death.","technicalDetail":"Spiramycin III exerts its antibacterial effects by binding to the 50S subunit of the bacterial ribosome, inhibiting peptide bond formation and thus preventing protein synthesis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2473","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Spiramycin III","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T07:26:01.058577","biosimilars":[],"competitors":[],"genericName":"spiramycin iii","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(7)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"0NHE9TRJ93","CHEBI":"CHEBI:82005","UMLSCUI":"C0255923","PUBCHEM_CID":"6440708","MESH_SUPPLEMENTAL_RECORD_UI":"C087816"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[{"date":"2023 Apr 14","pmid":"37122599","title":"Anti-inflammatory effect and antihepatoma mechanism of carrimycin.","journal":"World journal of gastroenterology"},{"date":"2017 May 28","pmid":"28278108","title":"Influence of Al(3+) on the titer of spiramycin and effective components in fermentor.","journal":"Preparative biochemistry & biotechnology"},{"date":"2014 Feb","pmid":"24356910","title":"Identification of 4″-isovaleryl-spiramycin III produced by Bacillus sp. fmbJ.","journal":"Archives of microbiology"},{"date":"1979 Jun","pmid":"468735","title":"Bioconversion and biosynthesis of 16-membered macrolide antibiotics. XIII. Regulation of spiramycin I 3-hydroxyl acylase formation by glucose, butyrate, and cerulenin.","journal":"The Journal of antibiotics"},{"date":"1974 Nov","pmid":"15825314","title":"Effect of leucomycins and analogues on binding [14C ]erythromycin to Escherichia coli ribosomes.","journal":"Antimicrobial agents and chemotherapy"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Spiramycin 3 is a small molecule that inhibits the bacterial 70S ribosome. It belongs to the class of inhibitors and is a bacterial 70S ribosome inhibitor.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}