{"id":"spiramycin-i","rwe":[{"pmid":"39654915","year":"2024","title":"Synthesis, anticancer and antibacterial evaluation of novel spiramycin-acylated derivatives.","finding":"","journal":"RSC advances","studyType":"Clinical Study"},{"pmid":"30221219","year":"2018","title":"Stimulatory Effects of Methyl-β-cyclodextrin on Spiramycin Production and Physical-Chemical Characterization of Nonhost@Guest Complexes.","finding":"","journal":"ACS omega","studyType":"Clinical Study"},{"pmid":"28278108","year":"2017","title":"Influence of Al(3+) on the titer of spiramycin and effective components in fermentor.","finding":"","journal":"Preparative biochemistry & biotechnology","studyType":"Clinical Study"},{"pmid":"28095730","year":"2017","title":"Anaerobic biodegradation of spiramycin I and characterization of its new metabolites.","finding":"","journal":"Bioscience, biotechnology, and biochemistry","studyType":"Clinical Study"},{"pmid":"24345568","year":"2014","title":"Hydroxylation and hydrolysis: two main metabolic ways of spiramycin I in anaerobic digestion.","finding":"","journal":"Bioresource technology","studyType":"Clinical Study"}],"tags":[{"label":"Spiramycin I","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:28:36.253625","allNames":"leucomycin v","offLabel":[],"synonyms":["Foromacidine A","Spiramycin I","Leucomycin V"],"timeline":[],"brandName":"Leucomycin V","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Spiramycin I","explanation":"Imagine your body's cells are like factories that make proteins. Bacteria are like tiny factories that also make proteins, but they can cause harm. Spiramycin I stops these bacterial factories from making proteins by binding to a specific part of the factory, called the 50S ribosomal subunit.","oneSentence":"Spiramycin I works by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit.","technicalDetail":"Spiramycin I binds to the 50S ribosomal subunit, preventing the translocation of peptidyl-tRNA and thereby inhibiting peptide bond formation, which is essential for bacterial protein synthesis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2471","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=Spiramycin%20I","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Spiramycin I","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:19:34.481116","biosimilars":[],"competitors":[],"genericName":"spiramycin i","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(24)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT01189448","phase":"PHASE3","title":"Prevention of Congenital Toxoplasmosis With Pyrimethamine + Sulfadiazine Versus Spiramycine During Pregnancy","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2010-11","conditions":["Congenital Toxoplasmosis"],"enrollment":149,"completionDate":"2016-04"},{"nctId":"NCT00004317","phase":"PHASE4","title":"Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis","status":"RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2000-07","conditions":["Toxoplasmosis"],"enrollment":600,"completionDate":"2030-12"},{"nctId":"NCT00002062","phase":"NA","title":"Open-Label \"Compassionate\" Use Study of Spiramycin for the Treatment of Diarrhea Due to Chronic Cryptosporidiosis in Immunocompromised Patients","status":"COMPLETED","sponsor":"Rhone-Poulenc Rorer","startDate":"","conditions":["Cryptosporidiosis","HIV Infections"],"enrollment":0,"completionDate":""},{"nctId":"NCT00000980","phase":"PHASE1","title":"A Study of Spiramycin in the Treatment of Patients With AIDS-Related Diarrhea","status":"COMPLETED","sponsor":"Rhone-Poulenc Rorer","startDate":"","conditions":["Cryptosporidiosis","HIV Infections"],"enrollment":25,"completionDate":""}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"002766","UNII":"033ECH6IFG","CHEBI":"CHEBI:85260","RXNORM":"9991","UMLSCUI":"C0037962","ChEMBL_ID":"CHEMBL453514","DRUGBANK_ID":"DB06145","PDB_CHEM_ID":" SPR","PUBCHEM_CID":"6440717","SNOMEDCT_US":"302007","SECONDARY_CAS_RN":"22875-15-6"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":24,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[{"date":"2024 Dec 3","pmid":"39654915","title":"Synthesis, anticancer and antibacterial evaluation of novel spiramycin-acylated derivatives.","journal":"RSC advances"},{"date":"2018 Mar 31","pmid":"30221219","title":"Stimulatory Effects of Methyl-β-cyclodextrin on Spiramycin Production and Physical-Chemical Characterization of Nonhost@Guest Complexes.","journal":"ACS omega"},{"date":"2017 May 28","pmid":"28278108","title":"Influence of Al(3+) on the titer of spiramycin and effective components in fermentor.","journal":"Preparative biochemistry & biotechnology"},{"date":"2017 May","pmid":"28095730","title":"Anaerobic biodegradation of spiramycin I and characterization of its new metabolites.","journal":"Bioscience, biotechnology, and biochemistry"},{"date":"2014 Feb","pmid":"24345568","title":"Hydroxylation and hydrolysis: two main metabolic ways of spiramycin I in anaerobic digestion.","journal":"Bioresource technology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Leucomycin V is a small molecule with synonyms including Acetylspiromycin, Espiramicina, IL 5902, IL-5902, NSC-55926, and NSC-64393.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}