{"id":"spiramycin-ii","rwe":[],"tags":[{"label":"Spiramycin II","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":["NCT00004317"],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:28:47.505234","allNames":"spiramycin 2","offLabel":[],"synonyms":["Spiramycin II","acetylspiramycin","Foromacidin B","Foromacidine B","Spiramycin 2"],"timeline":[],"brandName":"Spiramycin 2","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Spiramycin II","explanation":"Think of it like a factory where bacteria make proteins. Spiramycin II blocks the factory's machinery, stopping the bacteria from making the proteins they need to grow and multiply. This ultimately leads to the death of the bacteria, helping to clear up infections.","oneSentence":"Spiramycin II works by inhibiting protein synthesis in bacteria, preventing them from producing essential proteins needed for growth and survival.","technicalDetail":"Spiramycin II exerts its antibacterial effects by binding to the 50S subunit of the bacterial ribosome, inhibiting peptide bond formation and thus preventing protein synthesis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2472","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Spiramycin II","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:19:39.240659","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"spiramycin ii","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(3)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT00004317","phase":"Phase 4","title":"Phase IV Randomized Study of Pyrimethamine, Sulfadiazine, and Leucovorin Calcium for Congenital Toxoplasmosis","status":"RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","isPivotal":false,"enrollment":600,"indication":"Toxoplasmosis","completionDate":"2030-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"05298J5WMU","CHEBI":"CHEBI:31168","UMLSCUI":"C0050540","ChEMBL_ID":"CHEMBL453514","KEGG_DRUG":"D02420","PUBCHEM_CID":"49787020","SNOMEDCT_US":"698261002","MESH_SUPPLEMENTAL_RECORD_UI":"C033163"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[{"date":"2017 May 28","pmid":"28278108","title":"Influence of Al(3+) on the titer of spiramycin and effective components in fermentor.","journal":"Preparative biochemistry & biotechnology"},{"date":"2011 Jan","pmid":"20490499","title":"Construction of 4\"-isovalerylspiramycin-I-producing strain by in-frame partial deletion of 3-O-acyltransferase gene in Streptomyces spiramyceticus WSJ-1, the bitespiramycin producer.","journal":"Current microbiology"},{"date":"2008 Dec","pmid":"19306580","title":"[Acylation specificity of midecamycin 3-O-acyltransferase within Streptomyces spiramyceticus F21].","journal":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Spiramycin is a small molecule that inhibits the bacterial 70S ribosome. It is used to treat Toxoplasmosis, as indicated by clinical trials on ClinicalTrials.gov.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}